(2-(4-aminophenyl)acetyl)-N-allylamine

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (2-(4-aminophenyl)acetyl)-N-allylamine
• 英文别名: 2-(4-aminophenyl)-N-prop-2-enylacetamide
• 化学式: C₁₁H₁₄N₂O
• 分子量: 190.245
• InChiKey: FQWSZGGVEAELDD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  14
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  55.1
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  阿克他利 在 三氟化硼甲醇络合物 、 三乙胺 作用下， 以 甲醇 、 二氯甲烷 为溶剂， 反应 9.5h， 生成 (2-(4-aminophenyl)acetyl)-N-allylamine
  参考文献：
  名称：

  三氟化硼-甲醇络合物。温和而强大的试剂，可用于脱保护乙酰基胺。范围和选择性

  摘要：

  三氟化硼-甲醇络合物在对乙酰苯胺的脱乙酰作用中对常用的氨基保护基团表现出显着的脱保护选择性，并对底物的空间位阻高度敏感。探索了反应的范围和局限性。

  DOI：

  10.1016/j.tetlet.2015.12.087

文献信息

• OPHTHALMIC VISCOELASTIC DEVICE
  申请人：Carl Zeiss Meditec AG

  公开号：EP2846848A1

  公开（公告）日：2015-03-18
• Ophthalmic Viscoelastic Device
  申请人：Carl Zeiss Meditec AG

  公开号：US20150119356A1

  公开（公告）日：2015-04-30

  The invention relates to an ophthalmic viscoelastic device, comprising at least one viscoelastic polymer, wherein the at least one viscoelastic polymer is covalently bound to at least one phenolic compound. The invention also relates to a method for producing an ophthalmic viscoelastic device, in which at least one phenolic compound is covalently bound to at least one water-soluble, viscoelastic polymer.
• [EN] Ophthalmologic composition comprising an aqueous solution of at least one viscoelastic polysaccharide<br/>[FR] COMPOSITION OPHTALMOLOGIQUE COMPRENANT UNE SOLUTION AQUEUSE D'AU MOINS UN POLYSACCHARIDE VISCO-ÉLASTIQUE
  申请人：ZEISS CARL MEDITEC AG

  公开号：WO2013020917A1

  公开（公告）日：2013-02-14

  The invention relates to an ophthalmologic composition, comprising an aqueous solution of at least one viscoelastic polysaccharide, wherein the at least one polysaccharide is covalently bound to at least one dye. The invention also relates to a method for producing an ophthalmologic composition, in which at least one dye is covalently bound to at least one water-soluble, viscoelastic polysaccharide.
• [EN] OPHTHALMIC VISCOELASTIC DEVICE<br/>[FR] DISPOSITIF OPHTALMIQUE VISCOÉLASTIQUE
  申请人：ZEISS CARL MEDITEC AG

  公开号：WO2013167632A1

  公开（公告）日：2013-11-14

  The invention relates to an ophthalmic viscoelastic device, comprising at least one viscoelastic polymer, wherein the at least one viscoelastic polymer is covalently bound to at least one phenolic compound. The invention also relates to a method for producing an ophthalmic viscoelastic device, in which at least one phenolic compound is covalently bound to at least one water-soluble, viscoelastic polymer.
• Boron trifluoride–methanol complex. Mild and powerful reagent for deprotection of acetylated amines. Scope and selectivity
  作者：Sergey Miltsov、Vladimir Karavan、Alexandr Misharev、Julian Alonso-Chamarro、Mar Puyol

  DOI：10.1016/j.tetlet.2015.12.087

  日期：2016.2

  A boron trifluoride–methanol complex demonstrated remarkable deprotection selectivity against commonly used amino-protecting groups in the deacetylation of acetanilides and high sensitivity to the steric hindrance of substrates. The scope and limitations of the reaction were explored.

  三氟化硼-甲醇络合物在对乙酰苯胺的脱乙酰作用中对常用的氨基保护基团表现出显着的脱保护选择性，并对底物的空间位阻高度敏感。探索了反应的范围和局限性。