trichocolein | 178437-32-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: trichocolein
• 英文别名: Methyl 3-methoxy-4-(3-methylbut-2-enoxy)benzoate
• CAS: 178437-32-6
• 化学式: C₁₄H₁₈O₄
• 分子量: 250.295
• InChiKey: KEUKLFKJOAOBAS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  18
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  44.8
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  trichocolein 在 sodium hydroxide 作用下， 反应 1.0h， 生成 3-methoxy-4-[(3-methylbut-2-enyl)oxy]benzoic acid
  参考文献：
  名称：

  In vitro inhibitory activity of boropinic acid against Helicobacter pylori

  摘要：

  In this study, we assessed in vitro minimum inhibitory concentration (MIC) values of some natural geranyloxycoumarins, geranyloxy- and isopentenyloxy acids against growth of Helicobacter pylori. Boropinic acid, active principle isolated from Boronia pinnata (Fam. Rutaceae), was seen to be the most effective compound with a MIC value of 1.62 mu g/mL. (c) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2006.08.043
• 作为产物：
  描述：

  香草酸 在 硫酸 、 potassium carbonate 作用下， 以 丙酮 为溶剂， 反应 14.0h， 生成 trichocolein
  参考文献：
  名称：

  In vitro inhibitory activity of boropinic acid against Helicobacter pylori

  摘要：

  In this study, we assessed in vitro minimum inhibitory concentration (MIC) values of some natural geranyloxycoumarins, geranyloxy- and isopentenyloxy acids against growth of Helicobacter pylori. Boropinic acid, active principle isolated from Boronia pinnata (Fam. Rutaceae), was seen to be the most effective compound with a MIC value of 1.62 mu g/mL. (c) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2006.08.043

文献信息

• ARYLOYL(OXY OR AMINO)PENTAFLUOROSULFANYLBENZENE COMPOUND, PHARMACEUTICALLY ACCEPTABLE SALT THEREOF, AND PRODRUGS THEREOF
  申请人：UBE INDUSTRIES, LTD.

  公开号：US20160244407A1

  公开（公告）日：2016-08-25

  An aryloyl(oxy or amino)pentafluorosulfanylbenzene compound having pharmacological action. The aryloyl(oxy or amino)pentafluorosulfanylbenzene compound is represented by general formula (A-I), a pharmaceutically acceptable salt thereof, and a prodrug thereof, wherein all of parameters represent the same meanings as defined in the specification.

  一种具有药理作用的芳基酰氧或氨基五氟磺基苯化合物。该芳基酰氧或氨基五氟磺基苯化合物由通用式(A-I)表示，其药用可接受的盐和前药，其中所有参数的含义与规范中定义的相同。
• Isoprenyl Phenyl Ethers from Liverworts of the Genus <i>Trichocolea</i>:  Cytotoxic Activity, Structural Corrections, and Synthesis
  作者：Nigel B. Perry、Lysa M. Foster、Stephen D. Lorimer、Barnaby C. H. May、Rex T. Weavers、Masao Toyota、Eri Nakaishi、Yoshinori Asakawa

  DOI：10.1021/np9603378

  日期：1996.1.1

  The main cytotoxic component in New Zealand collections of the liverwort Trichocolea mollissima was identified as methyl 4-[(5-oxogeranyl)oxy]-3-methoxybenzoate, a structure that has not been reported previously. Two double-bond isomers of this geranyl ether were present at lower levels. Reinvestigation of the benzoates from Japanese collections of Trichocolea tomentella led to the identification of four geranyl ethers (including two of the three compounds identified from T. mollissima), which had previously been assigned incorrect geranyl ester structures. One compound, previously reported as a 3,3-dimethylallyl ester, could not be reisolated from T. tomentella, but was found in a New Zealand collection of Trichocolea lanata. It was shown to be a 3,3-dimethylallyl ether by synthesis from methyl vanillate. Several of these compounds were active in cytotoxic and antifungal assays.
• US9682931B2
  申请人：——

  公开号：US9682931B2

  公开（公告）日：2017-06-20
• In vitro inhibitory activity of boropinic acid against Helicobacter pylori
  作者：Francesco Epifano、Luigi Menghini、Rita Pagiotti、Paola Angelini、Salvatore Genovese、Massimo Curini

  DOI：10.1016/j.bmcl.2006.08.043

  日期：2006.11

  In this study, we assessed in vitro minimum inhibitory concentration (MIC) values of some natural geranyloxycoumarins, geranyloxy- and isopentenyloxy acids against growth of Helicobacter pylori. Boropinic acid, active principle isolated from Boronia pinnata (Fam. Rutaceae), was seen to be the most effective compound with a MIC value of 1.62 mu g/mL. (c) 2006 Elsevier Ltd. All rights reserved.