双(丙腈基)二氯硅烷 | 1071-08-5

• 分子结构分类: 有机化合物 - 有机卤素化合物 - 有机氯化物
• 中文名称: 双(丙腈基)二氯硅烷
• 英文名称: 1,1,1,3,4-pentachlorobutane
• 英文别名: 1,1,1,3,4-pentachloro-butane；1,1,1,3,4-Pentachlor-butan；1,1,1,3,4-Pentachlorbutan；Heptachlorpentan
• CAS: 1071-08-5
• 化学式: C₄H₅Cl₅
• 分子量: 230.349
• InChiKey: WKGSGSWERJVAAR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  9
• 可旋转键数：
  2
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  0

反应信息

• 作为反应物：
  描述：

  双(丙腈基)二氯硅烷 在 盐酸 、 锌 作用下， 以 乙醇 为溶剂， 生成 1,2-二氯丁烷
  参考文献：
  名称：

  Synthesis of cylclopropanes by reductive cyclization of polychloroalkanes containing a CCl3 OR CCl2 group

  摘要：

  DOI：

  10.1007/bf00925884
• 作为产物：
  描述：

  3-氯丙烯 生成 双(丙腈基)二氯硅烷
  参考文献：
  名称：

  TSURUTANI, TEHTSUO;SATO, MASASI;XORIUTI, TOKIO;KUBO, XIRODZI;INOMATA, DZE+

  摘要：

  DOI：

文献信息

• The Reaction of Polyhalides with Allylsilanes Catalyzed by Copper(I) Chloride
  作者：Michiharu Mitani、Shigenori Hujita

  DOI：10.1246/bcsj.70.3055

  日期：1997.12

  compounds in the presence of copper species, such as copper(I) chloride, copper(II) chloride or metallic copper, to form polyhalo compounds containing an allyl group. Other allylsilane derivatives than allyltrimethylsilane were also subjected to a reaction with carbon tetrachloride. 3-Chloro- or 3-bromo-3-trimethylsilyl-1-propene gave 4,4,4-trichloro-1-trimethylsilyl-1-butene. Ethyl 1-trimethylsilylallyl

  烯丙基三甲基硅烷在铜物质（例如氯化铜（I）、氯化铜（II）或金属铜）存在下与多卤化合物反应，形成含有烯丙基的多卤化合物。除了烯丙基三甲基硅烷之外的其他烯丙基硅烷衍生物也与四氯化碳反应。3-氯-或3-溴-3-三甲基甲硅烷基-1-丙烯得到4,4,4-三氯-1-三甲基甲硅烷基-1-丁烯。碳酸1-三甲基甲硅烷基烯丙酯乙酯提供碳酸乙酯4,4,4-三氯-1-丁烯酯以及氢三氯甲基化产物。2-甲基-3-三甲基甲硅烷基-1-丙烯基于添加三氯甲基基团然后从2-甲基基团消除氢产生产物。
• SUSTAINED RELEASE COMPOSITIONS
  申请人：Takeda Chemical Industries, Ltd.

  公开号：EP1291023A1

  公开（公告）日：2003-03-12

  A composition prepared by containing or blending a physiologically active non-peptide substance and a biodegradable polymer having two or more carboxylic groups at its end or a salt thereof features: (1) larger content of the physiologically active non-peptide substance can be contained, as well as release of the same can be controlled or accelerated, whereby secure pharmaceutical effect is achieved; (2) when the physiologically active non-peptide substance causes subcutaneous stimulation, an activity of canceling the stimulation by strongly acidic group at its end is expected; and (3) high glass transition point and high stability.

  通过含有或混合生理活性非肽物质和具有两个或两个以上羧基末端的可生物降解聚合物或其盐制备的组合物具有以下特点：（1）可以含有更多生理活性非肽物质，并且可以控制或加速其释放，从而实现安全的药效；（2）当生理活性非肽物质引起皮下刺激时，预计具有在其末端具有强酸性基团的活性来取消刺激；以及（3）高玻璃转变温度和高稳定性。
• Telomerisation par catalyse redox—VIII
  作者：M. Corallo、Y. Pietrasanta

  DOI：10.1016/0040-4020(76)88004-0

  日期：1976.1

  The syntheses of 2:1-adducts from carbon tetrachloride with non-conjugated dienes were realised by redox catalysis. However, in some cases, predominant 1:1-adduct formation was observed, as well as degradation and polymerisation reactions.

  四氧化碳与非共轭二烯的2：1-加合物的合成是通过氧化还原催化实现的。但是，在某些情况下，观察到主要形成1：1加合物，以及降解和聚合反应。
• Monomers, polymers and ophthalmic lenses
  申请人：——

  公开号：US20040198938A1

  公开（公告）日：2004-10-07

  This invention has the objective of providing polymers having high oxygen permeability and high hydrophobicity and ophthalmic lenses comprising said polymers, and, as a result, provides novel monomers represented by general formula (a) below: 1 wherein, in formula (a), A 1 to A 9 indicate groups selected from the group consisting of H, alkyl groups, aralkyl groups, aryl groups and alkyl groups having 1 to 9 carbon atoms substituted with at least one group selected from epoxy groups, hydroxyl groups and amino groups, with at least one of A 1 to A 9 indicating said alkyl group of 1 to 9 carbon atoms substituted with at least one group selected from epoxy groups, hydroxyl groups and amino groups; a, b and c indicate 0 or 1; X indicates a polymerizable group having a carbon-carbon unsaturated bond; Z indicates groups selected from N—Y, O and S; Y indicates H, an alkyl group or an aryl group; and L indicates a divalent group having 1 to 10 carbon atoms.

  该发明旨在提供具有高氧气渗透性和高疏水性的聚合物以及包括该聚合物的眼科透镜，因此提供了以下通式（a）所代表的新型单体： 其中，在式（a）中，A1到A9表示从H、烷基、芳基烷基、芳基和烷基中选择的基团，该烷基具有1到9个碳原子，被至少一个从环氧基团、羟基团和氨基团中选择的基团取代，其中至少一个A1到A9表示被至少一个从环氧基团、羟基团和氨基团中选择的基团取代的该烷基；a、b和c表示0或1；X表示具有碳-碳不饱和键的可聚合基团；Z表示从N-Y、O和S中选择的基团；Y表示H、烷基或芳基；L表示具有1到10个碳原子的二价基团。
• Sustained release compositions
  申请人：——

  公开号：US20040023987A1

  公开（公告）日：2004-02-05

  A composition prepared by containing or blending a physiologically active non-peptide substance and a biodegradable polymer having two or more carboxylic groups at its end or a salt thereof features: (1) larger content of the physiologically active non-peptide substance can be contained, as well as release of the same can be controlled or accelerated, whereby secure pharmaceutical effect is achieved; (2) when the physiologically active non-peptide substance causes subcutaneous stimulation, an activity of canceling the stimulation by strongly acidic group at its end is expected; and (3) high glass transition point and high stability.

  这是一篇有关于含有生理活性非肽物质和生物可降解聚合物的组合物的描述。该生物可降解聚合物在其末端具有两个或多个羧基或其盐，其特点是：（1）可以包含更多生理活性非肽物质，同时可以控制或加速其释放，从而实现安全的药物效果；（2）当生理活性非肽物质引起皮下刺激时，预计其末端的强酸性基团具有消除刺激的作用；（3）具有高玻璃转移温度和高稳定性。