N,N-diethylselenonicotinamide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: N,N-diethylselenonicotinamide
• 英文别名: N,N-diethylpyridine-3-carboselenoamide
• 化学式: C₁₀H₁₄N₂Se
• 分子量: 241.195
• InChiKey: XPWAIAIZMRLIRZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.07
• 重原子数：
  13
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  16.1
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  尼可刹米 在 草酰氯 、 LiAlHSeH 作用下， 以 乙醚 、 四氢呋喃 为溶剂， 反应 7.0h， 以36%的产率得到N,N-diethylselenonicotinamide
  参考文献：
  名称：

  从酰胺轻松合成 N,N-二烷基硒酰胺

  摘要：

  N,N-二烷基酰胺用草酰氯氯化，然后与 LiAlHSeH 反应，以中等至良好的产率得到相应的 N,N-二烷基硒酰胺。由于其空间位阻，带有庞大取代基的 N,N-二烷基酰胺没有转化为相应的硒酰胺。© 2002 Wiley Periodicals, Inc. 杂原子化学 13:195–198, 2002; 在线发表于 Wiley Interscience (www.interscience.wiley.com)。DOI 10.1002/hc.10016

  DOI：

  10.1002/hc.10016

文献信息

• Facile synthesis ofN,N-dialkylselenoamides from amides
  作者：Mamoru Koketsu、Yoshihiro Okayama、Hiroshi Aoki、Hideharu Ishihara

  DOI：10.1002/hc.10016

  日期：——

  N,N-Dialkylamides were chlorinated with oxalyl chloride and then allowed to react with LiAlHSeH to afford the corresponding N,N-dialkyselenoamides in moderate to good yields. The N,N-dialkylamides bearing bulky substituent groups were not converted into the corresponding selenoamides because of their steric hindrance. © 2002 Wiley Periodicals, Inc. Heteroatom Chem 13:195–198, 2002; Published online

  N,N-二烷基酰胺用草酰氯氯化，然后与 LiAlHSeH 反应，以中等至良好的产率得到相应的 N,N-二烷基硒酰胺。由于其空间位阻，带有庞大取代基的 N,N-二烷基酰胺没有转化为相应的硒酰胺。© 2002 Wiley Periodicals, Inc. 杂原子化学 13:195–198, 2002; 在线发表于 Wiley Interscience (www.interscience.wiley.com)。DOI 10.1002/hc.10016
• Tertiary selenoamide compounds are useful superoxide radical scavengers in vitro
  作者：Hitoe Takahashi、Atsuyoshi Nishina、Hirokazu Kimura、Kenji Motoki、Mamoru Koketsu、Hideharu Ishihara

  DOI：10.1016/j.ejps.2004.04.011

  日期：2004.11

  We investigated the scavenging effects of tertiary selenoamide compounds for super oxide radicals using a highly sensitive and quantitative chemiluminescence method. At 333 nM, tertiary selenoamide compounds scavenged 25.8-81.6% of O-2(-.).N-(Phenylselenocarbonyl) piperidine was the most effective scavenger of superoxide radicals. While N,N-diethyl-2-selenonaphthylamide and N,N-diethyl-4-chloroselenobenzamide was a moderately effective scavenger of superoxide radicals. The IC50 of N-(phenylselenocarbonyl) piperidine and N,N-diethyl-2-selenonaphthylamide were determined to be 110 and 182 nM, respectively. The results suggest that tertiary selenoamide compounds are useful scavengers of superoxide radicals. (C) 2004 Elsevier B.V. All rights reserved.