(2-巯基乙基)三甲基氯化铵 | 37880-96-9

• 分子结构分类: 有机化合物 - 有机氮化合物
• 中文名称: (2-巯基乙基)三甲基氯化铵
• 英文名称: thiocholine chloride
• 英文别名: (2-mercaptoethyl)trimethylammonium chloride；2-(Trimethylazaniumyl)ethane-1-thiolate--hydrogen chloride (1/1)；2-(trimethylazaniumyl)ethanethiolate;hydrochloride
• CAS: 37880-96-9
• 化学式: C₅H₁₄NS*Cl
• mdl: MFCD00871741
• 分子量: 155.692
• InChiKey: JKUAUCQIEHEDSL-UHFFFAOYSA-N

物化性质

• 熔点：
  238 °C

计算性质

• 辛醇/水分配系数(LogP)：
  -3.57
• 重原子数：
  8
• 可旋转键数：
  2
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  1
• 氢给体数：
  1
• 氢受体数：
  2

安全信息

• 海关编码：
  2930909090

反应信息

• 作为反应物：
  描述：

  1-allyl-3-ethylimidazolium chloride 、 (2-巯基乙基)三甲基氯化铵 在 三苯基膦 作用下， 以 乙醇 为溶剂， 反应 48.0h， 生成
  参考文献：
  名称：

  一种制备1-氯乙醛肟的方法

  摘要：

  该发明涉及1‑氯乙醛肟制备技术领域，具体关于一种制备1‑氯乙醛肟的方法；该发明提供一种制备1‑氯乙醛肟的方法，通过巯基迈克尔加成反应制备一种多氯代氯加合离子液，该多氯代氯加合离子液与乙醛肟相容性好，其含氯量大于32%，可以进一步的保证乙醛肟的氯化效率，提升1‑氯乙醛肟的收率和产品纯度。

  公开号：

  CN114409567A
• 作为产物：
  描述：

  矮壮素 在 sodium thiosulfate 、 盐酸 作用下， 以 水 为溶剂， 反应 15.0h， 以40%的产率得到(2-巯基乙基)三甲基氯化铵
  参考文献：
  名称：

  Facile Conversion of Cysteine and Alkyl Cysteines to Dehydroalanine on Protein Surfaces: Versatile and Switchable Access to Functionalized Proteins

  摘要：

  An efficient and robust oxidative elimination of cysteine to dehydroalanine has been discovered. The reaction is induced by O-mesitylenesulfonylhydroxylamine (MSH) and is compatible with methionine. The key elimination has been executed on protein surfaces and allows ready access to different post-translationally modified proteins through conjugate addition of sulfur nucleophiles to dehydroalanine. Treatment of the resulting thioether with MSH results in regeneration of dehydroalanine, allowing a "functional switch" by subsequent addition of a different thiol.

  DOI：

  10.1021/ja800800p

文献信息

• GLYCOPEPTIDE AND LIPOGLYCOPEPTIDE ANTIBIOTICS WITH IMPROVED SOLUBILITY
  申请人：Rafai Far Adel

  公开号：US20120149632A1

  公开（公告）日：2012-06-14

  The invention relates to derivatives of glycopeptide and lipoglycopeptide antibiotics possessing an altered ionization state with respect to the parent glycopeptide or lipoglycopeptide antibiotic, and having the ability to be regenerated as the parent glycopeptide or lipoglycopeptide antibiotic under physiological conditions. These compounds are useful as antibiotics for the prevention and/or the treatment of bacterial infections.

  这项发明涉及具有与母体糖肽或脂质糖肽抗生素相比具有改变的电离状态的糖肽和脂质糖肽抗生素衍生物，并且具有在生理条件下能够再生为母体糖肽或脂质糖肽抗生素的能力。这些化合物可用作预防和/或治疗细菌感染的抗生素。
• Conversion of Cysteine into Dehydroalanine Enables Access to Synthetic Histones Bearing Diverse Post-Translational Modifications
  作者：Justin M. Chalker、Lukas Lercher、Nathan R. Rose、Christopher J. Schofield、Benjamin G. Davis

  DOI：10.1002/anie.201106432

  日期：2012.2.20

  Six for the price of one: From a single precursor, dehydroalanine, six distinct post‐translational modifications can be site‐selectively installed on histone proteins (see figure), including the first site‐selective phosphorylation and glycosylation of histones. Direct observation of histone deacetylase activity on a full‐length modified histone as well as its interactions with both chromatin reader

  六个的价格：从一个单一的前体脱氢丙氨酸，六个不同的翻译后修饰可以位点选择性地安装在组蛋白上（见图），包括组蛋白的第一个位点选择性磷酸化和糖基化。报告了对全长修饰组蛋白的组蛋白脱乙酰酶活性的直接观察及其与染色质读取器和写入器/擦除器蛋白的相互作用。
• Accelerated reduction and solubilization of elemental sulfur by 1,2-aminothiols
  作者：Jonathan T. Stoffel、Kimberly T. Riordan、Emily Y. Tsui

  DOI：10.1039/d1cc05242j

  日期：——

  Nucleophilic 1,2-aminothiol compounds readily reduce typically-insoluble elemental sulfur to polysulfides in both water and nonpolar organic solvents. The resulting anionic polysulfide species are stabilized through hydrogen-bonding interactions with the proximal amine moieties. These interactions can facilitate sulfur transfer to alkenes.

  在水和非极性有机溶剂中，亲核 1,2-氨基硫醇化合物很容易将通常不溶的元素硫还原为多硫化物。所得阴离子多硫化物物质通过与近端胺部分的氢键相互作用而稳定。这些相互作用可以促进硫转移到烯烃。
• Enzymatic Spectrophotometric Method for Aflatoxin B Detection Based on Acetylcholinesterase Inhibition
  作者：Fabiana Arduini、Ilenia Errico、Aziz Amine、Laura Micheli、Giuseppe Palleschi、Danila Moscone

  DOI：10.1021/ac061819j

  日期：2007.5.1

  A new method for aflatoxin B (AFB) determination is proposed. The AFB determination is based on acetylcholinesterase (AChE) inhibition, and the AChE residual activity is determined using the colorimetric method (Ellman's method). Cholinesterases (ChEs) from various sources were tested using AFB1 as reference aflatoxin. AChE from electric eel has shown the highest sensitivity to AFB1, and it was chosen for the rest of the work. To select and optimize the analytical procedures, an investigation on the type of AChE inhibition by AFB1 was carried out. The AChE degree of inhibition by AFB1 was independent of the incubation time and the enzyme concentrations, showing the reversibility of the inhibition. This reversibility of the inhibition permits a rapid analysis of AFB1, requiring only 3 min. For the development of the AFB1 assay, the pH, the time of reaction, temperature, and substrate concentration were evaluated and optimized. The linear range of 10−60 ng mL-1 was determined. To evaluate the selectivity of this method, the cross-reactivity with other aflatoxins such as aflatoxin B2, aflatoxin G1, aflatoxin G2, and aflatoxin M1 was investigated. Finally, the suitability of the assay for AFB1 quantification in barley was evaluated. This study shows a new approach to detect aflatoxins based on enzyme inhibition and has advantages such as the ease of use, rapidity, and cost effectiveness. Thus, it could find a possible use as a screening method for this type of mycotoxins.

  本文提出了一种测定黄曲霉毒素 B（AFB）的新方法。AFB 的测定以乙酰胆碱酯酶（AChE）抑制作用为基础，用比色法（埃尔曼法）测定乙酰胆碱酯酶的残余活性。以 AFB1 作为参考黄曲霉毒素，对不同来源的胆碱酯酶（ChEs）进行了测试。电鳗中的乙酰胆碱酯酶对 AFB1 的敏感性最高，因此被选为后续研究的对象。为了选择和优化分析程序，对 AFB1 对 AChE 的抑制类型进行了调查。AFB1 对 AChE 的抑制程度与孵育时间和酶浓度无关，这表明抑制作用具有可逆性。这种抑制的可逆性使 AFB1 的快速分析成为可能，只需 3 分钟。为开发 AFB1 检测方法，对 pH 值、反应时间、温度和底物浓度进行了评估和优化。该方法的线性范围为 10-60 毫微克/毫升。为了评估该方法的选择性，研究了与其他黄曲霉毒素（如黄曲霉毒素 B2、黄曲霉毒素 G1、黄曲霉毒素 G2 和黄曲霉毒素 M1）的交叉反应。最后，还评估了该检测方法对大麦中 AFB1 定量的适用性。这项研究展示了一种基于酶抑制作用检测黄曲霉毒素的新方法，具有使用方便、快速和成本效益高等优点。因此，该方法可用作这类霉菌毒素的筛选方法。
• One-pot preparation of cationic charged Pt nanoparticles by the autocatalytic hydrolysis of acetylthiocholine
  作者：Yohei Ishida、Thatchanont Jirasupangkul、Tetsu Yonezawa

  DOI：10.1039/c5nj00420a

  日期：——

  Autocatalytic synthesis of cationic charged platinum nanoparticles.

  阳离子带电铂纳米颗粒的自催化合成。