(4-bromo-phenylimino)-phenyl-acetonitrile | 54346-50-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (4-bromo-phenylimino)-phenyl-acetonitrile
• 英文别名: (4-Brom-phenyl)-(μ-cyan-azomethin)-phenyl；(4-Brom-phenylimino)-phenylessigsaeure-nitril；(4-Brom-phenylimino)-phenyl-acetonitril；α-(p-Bromphenylimino)-phenylacetonitril；N-(4-bromophenyl)benzenecarboximidoyl cyanide
• CAS: 54346-50-8
• 化学式: C₁₄H₉BrN₂
• 分子量: 285.143
• InChiKey: CZXBJZHNQLZVAI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  17
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  36.2
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  (4-bromo-phenylimino)-phenyl-acetonitrile 在 甲醇 、 sodium hydroxide 、 silica gel 作用下， 生成 N-(4-溴苯基)苯甲酰胺
  参考文献：
  名称：

  Diarylimidoylcyanides, an Attractive Class of Intermediate: Novel Synthesis of α‐Anilino‐β‐Nitroenamines, N, N′‐ Disubstituted Amidines and Substituted Phenyl Glyoxate

  摘要：

  DOI：

  10.1080/00397910500446902
• 作为产物：
  描述：

  扁桃腈 生成 (4-bromo-phenylimino)-phenyl-acetonitrile
  参考文献：
  名称：

  LAPAROSCOPIC NEPHROURETERECTOMY FOR UPPER TRACT TRANSITIONAL CELL CANCER: THE WASHINGTON UNIVERSITY EXPERIENCE

  摘要：

  Purpose: Laparoscopic nephroureterectomy has only recently been done to treat patients with upper tract transitional cell carcinoma. We retrospectively evaluated our experience with and long-term followup of laparoscopic nephroureterectomy, compared our results to those of contemporary series of open nephroureterectomy and reviewed the literature.Materials and Methods: We reviewed the charts of and followed up by telephone 25 patients who underwent laparoscopic nephroureterectomy between May 1991 and June 1998, and 17 who underwent open nephroureterectomy between March 1990 and January 1997. Demographic, perioperative and followup data were compared. We performed a MEDLINE search and reviewed the literature on laparoscopic nephroureterectomy for upper tract transitional cell carcinoma.Results: Laparoscopic nephroureterectomy required twice the operating time of open nephroureterectomy (7.7 versus 3.9 hours). However, patients who underwent the laparoscopic procedure had a 74% decrease in analgesia requirements (37 versus 144 mg. morphine sulfate equivalent), a 63% shorter hospital stay (3.6 versus 9.6 days) and a 72% more rapid convalescence (2.8 versus 10 weeks). Subsequent bladder transitional cell carcinoma and overall cancer specific survival were similar at a mean followup of 2 years. There was no sign of trocar site or peritoneal seeding after laparoscopic nephroureterectomy.Conclusions: Although laparoscopic nephroureterectomy is a longer operation, it has the same efficacy and is better tolerated by patients than open nephroureterectomy for upper tract transitional cell carcinoma. As operating time decreases due to surgeon experience and the recent development of hand assisted laparoscopy, laparoscopic nephroureterectomy may soon become the procedure of choice for the ablative management of upper tract transitional cell carcinoma.

  DOI：

  10.1016/s0022-5347(05)67701-4

文献信息

• Rhodium(III)-Catalyzed C–H Activation of α-Iminonitriles or α-Imino Esters and Cyclization with Acrylates to 2<i>H</i>-Isoindoles
  作者：Yazhou Li、Jianhui Zhou、Feifei Fang、Bin Xu、Hong Liu、Yu Zhou

  DOI：10.1021/acs.joc.8b01664

  日期：2018.10.5

  Rh(III) catalysts have played increasingly important roles in the activation of C–H bonds to build heterocyclic scaffolds. However, there are few reports on the more challenging synthesis of pharmaceutically important 2H-isoindoles and fused 2H-isoindoles. The process reported herein is an effective strategy to produce 2H-isoindole or fused 2H-isoindole derivatives via a Rh(III)-catalyzed transformation

  Rh（III）催化剂在激活C–H键以构建杂环骨架中起着越来越重要的作用。然而，关于药学上重要的2 H-异吲哚和稠合2 H-异吲哚的更具挑战性的合成的报道很少。本文报道的方法是通过Rh（III）催化的α-亚氨基腈或α-亚氨基酯与丙烯酸酯的转化来生产2 H-异吲哚或稠合的2 H-异吲哚衍生物的有效策略。
• Barnikow; Hagen; Hagen, Pharmazie, 1983, vol. 38, # 7, p. 449 - 452
  作者：Barnikow、Hagen、Hagen、Goeres、Richter、Fichtner

  DOI：——

  日期：——
• LAPAROSCOPIC NEPHROURETERECTOMY FOR UPPER TRACT TRANSITIONAL CELL CANCER: THE WASHINGTON UNIVERSITY EXPERIENCE
  作者：ARIEH L. SHALHAV、MATTHEW D. DUNN、ANDREW J. PORTIS、ABDELHAMID M. ELBAHNASY、ELSPETH M. M c DOUGALL、RALPH V. CLAYMAN

  DOI：10.1016/s0022-5347(05)67701-4

  日期：2000.4

  Purpose: Laparoscopic nephroureterectomy has only recently been done to treat patients with upper tract transitional cell carcinoma. We retrospectively evaluated our experience with and long-term followup of laparoscopic nephroureterectomy, compared our results to those of contemporary series of open nephroureterectomy and reviewed the literature.Materials and Methods: We reviewed the charts of and followed up by telephone 25 patients who underwent laparoscopic nephroureterectomy between May 1991 and June 1998, and 17 who underwent open nephroureterectomy between March 1990 and January 1997. Demographic, perioperative and followup data were compared. We performed a MEDLINE search and reviewed the literature on laparoscopic nephroureterectomy for upper tract transitional cell carcinoma.Results: Laparoscopic nephroureterectomy required twice the operating time of open nephroureterectomy (7.7 versus 3.9 hours). However, patients who underwent the laparoscopic procedure had a 74% decrease in analgesia requirements (37 versus 144 mg. morphine sulfate equivalent), a 63% shorter hospital stay (3.6 versus 9.6 days) and a 72% more rapid convalescence (2.8 versus 10 weeks). Subsequent bladder transitional cell carcinoma and overall cancer specific survival were similar at a mean followup of 2 years. There was no sign of trocar site or peritoneal seeding after laparoscopic nephroureterectomy.Conclusions: Although laparoscopic nephroureterectomy is a longer operation, it has the same efficacy and is better tolerated by patients than open nephroureterectomy for upper tract transitional cell carcinoma. As operating time decreases due to surgeon experience and the recent development of hand assisted laparoscopy, laparoscopic nephroureterectomy may soon become the procedure of choice for the ablative management of upper tract transitional cell carcinoma.
• Diarylimidoylcyanides, an Attractive Class of Intermediate: Novel Synthesis of <i>α</i>‐Anilino‐<i>β</i>‐Nitroenamines, <i>N</i>, <i>N</i>′‐ Disubstituted Amidines and Substituted Phenyl Glyoxate
  作者：Abhijit Roychowdhury、Versha V. Kumar、A. P. Bhaduri

  DOI：10.1080/00397910500446902

  日期：2006.4.1