(2-hexyliminomethyl)phenyl | 52944-89-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 英文名称: (2-hexyliminomethyl)phenyl
• 英文别名: 2‐[(hexylimino)methyl]phenol；N‐hexylsalicylimine；Salicylaldehyd-hexylimin；N-Hexyl-salicylaldimin；2-(Hexylimino-methyl)-phenol；N-n-hexylsalicylideneamine；N-hexylsalicylideneimine；6-[(Hexylamino)methylidene]cyclohexa-2,4-dien-1-one；2-(hexyliminomethyl)phenol
• CAS: 52944-89-5
• 化学式: C₁₃H₁₉NO
• 分子量: 205.3
• InChiKey: IPSFCGBCZOVXMY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  15
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.46
• 拓扑面积：
  32.6
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  (2-hexyliminomethyl)phenyl 、 dimethylgallium,hydrate 以 四氢呋喃 为溶剂， 以100%的产率得到κ(2)-N,O-2-n-hexyliminomethylphenolatodimethylgallium
  参考文献：
  名称：

  四配位二甲基镓化合物的水解稳定性各不相同

  摘要：

  通过氢氧化二甲基镓与双齿路易斯碱反应制备四配位的二甲基镓配合物，并评估其在水中分解的稳定性，这是确定其作为放射性药物（尤其是针对特定受体蛋白的药物）潜在用途的关键特性。由配体和氢氧化二甲基镓制备了六种结构类型的模型化合物，其中含有带有氧-氧，氧-氮和硫-氮供体原子的双齿配体。它们通过光谱学表征，在两种情况下通过X射线晶体学表征。稳定的百分比解络（CH 3）2镓+时在丙酮暴露于1000当量的水从路易斯碱部d通过1 H NMR测定的图6用作每种化合物的相对水解稳定性的量度。在我们研究的化合物中，在这些条件下的水解百分比为10％至100％，最水解稳定的化合物被证明是基于N-烷基水杨基醛二酸酯供体的那些。

  DOI：

  10.1021/om980413x
• 作为产物：
  描述：

  正己胺 、 水杨醛 以 二氯甲烷 为溶剂， 反应 10.0h， 以96%的产率得到(2-hexyliminomethyl)phenyl
  参考文献：
  名称：

  一种酚氧亚胺取代的钌络合物及其制备和应用

  摘要：

  本发明涉及一种酚氧亚胺取代的钌络合物及其制备和应用，该钌络合物的化学通式如下：其中，R1为C1～C20直链、支链或环状结构的烷基，或C7～C30的单或多芳基取代的烷基；R2～R5分别独立的为氢，或硝基，或C1～C20直链、支链的烷基，或C7～C30的单或多芳基取代的烷基，或C6～C18的芳基，或卤素。与现有技术相比，本发明可以实现双组分催化的效果，这样可以有效的控制聚合的开始，便于工业化操作，同时该催化剂具有耐水、氧、杂质的特点，此外，酚氧亚胺类配体合成简单，易于调节配体取代基的空间位阻和电子效应，可以有效调控金属中心钌的催化活性，从而实现对催化剂的有效调控。

  公开号：

  CN111909218A

文献信息

• Erbium(III) Triflate: A Valuable Catalyst for the Synthesis of Aldimines, Ketimines, and Enaminones
  作者：Renato Dalpozzo、Antonio De Nino、Monica Nardi、Beatrice Russo、Antonio Procopio

  DOI：10.1055/s-2006-926378

  日期：——

  and enaminones can be obtained under erbium(III) triflate catalysis. The reaction mechanism is that typical of imine synthesis. The role of the catalyst is demonstrated for the synthesis of aromatic imines. In contrast to CeCl 3 /NaI addition to unsaturated aldehydes, which results in Michael addition, no Michael adduct was observed under erbium(III) triflate catalysis.

  醛亚胺、酮亚胺和烯胺酮可以在三氟甲磺酸铒(III)催化下获得。反应机理是典型的亚胺合成。证明了催化剂在合成芳族亚胺方面的作用。与CeCl 3 /NaI 加成不饱和醛导致迈克尔加成相反，在三氟甲磺酸铒(III) 催化下没有观察到迈克尔加合物。
• IR, PMR and Mössbauer studies on the complexes of triphenyltin chloride and triphenyltin isothiocyanate with a series of N-alkylsalicylideneimines
  作者：Lian E. Khoo、Frank E. Smith

  DOI：10.1016/s0277-5387(00)87007-2

  日期：1985.1

  Abstract Eleven new complexes of the type Ph 3 SnX: o -HOC 6 H 4 CHNR (X = Cl, NCS; R = CH 3 , t -Bu, PhCH 2 , n -C 6 H 13 , c -C 6 H 11 , HOCH 2 CH 2 ) have been synthesized by the reactions of triphenyltin chloride or isothiocyanate with the N -alkylsalicylideneimines. The complexes are non-electrolytes in nitrobenzene. IR, PMR and Mossbauer spectroscopic studies indicate that the ligands are behaving

  摘要11种新的Ph 3 SnX络合物：o -HOC 6 H 4CHNR（X = Cl，NCS; R = CH 3，t-Bu，PhCH 2，n -C 6 H 13，c -C 6 H 11，HOCH 2 CH 2）已经通过三苯基氯化锡或异硫氰酸酯与N-烷基水杨叉二亚胺的反应合成。该络合物是硝基苯中的非电解质。IR，PMR和Mossbauer光谱研究表明，配体通过酚性氧原子表现为单齿状，并且配合物均具有三角双锥体几何结构，且苯基占据了赤道位置。
• Anti-mycobacterial activities of copper(II) salicylaldimine complexes derived from long-chain aliphatic amines
  作者：Alyssa E. Patterson、Eric G. Bowes、Allyson Bos、Taryn O’Neill、Haoxin Li、Andrew Flewelling、Christopher M. Vogels、Andreas Decken、Christopher A. Gray、Stephen A. Westcott

  DOI：10.1139/cjc-2013-0274

  日期：2013.11

  Twelve copper(II) Schiff base complexes derived from lipophilic amines have been prepared using either salicylaldehyde or ortho-vanillin via a microwave-assisted reaction. All complexes have been obtained elementally pure and an X-ray diffraction of an isopentyl derivative has confirmed the structure of these compounds. All complexes showed a promising degree of anti-mycobacterial activity against

  已经使用水杨醛或邻香兰素通过微波辅助反应制备了十二种衍生自亲脂胺的铜 (II) 席夫碱配合物。所有配合物均已获得元素纯，异戊基衍生物的 X 射线衍射证实了这些化合物的结构。所有复合物都显示出对结核分枝杆菌的有希望的抗分枝杆菌活性，其中活性似乎随着脂肪链长度的增加而增加。
• Structures of dichloromanganese(IV) complexes with bidentate and tetradentate Schiff base ligands
  作者：Hideyuki Asada、Manabu Fujiwara、Takayuki Matsushita

  DOI：10.1016/s0277-5387(00)00503-9

  日期：2000.9

  The dichloromanganese(IV) complexes with various bidentate and tetradentate Schiff base ligands, Mn-IV(L'),Cl-2 and Mn-IV(L)Cl-2 have been obtained by the reactions of chloromanganese(III) complexes, Mn-III(L')(2)Cl and Mn-III(L)Cl with hydrogen chloride or by the reactions of acetatomanganese(III) complexes, Mn-III(L')(2)OAc, with chlorine as deep green crystals, where L'H denotes bidentate Schiff base ligands N-R-salH (N-alkyl-salicylideneamine) and R can be n-C3H7, n-C6H13, n-C8H17, or n-C12H25, and LH, denotes tetradentate Schiff base ligands X-salenH, (N,N'-disubstituted-salicylideneethylenediamine) or X-salpnH(2) (N,N'-disubstituted salicylidenepropanediamine) and X can be H and 5-Br. X-ray structure analysis of the present dichloromanganese(IV) complexes has revealed that two chloride ions coordinate to the central manganese ion in a trans-form. (C) 2000 Elsevier Science Ltd. All rights reserved.
• Synthesis, characterization and anticancer properties of (salicylaldiminato)platinum(II) complexes
  作者：Alyssa E. Patterson、Jessica J. Miller、Brittany A. Miles、Erin L. Stewart、Josée-Marie E.J. Melanson、Christopher M. Vogels、Amanda M. Cockshutt、Andreas Decken、Pier Morin、Stephen A. Westcott

  DOI：10.1016/j.ica.2014.02.028

  日期：2014.5

  Twelve new (salicylaldiminato) platinum(II) complexes have been prepared, characterized and examined for their in vitro cytotoxic properties against three human glioma cell lines LN18, LN405 and Hs683. Initial biotesting was done on platinum complexes 1-6, which display a wide range of physicochemical properties. Whereas introduction of aromatic rings in the complexes did not seem to have a significant impact on bioactivities, the length of the aliphatic group positively correlated with cytotoxicity in all cell lines. Complexes 2 and 3 were found to be particularly potent against LN18 cells as demonstrated by stronger cell growth inhibition when compared to cisplatin. These initial findings led us to develop an additional series of mono (salicylaldiminato) platinum(II) complexes 7-12, which were subjected to additional cytotoxicity studies but were less cytotoxic compared to the bis Schiff base complexes. These organometallic compounds could serve as interesting starting points for the development of novel therapeutic strategies to treat brain tumors. (C) 2014 Elsevier B.V. All rights reserved.