(E)-3-phenyl-2-propenyl 1-naphthylmethyl ether | 98977-56-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: (E)-3-phenyl-2-propenyl 1-naphthylmethyl ether
• 英文别名: 1-((cinnamyloxy)methyl)naphthalene；E-(3-phenylallyl)-(1-naphthylmethyl)ether；1-[[(E)-3-phenylprop-2-enoxy]methyl]naphthalene
• CAS: 98977-56-1
• 化学式: C₂₀H₁₈O
• 分子量: 274.362
• InChiKey: LHNXWXJRTIOWSM-JXMROGBWSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5
• 重原子数：
  21
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  (E)-3-phenyl-2-propenyl 1-naphthylmethyl ether 在 [(SIPr)AgCl] 、 亚碘酰苯 、 C₄₂H₃₀Cl₂FeN₃O₂ 、 sodium hydride 、 二异丁基氢化铝 、 四(3,5-二(三氟甲基)苯基)硼酸钠 作用下， 以 四氢呋喃 、 乙醚 、 正己烷 、 二氯甲烷 为溶剂， 反应 2.5h， 生成 3-(1-naphthyl)-2-propen-1-ol
  参考文献：
  名称：

  具有类卟啉特性的非血红素铁 (III) 络合物可催化不对称环氧化

  摘要：

  在本报告中，我们描述了一种含有咔唑基三齿配体的铁 (III) 配合物，该配合物可在室温下催化 (E)-烯烃的高度对映选择性不对称环氧化。非血红素铁（III）配合物具有五配位三角双锥结构，其二电子氧化态具有与铁卟啉相似的电子结构。

  DOI：

  10.1021/ja304219s
• 作为产物：
  描述：

  1-萘甲醇 、 Cinnamyl bromide 在 sodium hydride 作用下， 生成 (E)-3-phenyl-2-propenyl 1-naphthylmethyl ether
  参考文献：
  名称：

  Synthesis and structure-activity relationships of naftifine-related allylamine antimycotics

  摘要：

  Naftifine (1) is the first representative of the new antifungal allylamine derivatives. Its biological activity is strictly bound to specific structural requirements that are unrelated to those of known antifungals. A tertiary allylamine function seems to be a prerequisite for activity against fungi. By systematic variation of the individual structural elements in 1, detailed structure-activity relationships are defined in which the phenyl ring is the structural feature permitting the widest variations. Versatile synthetic routes to allylamine derivatives and comparative biological data are presented.

  DOI：

  10.1021/jm00151a019

文献信息

• US4742077A
  申请人：——

  公开号：US4742077A

  公开（公告）日：1988-05-03
• Synthesis and structure-activity relationships of naftifine-related allylamine antimycotics
  作者：Anton Stuetz、Apostolos Georgopoulos、Waltraud Granitzer、Gabor Petranyi、Daniel Berney

  DOI：10.1021/jm00151a019

  日期：1986.1

  Naftifine (1) is the first representative of the new antifungal allylamine derivatives. Its biological activity is strictly bound to specific structural requirements that are unrelated to those of known antifungals. A tertiary allylamine function seems to be a prerequisite for activity against fungi. By systematic variation of the individual structural elements in 1, detailed structure-activity relationships are defined in which the phenyl ring is the structural feature permitting the widest variations. Versatile synthetic routes to allylamine derivatives and comparative biological data are presented.
• A Non-Heme Iron(III) Complex with Porphyrin-like Properties That Catalyzes Asymmetric Epoxidation
  作者：Takashi Niwa、Masahisa Nakada

  DOI：10.1021/ja304219s

  日期：2012.8.22

  In this report, we describe an iron(III) complex containing a carbazole-based tridentate ligand that catalyzes highly enantioselective asymmetric epoxidation of (E)-alkenes at room temperature. The non-heme iron(III) complex has a five-coordinated trigonal-bipyramidal structure, and its two-electron oxidized state has the similar electronic structure as that of iron porphyrins.

  在本报告中，我们描述了一种含有咔唑基三齿配体的铁 (III) 配合物，该配合物可在室温下催化 (E)-烯烃的高度对映选择性不对称环氧化。非血红素铁（III）配合物具有五配位三角双锥结构，其二电子氧化态具有与铁卟啉相似的电子结构。