| 1643497-13-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• CAS: 1643497-13-5
• 化学式: C₄₄H₄₈Cl₂N₁₂NiO₄
• 分子量: 938.539
• InChiKey: RLOGHOPWPHWLCD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  None
• 重原子数：
  None
• 可旋转键数：
  None
• 环数：
  None
• sp3杂化的碳原子比例：
  None
• 拓扑面积：
  None
• 氢给体数：
  None
• 氢受体数：
  None

反应信息

• 作为产物：
  描述：

  nickel(II) acetate tetrahydrate 、 cozaar 以 水 为溶剂， 生成
  参考文献：
  名称：

  Molecular and supramolecular characterization of Ni(II)/losartan hydrophobic nanoprecipitate

  摘要：

  In this work, a contribution to understanding of the formation of metal(II)/losartan hydrophobic nanoprecipitate is reported. A Ni(II)/Los system was prepared and characterized in solid state and in solution. Solubility studies confirmed the formation of hydrophobic precipitate. Obtained spectroscopic data suggest a sort of coordination between tetrazolic ring as well as OH, and a D-4h geometry around the nickel cation. Thermodynamic studies demonstrated that complexation is a stepwise process, with equal enthalpic and entropic contributions for free energy of complexation. DLS and zeta potential titrations indicate the formation of stable nanoparticles of size and charge dependent on the molar ratio. Finally, theological studies demonstrate a Bingham plastic behavior for Ni(II)/Los suspension. (C) 2014 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.molstruc.2014.05.080