O-(2-biphenylyl)hydroxylamine | 107449-13-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: O-(2-biphenylyl)hydroxylamine
• 英文别名: O-2-(Biphenylyl)hydroxylamine；O-(2-phenylphenyl)hydroxylamine
• CAS: 107449-13-8
• 化学式: C₁₂H₁₁NO
• 分子量: 185.225
• InChiKey: IQMVFUWEIKAIFF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  35.2
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  O-(2-biphenylyl)hydroxylamine 在 氘代三氟乙酸 作用下， 以 氘代氯仿 为溶剂， 生成 2-Amino-2-phenyl-3,5-cyclohexadienone
  参考文献：
  名称：

  O-（2-芳基苯基）羟胺的酸催化重排成芳基二氢a庚酮

  摘要：

  O-（2-芳基苯炔基）羟胺的酸催化重排，然后扩环，得到7-芳基-2，3-二氢-1H-氮杂-2-基。反应的中间体2-氨基-2-苯基-3，5-环己二酮被捕集为N-三氟乙酰胺。

  DOI：

  10.1016/s0040-4039(00)92083-5
• 作为产物：
  描述：

  2-([1,1'-biphenyl]-2-yloxy)isoindoline-1,3-dione 在 氨 作用下， 以 甲醇 为溶剂， 生成 O-(2-biphenylyl)hydroxylamine
  参考文献：
  名称：

  Design, synthesis, and antibacterial activities of novel 3,6-bicyclolide oximes: Length optimization and zero carbon linker oximes

  摘要：

  We designed and synthesized a series of novel 3,6-bicyclolide oximes, possessing linkers of varying lengths to the secondary binding site. The E isomers exhibited excellent antibacterial profiles against a broad spectrum of resistant pathogens. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2008.07.118

文献信息

• Chemistry of O-arylhydroxylamines. A novel acid-catalyzed rearrangement of O-aryl-N-acetoacetylhydroxylamines to benzofurans
  作者：Yasuyuki Endo、Kohshi Namikawa、Koichi Shudo

  DOI：10.1016/s0040-4039(00)84951-5

  日期：1986.1

  Acid-catalyzed rearangement of O-aryl-N-acetoacetylhydroxylamines (1) affords 2-methylbenzofuran-3-carboxamides. Some abnormal rearrangements of the title compounds are also described.

  酸催化的O-芳基-N-乙酰乙酰基羟胺的重整（1）得到2-甲基苯并呋喃-3-羧酰胺。还描述了标题化合物的一些异常重排。
• NOVEL DIARYLAMINE COMPOUND, AND ANTI-AGING AGENT, POLYMER COMPOSITION, CROSSLINKED RUBBER PRODUCT AND MOLDED ARTICLE THEREOF, AND METHOD FOR PRODUCING DIARYLAMINE COMPOUND
  申请人：Zeon Corporation

  公开号：EP2450348B1

  公开（公告）日：2016-12-14
• US4631333A
  申请人：——

  公开号：US4631333A

  公开（公告）日：1986-12-23
• Design, synthesis, and antibacterial activities of novel 3,6-bicyclolide oximes: Length optimization and zero carbon linker oximes
  作者：Datong Tang、Yonghua Gai、Alexander Polemeropoulos、Zhigang Chen、Zhe Wang、Yat Sun Or

  DOI：10.1016/j.bmcl.2008.07.118

  日期：2008.9

  We designed and synthesized a series of novel 3,6-bicyclolide oximes, possessing linkers of varying lengths to the secondary binding site. The E isomers exhibited excellent antibacterial profiles against a broad spectrum of resistant pathogens. (C) 2008 Elsevier Ltd. All rights reserved.
• Acid-catalyzed rearrangement of O-(2-arylphenyl)hydroxylamines to aryldihydroazepinones
  作者：Yasuyuki Endo、Ken-ichiro Kataoka、Naoki Haga、Koichi Shudo

  DOI：10.1016/s0040-4039(00)92083-5

  日期：1992.6

  Acid-catalyzed rearrangement of O-(2-arylpheynl) hydroxylamines followed by ring enlargement afford 7-aryl-2, 3-dihydro-1H-azepin-2-ones. 2-Amino-2-phenyl-3, 5-cyclohexadienone, an intermediate of the reaction, was trapped as the N-trifluoroacetamide.

  O-（2-芳基苯炔基）羟胺的酸催化重排，然后扩环，得到7-芳基-2，3-二氢-1H-氮杂-2-基。反应的中间体2-氨基-2-苯基-3，5-环己二酮被捕集为N-三氟乙酰胺。