7-methoxy-3,4-dimethylcoumarin | 13252-88-5

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 香豆素及其衍生物
• 英文名称: 7-methoxy-3,4-dimethylcoumarin
• 英文别名: 7-methoxy-3,4-dimethyl-coumarin；7-Methoxy-3,4-dimethyl-cumarin；7-Methoxy-3,4-dimethylcumarin；7-methoxy-3,4-dimethyl-2H-chromen-2-one；7-methoxy-3,4-dimethylchromen-2-one
• CAS: 13252-88-5
• 化学式: C₁₂H₁₂O₃
• mdl: MFCD00871717
• 分子量: 204.225
• InChiKey: JDNSAFIIOVPTOF-UHFFFAOYSA-N

物化性质

• 熔点：
  140 °C
• 沸点：
  346.5±37.0 °C(Predicted)
• 密度：
  1.153±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  15
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  35.5
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  7-methoxy-3,4-dimethylcoumarin 在 chlorosulphuric acid 作用下， 生成 7-methoxy-3,4-dimethyl-2-oxo-2H-chromene-6-sulfonic acid anilide
  参考文献：
  名称：

  Substitution in the Benzopyrone Series. IV. Sulfonation of Coumarin Derivatives

  摘要：

  DOI：

  10.1021/jo01359a007
• 作为产物：
  描述：

  2,4-二甲氧基苯乙酮 在 硫酸 、 锌 、 苯 作用下， 生成 7-methoxy-3,4-dimethylcoumarin
  参考文献：
  名称：

  Herniation through both Winslow’s foramen and a lesser omental defect: Report of a case

  摘要：

  The herniation of small bowel through Winslow's foramen is a rare type of internal hernia which ran cause ileus; however, a hernia traversing the lesser sac is even more unusual. To the best of our knowledge, only 25 cases of herniation through Winslow's foramen and 10 cases of lesser sac hernia have been reported in the Japanese literature. We describe herein the case of a 33-year-old man who presented to our hospital complaining of abdominal pain in whom a plain abdominal radiograph revealed small bowel gas with air-fluid levels, suggesting ileus. Following admission, an ileus tube was inserted, but the intestinal shadow did not improve and surgery was performed based on suspicion of an internal hernia. Approximately 100 cm of ileum was found to have herniated through a defect in the lesser omentum after passing through Winslow's foramen, Since the herniated bowel was viable, manual reduction without resection was performed. The patient had a satisfactory postoperative course, and was discharged on postoperative day 11, There are many unknown aspects surrounding the etiology of Winslow's foramen hernia and lesser sac hernia, and although internal hernia is a rare cause of ileus, its possibility should be kept in mind.

  DOI：

  10.1007/s005950070125

文献信息

• Strong Antibiotic Activity of the Myxocoumarin Scaffold <i>in vitro</i> and <i>in vivo</i>
  作者：Gesa Hertrampf、Kalina Kusserow、Sandra Vojnovic、Aleksandar Pavic、Jonas I. Müller、Jasmina Nikodinovic‐Runic、Tobias A. M. Gulder

  DOI：10.1002/chem.202200394

  日期：2022.6.7

  human health. The discovery of new compounds with potent antibiotic activity is thus of utmost importance. Within this work, we identify strong antibiotic activity of the natural product myxocoumarin B from Stigmatella aurantiaca MYX-030 against a range of clinically relevant bacterial pathogens, including clinical isolates of MRSA. A focused library of structural analogs was synthesized to explore initial

  对现有抗生素的耐药性不断出现，对人类健康构成重大威胁。因此，发现具有有效抗生素活性的新化合物至关重要。在这项工作中，我们鉴定了来自 Stigmatella aurantiaca MYX-030 的天然产物粘香豆素 B 对一系列临床相关细菌病原体（包括 MRSA 的临床分离株）的强大抗生素活性。合成了一个重点结构类似物库，以探索初始结构-活性关系，并鉴定不含天然硝基取代基的等效粘香豆素衍生物，以显着简化合成途径。使用斑马鱼模型系统确定了粘香豆素的细胞毒性及其治疗体内细菌感染的潜力。我们的结果揭示了粘香豆素支架的特殊抗生素活性及其开发新型抗生素的潜力。
• PHOTOPOLYMERIZATION INITIATOR, PHOTOCURABLE COMPOSITION, CURED PRODUCT, AND DENTAL MATERIAL
  申请人：Mitsui Chemicals, Inc.

  公开号：EP3895681A1

  公开（公告）日：2021-10-20

  A photopolymerization initiator including a peroxide, a photobase generator, and a photoradical generator; a photocurable composition; a cured product; and a dental material.

  一种光聚合引发剂，包括过氧化物、光碱发生器和光二极体发生器；一种光固化组合物；一种固化产品；以及一种牙科材料。
• Canter et al., Journal of the Chemical Society, 1931, p. 1255,1264
  作者：Canter et al.

  DOI：——

  日期：——
• Naik; Jadhav, Journal of the Indian Chemical Society, 1949, vol. 26, p. 245
  作者：Naik、Jadhav

  DOI：——

  日期：——
• Heilbron et al., Journal of the Chemical Society, 1936, p. 295,299, 300
  作者：Heilbron et al.

  DOI：——

  日期：——