2-aminomethyl-1-methyl-pyridinium iodide | 1043461-14-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 2-aminomethyl-1-methyl-pyridinium iodide
• 英文别名: (1-Methylpyridin-1-ium-2-yl)methanamine;iodide
• CAS: 1043461-14-8
• 化学式: C₇H₁₁N₂*I
• 分子量: 250.082
• InChiKey: NZWUFAGSMFKOBR-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  -3.03
• 重原子数：
  10
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  29.9
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-aminomethyl-1-methyl-pyridinium iodide 、 水合茚三酮 以 甲醇 为溶剂， 反应 0.08h， 生成 diketohydrindylidenediketohydrindamine 、 2-Hydroxymethyl-1-methylpyridinium iodide
  参考文献：
  名称：

  Catalytic reduction of pralidoxime in pharmaceuticals by macrocyclic Ni(II) compounds derived from orthophthalaldehyde

  摘要：

  Efficient catalytic method for the reduction of pralidoxime to its amine derivative by macrocyclic Ni(II) compounds has been developed. Ten macrocyclic Schiff base Ni(II) compounds were synthesized via non-template synthesis by treating the corresponding macrocycles with nickel chloride in 1:1 ratio. The resulting compounds were characterized by elemental, IR, H-1 NMR, C-13 NMR, mass, electronic spectra, conductance, magnetic, thermal studies and their structures have been proposed. These compounds were used as catalysts for the reduction of pralidoxime to its amino derivative. The reduced pralidoxime was also characterized by spectral analysis and catalytic cycle has been established. The reduced product was determined spectrophotometrically by treating with ninhydrin reagent and the percent yields were found to be in the range of 75.12-82.36%. (C) 2007 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.saa.2007.10.014
• 作为产物：
  描述：

  pralidoxime iodide 在 ammonium formate 、 锌 作用下， 反应 0.17h， 以82.36%的产率得到2-aminomethyl-1-methyl-pyridinium iodide
  参考文献：
  名称：

  Catalytic reduction of pralidoxime in pharmaceuticals by macrocyclic Ni(II) compounds derived from orthophthalaldehyde

  摘要：

  Efficient catalytic method for the reduction of pralidoxime to its amine derivative by macrocyclic Ni(II) compounds has been developed. Ten macrocyclic Schiff base Ni(II) compounds were synthesized via non-template synthesis by treating the corresponding macrocycles with nickel chloride in 1:1 ratio. The resulting compounds were characterized by elemental, IR, H-1 NMR, C-13 NMR, mass, electronic spectra, conductance, magnetic, thermal studies and their structures have been proposed. These compounds were used as catalysts for the reduction of pralidoxime to its amino derivative. The reduced pralidoxime was also characterized by spectral analysis and catalytic cycle has been established. The reduced product was determined spectrophotometrically by treating with ninhydrin reagent and the percent yields were found to be in the range of 75.12-82.36%. (C) 2007 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.saa.2007.10.014

文献信息

• Catalytic reduction of pralidoxime in pharmaceuticals by macrocyclic Ni(II) compounds derived from orthophthalaldehyde
  作者：P. Muralidhar Reddy、Adapa V.S.S. Prasad、Rondla Rohini、Vadde Ravinder

  DOI：10.1016/j.saa.2007.10.014

  日期：2008.8

  Efficient catalytic method for the reduction of pralidoxime to its amine derivative by macrocyclic Ni(II) compounds has been developed. Ten macrocyclic Schiff base Ni(II) compounds were synthesized via non-template synthesis by treating the corresponding macrocycles with nickel chloride in 1:1 ratio. The resulting compounds were characterized by elemental, IR, H-1 NMR, C-13 NMR, mass, electronic spectra, conductance, magnetic, thermal studies and their structures have been proposed. These compounds were used as catalysts for the reduction of pralidoxime to its amino derivative. The reduced pralidoxime was also characterized by spectral analysis and catalytic cycle has been established. The reduced product was determined spectrophotometrically by treating with ninhydrin reagent and the percent yields were found to be in the range of 75.12-82.36%. (C) 2007 Elsevier B.V. All rights reserved.