5,6-dimethoxy-2-methylisoindoline | 114041-11-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 异吲哚及其衍生物
• 英文名称: 5,6-dimethoxy-2-methylisoindoline
• 英文别名: 5,6-dimethoxy-N-methylisoindoline；2,3-Dihydro-5,6-dimethoxy-2-methyl-1H-isoindole；5,6-dimethoxy-2-methyl-1,3-dihydroisoindole
• CAS: 114041-11-1
• 化学式: C₁₁H₁₅NO₂
• 分子量: 193.246
• InChiKey: HLPXYDUICWZOOO-UHFFFAOYSA-N

物化性质

• 沸点：
  267.6±40.0 °C(Predicted)
• 密度：
  1.088±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  21.7
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  5,6-dimethoxy-2-methylisoindoline 在 氢溴酸 作用下， 反应 3.0h， 生成 2-methylisoindoline-5,6-diol hydrobromide salt
  参考文献：
  名称：

  Cephem Compounds with Latent Reactive Groups

  摘要：

  具有在头孢菌素或青霉烷素环中3位处具有苯乙烯亚甲基基团的头孢菌素和青霉烷素化合物，其中正电离子离去基团与离去基团中含有邻二醇或连接到未取代或取代过的邻苯二酚。离去基团可以是正电离子离去基团。头孢菌素包括头孢菌素、头孢菌烷、卡巴头孢菌素和氧头孢菌素。青霉烷素包括青霉烷素、碳青霉烷素和氧青霉烷素。首选头孢菌素是头孢菌素。首选青霉烷素是碳青霉烷素。化合物对革兰氏阴性细菌和/或革兰氏阳性细菌表现出抗生素活性。化合物对表现出多重耐药性的细菌表现出抗生素活性。本发明的化合物表现出抗生素活性，对产生扩展谱β-内酰胺酶（ESBL）、产生AmpCβ-内酰胺酶或产生碳青霉烷酶的细菌菌株表现出抗生素活性。包括一种或多种头孢菌素或青霉烷素的制药组合物或使用这些化合物和组合物治疗细菌感染的方法。

  公开号：

  US20190100534A1
• 作为产物：
  描述：

  N-benzyl-5,6-dimethoxy-N-methylisoindolinium iodide 在 palladium-carbon sodium hydroxide 作用下， 以 甲醇 、 氢气 为溶剂， 生成 5,6-dimethoxy-2-methylisoindoline
  参考文献：
  名称：

  Process for the production of isoindoline derivatives, novel

  摘要：

  一种生产以下化合物的方法：##STR1## 其中R.sup.1是氢原子、较低的烷基基团或芳基烷基基团，R.sup.2是氢原子或羟基保护基团，或其盐，包括从以下化合物中去除的过程：##STR2## 其中R.sup.3是氢原子或羟基保护基团，R.sup.4和R.sup.5可能相同也可能不同，是从较低烷基基团和芳基烷基基团组成的羟基保护基团，以及X.sup..crclbar.是阴离子，N-保护基团（如有必要）与羟基保护基团一起。

  公开号：

  US04958029A1

文献信息

• Isoindoline derivatives and processes for their preparation
  申请人：Banyu Pharmaceutical Co., Ltd.

  公开号：US04987235A1

  公开（公告）日：1991-01-22

  A compound having the formula: ##STR1## wherein R is a hydrogen atom, a lower alkyl group, an alkanoyl group, an aralkyl group, an alkylsulfonyl group or an arylsulfonyl group, and R.sup.1 is a hydrogen atom or a protecting group for a hydroxyl group, or a salt thereof.

  一种具有以下化学式的化合物：##STR1## 其中R是氢原子、低碳烷基基团、烷酰基、芳基烷基基团、烷基磺酰基或芳基磺酰基，R.sup.1是氢原子或羟基的保护基，或其盐。
• Agents for promoting the proliferation or differentiation of stem cells or neural progenitor cells
  申请人：Okawa Shigenori

  公开号：US20090012081A1

  公开（公告）日：2009-01-08

  An agent for promoting the proliferation or differentiation of a stem cell and/or neural progenitor cell, comprising a compound represented by Formula: wherein each of R 1 and R 2 is H, a hydrocarbon group or a heterocyclic group, or taken together with the adjacent carbon atom to form a ring, R 3 is H, a hydrocarbon group or a heterocyclic group, W is a group represented by Formula: wherein Ring A is an optionally substituted benzene ring, Ring B is an optionally substituted 5- to 7-membered nitrogen-containing heterocyclic ring, R 4 is an acyl group having an aliphatic hydrocarbon group, which is substituted by an aromatic group and may have a further substitutent, or aromatic group, R 5 is H, C 1-6 alkyl or acyl, R 4c is an aromatic group, an aliphatic hydrocarbon group or acyl, and X is O or S; Y is O, S or NH, Ring C is an optionally substituted benzene ring, or a salt or prodrug thereof is provided.

  一种用于促进干细胞和/或神经祖细胞增殖或分化的药剂，包括由下式表示的化合物：其中R1和R2中的每一个是H、烃基或杂环基，或与相邻的碳原子结合形成环，R3是H、烃基或杂环基，W是由下式表示的基团：其中环A是可选取代的苯环，环B是可选取代的含氮杂环5-至7-元环，R4是取代芳基的脂肪族烃基的酰基，可以具有进一步的取代基或芳基，或者是芳基，R5是H、C1-6烷基或酰基，R4是芳基、脂肪族烃基或酰基，X是O或S；Y是O、S或NH，环C是可选取代的苯环，或其盐或前药。
• 2-AMINOTHIAZOLE-4-CARBOXYLIC AMIDES AS PROTEIN KINASE INHIBITORS
  申请人：Shipps, JR. Gerald W.

  公开号：US20100130465A1

  公开（公告）日：2010-05-27

  The present invention relates to novel Anilinopiperazine Derivatives of formula (I), compositions comprising the Anilinopiperazine Derivatives, and methods for using the Anilinopiperazine Derivatives for treating or preventing a proliferative disorder, an anti-proliferative disorder, inflammation, arthritis, a central nervous system disorder, a cardiovascular disease, alopecia, a neuronal disease, an ischemic injury, a viral disease, a fungal infection, or a disorder related to the activity of a protein kinase.

  本发明涉及一种新型的Anilinopiperazine衍生物的公式(I)，包括该Anilinopiperazine衍生物的组合物，并且使用该Anilinopiperazine衍生物治疗或预防增生性疾病、抗增生性疾病、炎症、关节炎、中枢神经系统疾病、心血管疾病、脱发、神经疾病、缺血性损伤、病毒性疾病、真菌感染或与蛋白激酶活性相关的疾病的方法。
• HETEROCYCLIC AMIDE COMPOUNDS AS PROTEIN KINASE INHIBITORS
  申请人：Reddy Panduranga Adulla P.

  公开号：US20120208826A1

  公开（公告）日：2012-08-16

  The present invention relates to heterocyclic amide derivatives of Formula (I): Formula (I) wherein the variables are as defined in the specification. The present invention further relates to compositions comprising said heterocyclic amide derivatives of formula (I) and methods for using said heterocyclic amide derivatives of formula (I) for treating or preventing a disease or disorder related to the activity of a protein kinase, in particular, a proliferative disease, an anti-proliferative disorder, inflammation, arthritis, a neurological or neurodegenerative disease, a cardiovascular disease, alopecia, a neuronal disease, an ischemic injury, a viral disease or a fungal infection.

  本发明涉及式(I)的杂环酰胺衍生物：式(I)其中变量如规范中所定义。本发明还涉及包含式(I)的上述杂环酰胺衍生物的组合物以及使用式(I)的上述杂环酰胺衍生物治疗或预防与蛋白激酶活性相关的疾病或障碍的方法，特别是增生性疾病、抗增生性障碍、炎症、关节炎、神经系统或神经退行性疾病、心血管疾病、脱发、神经疾病、缺血性损伤、病毒性疾病或真菌感染。
• Process for the production of isoindoline derivatives, novel intermediates and process for their production
  申请人：Banyu Pharmaceutical Co., Ltd.

  公开号：EP0275064A2

  公开（公告）日：1988-07-20

  A process for producing a compound of the formula: wherein R¹ is a hydrogen atom, a lower alkyl group or an aralkyl group, and R² is a hydrogen atom or a hydroxyl-protecting group, or a salt thereof, which comprises removing from a compound of the formula: wherein R³ is a hydrogen atom or a hydroxyl-protecting group, R⁴ and R⁵ which may be the same or different are N-protecting groups selected from the group consisting of lower alkyl groups and aralkyl groups, and X⊖ is an anion, the N-protecting group(s), if necessary, together with the hydroxyl-protecting group.

  一种生产式化合物的工艺： 其中R¹为氢原子、低级烷基或芳烷基，R²为氢原子或羟基保护基，或其盐的工艺，包括从式化合物中除去 其中 R³ 是氢原子或羟基保护基团，R⁴ 和 R⁵ 可以相同或不同，是选自由低级烷基和芳烷基组成的组的 N 保护基团，X⊖ 是阴离子。