6-(bromoacetyl)amino-2,3-dimorpholinoquinoxaline | 220420-05-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 6-(bromoacetyl)amino-2,3-dimorpholinoquinoxaline
• 英文别名: 2-Bromo-N-(2,3-di-4-morpholinyl-6-quinoxalinyl)acetamide；2-bromo-N-(2,3-dimorpholin-4-ylquinoxalin-6-yl)acetamide
• CAS: 220420-05-3
• 化学式: C₁₈H₂₂BrN₅O₃
• 分子量: 436.308
• InChiKey: RSPGPZKLHJVKND-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  27
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  79.8
• 氢给体数：
  1
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  正癸酸 、 6-(bromoacetyl)amino-2,3-dimorpholinoquinoxaline 在 18-冠醚-6 、 potassium hydrogencarbonate 作用下， 以 乙腈 为溶剂， 反应 0.83h， 以98%的产率得到6-(O-decanoylhydroxyacetyl)amino-2,3-dimorpholinoquinoxaline
  参考文献：
  名称：

  Synthesis of 6-(Bromoacetyl)amino-2,3-dimorpholinoquinoxaline and Application to a New Fluorescence Derivatization Reagent of Fatty Acids for the High-Performance Liquid Chromatographic Analysis

  摘要：

  6-Amino-2,3-dimorpholinoquinoxaline (3) was allowed to react with bromoacetic acid in the presence of DCC to give 6-(bromoacetyl)amino-2,3-dimorpholinoquinoxaline (4). Five kinds of saturated fatty acids (C-10, C-12, C-14, C-16, and C-18) were subjected to the derivatization with compound (4) within 50 min to afford the corresponding fluorescent products (5a-e). All the peaks of the derivatized products clearly separated within 15 min. The detection limit of decanoic acid (C-10) was estimated to be 10 fmol/10 mu L injection volume (S/N=4).

  DOI：

  10.3987/com-98-s(h)47
• 作为产物：
  描述：

  2,3-dimorpholino-6-nitroquinoxaline 在 palladium on activated charcoal 氢气 、 三乙胺 作用下， 以 甲醇 、 二氯甲烷 为溶剂， 反应 2.25h， 生成 6-(bromoacetyl)amino-2,3-dimorpholinoquinoxaline
  参考文献：
  名称：

  Synthesis of 6-(Bromoacetyl)amino-2,3-dimorpholinoquinoxaline and Application to a New Fluorescence Derivatization Reagent of Fatty Acids for the High-Performance Liquid Chromatographic Analysis

  摘要：

  6-Amino-2,3-dimorpholinoquinoxaline (3) was allowed to react with bromoacetic acid in the presence of DCC to give 6-(bromoacetyl)amino-2,3-dimorpholinoquinoxaline (4). Five kinds of saturated fatty acids (C-10, C-12, C-14, C-16, and C-18) were subjected to the derivatization with compound (4) within 50 min to afford the corresponding fluorescent products (5a-e). All the peaks of the derivatized products clearly separated within 15 min. The detection limit of decanoic acid (C-10) was estimated to be 10 fmol/10 mu L injection volume (S/N=4).

  DOI：

  10.3987/com-98-s(h)47

文献信息

• Synthesis of 6-(Bromoacetyl)amino-2,3-dimorpholinoquinoxaline and Application to a New Fluorescence Derivatization Reagent of Fatty Acids for the High-Performance Liquid Chromatographic Analysis
  作者：Akira Katoh、Takeshi Fujimoto、Motoki Takahashi、Junko Ohkanda

  DOI：10.3987/com-98-s(h)47

  日期：——

  6-Amino-2,3-dimorpholinoquinoxaline (3) was allowed to react with bromoacetic acid in the presence of DCC to give 6-(bromoacetyl)amino-2,3-dimorpholinoquinoxaline (4). Five kinds of saturated fatty acids (C-10, C-12, C-14, C-16, and C-18) were subjected to the derivatization with compound (4) within 50 min to afford the corresponding fluorescent products (5a-e). All the peaks of the derivatized products clearly separated within 15 min. The detection limit of decanoic acid (C-10) was estimated to be 10 fmol/10 mu L injection volume (S/N=4).