2-mercapto-2'-hydroxybiphenyl | 79664-50-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-mercapto-2'-hydroxybiphenyl
• 英文别名: 2-(2-Sulfanylphenyl)phenol
• CAS: 79664-50-9
• 化学式: C₁₂H₁₀OS
• 分子量: 202.277
• InChiKey: GQWJBAXUTVBVDP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  14
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  21.2
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-mercapto-2'-hydroxybiphenyl 在 吡啶 作用下， 以 甲醇 为溶剂， 生成
  参考文献：
  名称：

  Convenient routes to 4,4''-functionalized o-terphenyls and 2,2'-functionalized biphenyls

  摘要：

  DOI：

  10.1021/jo00339a048
• 作为产物：
  描述：

  dibenzo[1,2]oxathiine-6-oxide 在 盐酸 、 lithium aluminium tetrahydride 作用下， 生成 2-mercapto-2'-hydroxybiphenyl
  参考文献：
  名称：

  Convenient routes to 4,4''-functionalized o-terphenyls and 2,2'-functionalized biphenyls

  摘要：

  DOI：

  10.1021/jo00339a048

文献信息

• [EN] CHIRALITY SENSING WITH MOLECULAR CLICK CHEMISTRY PROBES<br/>[FR] DÉTECTION DE CHIRALITÉ AVEC DES SONDES DE CHIMIE CLICK MOLÉCULAIRE
  申请人：UNIV GEORGETOWN

  公开号：WO2020028396A1

  公开（公告）日：2020-02-06

  The present invention relates to an analytical method that includes providing a sample potentially containing a chiral analyte that can exist in stereoisomeric forms, and providing a probe selected from the group consisting of coumarin-derived Michael acceptors, dinitrofluoroarenes and analogs thereof, arylsulfonyl chlorides and analogs thereof, arylchlorophosphines and analogs thereof, aryl halophosphites, and halodiazaphosphites. The sample is contacted with the probe under conditions to permit covalent binding of the probe to the analyte, if present in the sample; and, based on any binding that occurs, the absolute configuration of the analyte in the sample, and/or the concentration of the analyte in the sample, and/or the enantiomeric composition of the analyte in the sample is/are determined. The probe may be a coumarin-derived Michael acceptor, a di nitrofluoroarene or analog thereof, an arylsulfonyl chloride or analog thereof, an arylchlorophosphine or analog thereof, an aryl halophosphite, or a halodiazaphosphite.

  本发明涉及一种分析方法，包括提供一个潜在含有手性分析物的样品，该手性分析物可以存在于立体异构体形式中，并提供从香豆素衍生的Michael受体、二硝基氟芳烃及其类似物、芳基磺酰氯及其类似物、芳基氯代膦及其类似物、芳基卤代膦酸酯和卤代二氮磷酸酯组成的探针中选取的探针。将样品与探针在条件下接触，以允许探针与分析物共价结合，如果样品中存在分析物；基于发生的任何结合，确定样品中分析物的绝对构型，和/或样品中分析物的浓度，和/或样品中分析物的对映体组成。探针可以是香豆素衍生的Michael受体、二硝基氟芳烃或其类似物、芳基磺酰氯或其类似物、芳基氯代膦或其类似物、芳基卤代膦酸酯，或卤代二氮磷酸酯。
• [EN] QUANTITATIVE CHIRALITY AND CONCENTRATION SENSING OF CHIRAL ANALYTES USING A RELAY ASSAY<br/>[FR] DÉTECTION QUANTITATIVE DE CHIRALITÉ ET DE CONCENTRATION D'ANALYTES CHIRAUX À L'AIDE D'UN DOSAGE DE RELAIS
  申请人：UNIV GEORGETOWN

  公开号：WO2021225688A1

  公开（公告）日：2021-11-11

  The present application relates to an analytical method that includes providing a sample potentially containing a chiral analyte that can exist in stereoisomeric forms, providing certain probes; and providing an indicator. The sample is contacted with an excess of the probe under conditions to permit irreversible covalent binding of the probe to the analyte, if present in the sample. The sample is contacted with the indicator under conditions to permit covalent binding of the indicator to any excess probe that is not bound to the analyte. Based on any binding that occurs between the analyte and probe, the absolute configuration of the analyte in the sample and/or the enantiomeric composition of the analyte in the sample using a chiroptical technique is/are determined. Based on any binding that occurs between the indicator and probe, the concentration of the analyte in the sample is determined using a non-chiroptical technique.

  本申请涉及一种分析方法，包括提供可能含有立体异构体的手性分析物的样品，提供特定的探针和指示剂。在条件下，将样品与过量的探针接触，以允许探针与样品中存在的分析物不可逆共价结合。将样品与指示剂接触，以允许指示剂与未与分析物结合的任何剩余探针共价结合。基于分析物和探针之间的任何结合，使用手性光学技术确定样品中分析物的绝对构型和/或手性异构体组成。基于指示剂和探针之间的任何结合，使用非手性光学技术确定样品中分析物的浓度。
• Improved process for the preparation of mercaptomethylphenols
  申请人：Ciba Specialty Chemicals Holding Inc.

  公开号：EP1116714A1

  公开（公告）日：2001-07-18

  There is disclosed an improved process for the preparation of a compound of the formula I wherein n is 0 or 1, R1 is C1-C12alkyl or -CH2SR3, R2 is C1-C12alkyl, C7-C9phenylalkyl, C7-C9-phenylalkyl substituted on the phenyl radical by from 1 to 3 C1-C4alkyl groups; or -CH2SR3, R3 is C6-C18alkyl, phenyl or benzyl, R4 is hydrogen or methyl, R5 is hydrogen or methyl, with the proviso that R4 and R5 are not simultaneously methyl, by reacting a compound of the formula II wherein n, R4 and R5 are as previously defined, R11 is hydrogen or C1-C12alkyl; and R12 is hydrogen, C1-C12alkyl, C7-C9phenylalkyl, C7-C9phenylalkyl substituted on the phenyl radical by from 1 to 3 C1-C4alkyl groups; with formaldehyde or a compound that liberates formaldehyde under the reaction conditions and with at least one compound of the formula III         R3SH     (III) wherein R3 is as previously defined, in the presence of a base, said base being mono- or dimethylamine or mono- or diethylamine, which process comprises treating afterwards the reaction product with a reducing agent.

  本发明公开了一种制备式 I 化合物的改进工艺 其中 n 为 0 或 1，R1 为 C1-C12 烷基或-CH2SR3，R2 为 C1-C12 烷基、C7-C9 苯基、在苯基上被 1 至 3 个 C1-C4 烷基取代的 C7-C9 苯基；或-CH2SR3，R3 为 C6-C18 烷基、苯基或苄基，R4 为氢或甲基，R5 为氢或甲基，但 R4 和 R5 不同时为甲基，通过反应式 II 的化合物来制备。 其中 n、R4 和 R5 如前所定义，R11 是氢或 C1-C12烷基；R12 是氢、C1-C12烷基、C7-C9 苯基、苯基上被 1 至 3 个 C1-C4 烷基取代的 C7-C9 苯基；与甲醛或在反应条件下能释放甲醛的化合物以及至少一种式 III 的化合物进行反应 R3SH (III) 其中 R3 如前定义，在碱存在下，所述碱为一甲胺或二甲胺或一乙胺或二乙胺，该过程包括随后用还原剂处理反应产物。
• Transition-metal-free synthesis of 2-arylphenol via SNAr reaction of dibenzothiophene dioxide with KOH
  作者：Mamta Yadav、Ram Singh Jat、Sonu Kumari、Penke Vijaya Babu、Partha Roy、M. Bhanuchandra

  DOI：10.1016/j.tetlet.2023.154430

  日期：2023.4
• US8580399B2
  申请人：——

  公开号：US8580399B2

  公开（公告）日：2013-11-12