1,4-bis(4-acetamidophenoxy)butane | 104209-31-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1,4-bis(4-acetamidophenoxy)butane
• 英文别名: 1,4-bis-(4-acetylamino-phenoxy)-butane；1,4-Bis-(4-acetylamino-phenoxy)-butan；Acetamide, N,N'-[1,4-butanediylbis(oxy-4,1-phenylene)]bis-；N-[4-[4-(4-acetamidophenoxy)butoxy]phenyl]acetamide
• CAS: 104209-31-6
• 化学式: C₂₀H₂₄N₂O₄
• 分子量: 356.422
• InChiKey: JYFHRGNXCXTTBR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  26
• 可旋转键数：
  9
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  76.7
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  1,4-bis(4-acetamidophenoxy)butane 在 sodium hydroxide 、 四丁基氢氧化铵 、 potassium carbonate 作用下， 以 水 、 乙二醇 、 丁酮 为溶剂， 反应 10.0h， 生成 1,4-bisbutane
  参考文献：
  名称：

  N-(2-Methyl-2-nitropropyl) and N-Nitroso Derivatives of Some Diamines

  摘要：

  介绍了十种新的1,6-己二胺和1,4-双(4-氨基苯氧基)丁烷衍生物的制备，它们具有不同组合的N-亚硝基和/或N-(2-甲基-2-硝基丙基)基团。这些标题化合物可能是硫化橡胶动态性能的潜在改进剂。

  DOI：

  10.1135/cccc19951541
• 作为产物：
  描述：

  1-硝基-4-[4-(4-硝基苯氧基)丁氧基]苯 生成 1,4-bis(4-acetamidophenoxy)butane
  参考文献：
  名称：

  Ashley et al., Journal of the Chemical Society, 1958, p. 3298,3308

  摘要：

  DOI：

文献信息

• Thermal and mechanical properties of azomethine functionalized cyanate ester/epoxy blends
  作者：C. P. Sakthidharan、P. R. Sundararajan、M. Sarojadevi

  DOI：10.1039/c4ra16004e

  日期：——

  azomethine functionalized diols were synthesized by the condensation reaction of aromatic diamines with 4-hydroxy benzaldehyde. Aromatic diamines with different alkyl chain lengths have been used to prepare the bisphenols. These bisphenols were converted to their corresponding cyanate esters by treating with cyanogen bromide (CNBr) in the presence of triethyl amine (Et3N). The curing temperature was measured

  通过芳族二胺与4-羟基苯甲醛的缩合反应合成了一系列偶氮甲碱官能化的二醇。具有不同烷基链长的芳族二胺已用于制备双酚。通过在三乙胺（Et 3 N）存在下用溴化氰（CNBr）处理，将这些双酚转化为相应的氰酸酯。使用差示扫描量热法（DSC）测量固化温度。这些氰酸酯的最高固化温度为203–242°C。使用热重分析（TGA）研究了固化的氰酸酯的热性能。聚合物显示出优异的热稳定性（T 5％在358至465°C的范围内，T发现10％在508至525°C的范围内，而在800°C下的焦炭收率百分比在37.06至57.26的范围内。使用极限氧指数值（在800°C下在32.32至40.40的范围内）评估氰酸酯树脂的阻燃性。制备了氰酸酯/环氧树脂混合物，并通过扫描电子显微镜研究了混合物的形态。使用动态力学分析（DMA）研究了氰酸酯/环氧酯共混物的机械性能和玻璃化转变温度，发现T g随着氰酸酯含量的增加（1-5％）而增加。
• Self-assembly of bis-[1]rotaxanes based on diverse thiourea-bridged mono-functionalized dipillar[5]arenes
  作者：Lu Yang、Cui-Yun Nie、Ying Han、Jing Sun、Chao-Guo Yan

  DOI：10.1007/s10847-021-01103-4

  日期：2022.2

  pillar[5]arenes with 1,ω-bis(4-isothiocyanatophenoxy)alkanes also afforded diphenoxyalkylene thiourea-bridged dipillar[5]arenes. 1H NMR and NOESY spectra clearly indicated that bis-[1]rotaxanes were formed by insertion of longer alkylene chains into the cavities of two pillar[5]arenes. On the other hand, the free-forms of dipillar[5]arenes were obtained with the shorter ethylene chains existing on the outside

  单酰胺官能化柱的缩合反应[5]与芳烃TERE -和异下超声波照射，得到在丙酮-phthaloyl二异硫氰酸酯TERE -和异-phthaloylthiourea-桥接dipillar [5]芳烃。单酰氨基官能化的柱[5]芳烃与1,ω-双(4-异硫氰酸根合苯氧基)烷烃的类似反应也提供了二苯氧基亚烷基硫脲桥连的双柱[5]芳烃。1H NMR 和 NOESY 光谱清楚地表明双-[1] 轮烷是通过将较长的亚烷基链插入两个柱[5] 芳烃的空腔而形成的。另一方面，自由形式的二柱[5]芳烃是在两个柱[5]芳烃的空腔外侧存在较短的乙烯链的情况下获得的。 图形摘要
• Griffin; Britt; Hung, Molecular Crystals and Liquid Crystals (1969-1991), 1983, vol. 105, # 1-4, p. 305 - 314
  作者：Griffin、Britt、Hung、Steele

  DOI：——

  日期：——
• Biological properties of amidinium sulfinic and sulfonic acid derivatives: inhibition of glycolytic enzymes of Trypanosoma brucei and protective effect on cell growth
  作者：M Willson、JJ Périé、F Malecaze、F Opperdoes、M Callens

  DOI：10.1016/0223-5234(92)90114-g

  日期：1992.11

  The activity of the title compounds has been investigated on two biological targets: cultures of trypanosome and glycolytic enzymes inhibition of the parasite, and on retinal epithelium cells. In both cases, these compounds exhibit a significant activity, in some cases more selective than this for the drug suramin, with a lower toxicity. The effect of these compounds, which exist as neutral and zwitterionic forms in the case of sulfinic, only as zwitterionic in the case of sulfonic derivatives can be understood via their action on clusters of positive charges which are present at the surface of the proteins involved in the processes: glycolytic enzymes of the trypanosome in the first part, basic fibroblast growth factor in the second.