N-thiazol-2-yl-benzene-1,4-diamine | 845264-84-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-thiazol-2-yl-benzene-1,4-diamine
• 英文别名: 4-N-(1,3-thiazol-2-yl)benzene-1,4-diamine
• CAS: 845264-84-8
• 化学式: C₉H₉N₃S
• 分子量: 191.257
• InChiKey: MFFLBPXRTWQHAP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  13
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  79.2
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  N-thiazol-2-yl-benzene-1,4-diamine 、 4-((2-chloroquinolin-3-yl)methylene)-2-methyloxazol-5(4H)-one 在 吡啶 作用下， 生成 5-((2-chloroquinolin-3-yl)methylene)-2-methyl-3-(4-(thiazol-2-ylamino)phenyl)-3,5-dihydro-4H-imidazol-4-one
  参考文献：
  名称：

  沸石催化3'-喹啉基取代的咪唑-5-酮衍生物的高效合成及其抗菌活性

  摘要：

  通过将恶唑-5-酮，各种对位取代的苯胺和沸石在吡啶中熔融，合成了一系列新的基于喹啉的咪唑-5-酮衍生物。所有衍生物均经过了针对代表性细菌和真菌的体外抗菌筛选，其结果值得进一步研究。

  DOI：

  10.1016/j.cclet.2011.11.022
• 作为产物：
  描述：

  磺胺噻唑 在 二苯甲酮 作用下， 以 甲醇 为溶剂， 反应 50.0h， 以1.45 g的产率得到N-thiazol-2-yl-benzene-1,4-diamine
  参考文献：
  名称：

  Photooxygenation of N-(2-thiazolyl)sulfanilamide, 2-(4-thiazolyl)benzimidazole, and Thiacetazone

  摘要：

  In the present work, photolysis of N-(2-thiozolyl)sulfanilamide, 2-(4-thiazolyl)benzimidazole and thiacetazone in presence of benzophenone as a sensitizer under 125 W UV Lamp has been reported. Structures of the products have been established by spectral and elemental analysis. (doi: I 0.5562/cca1677)

  DOI：

  10.5562/cca1677

文献信息

• Compositions useful as inhibitors of voltage-gated sodium channels
  申请人：Gonzalez E. Jesus

  公开号：US20060025415A1

  公开（公告）日：2006-02-02

  The present invention relates to compounds useful as inhibitors of voltage-gated sodium channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.

  本发明涉及用作电压门控钠通道抑制剂的化合物。本发明还提供了包含本发明化合物的药学上可接受的组合物以及使用这些组合物治疗各种疾病的方法。
• 5-Substituted Thiazol-2-Yl Amino Compounds and Compositions as Protein Kinase Inhibitors
  申请人：Wan Yongqin

  公开号：US20080227783A1

  公开（公告）日：2008-09-18

  The invention provides 5-substituted thiazol-2-yl amino compounds of Formula (I): pharmaceutical compositions comprising such compounds and the use of such compounds for the treatment or prevention of diseases or disorders associated with abnormal or deregulated kinase activity, particularly diseases or disorders that involve abnormal activation of Ab 1, Aurora-A, Ber-Ab1, Bmx, CDKI/cyclinB, CHK2, Fes, FGFR3, Flt3, GSK3β, JNK1α1, Lck, MKK4 and TrkB kinases.

  本发明提供了式(I)的5-取代噻唑-2-基氨基化合物，以及包含这种化合物的制药组合物，并将这种化合物用于治疗或预防与异常或失调的激酶活性相关的疾病或障碍，特别是涉及Ab 1、Aurora-A、Ber-Ab1、Bmx、CDKI/cyclinB、CHK2、Fes、FGFR3、Flt3、GSK3β、JNK1α1、Lck、MKK4和TrkB激酶异常激活的疾病或障碍。
• Antifungal Agents
  申请人：Thomson Samantha Patricia

  公开号：US20080161302A1

  公开（公告）日：2008-07-03

  Compounds of formula (I), and pharmaceutically acceptable salts thereof, may be used in therapy, for example as antifungal agents: (I) wherein: R1, R2, R3, R4, R5, R6, R7, X and X 1 are as defined herein. Certain compounds of formula (I) are also provided. Compounds of formula (T), and agriculturally acceptable salts thereof, may also be used as agricultural fungicides.

  式(I)的化合物及其药学上可接受的盐可用于治疗，例如作为抗真菌剂：其中：R1、R2、R3、R4、R5、R6、R7、X和X1如此定义。还提供了式(I)的某些化合物。式(T)的化合物及其农业上可接受的盐也可用作农业杀菌剂。
• Compositions Useful as Inhibitors of Voltage-Gated Sodium Channels
  申请人：Gonzalez, III Jesus E.

  公开号：US20100087479A1

  公开（公告）日：2010-04-08

  The present invention relates to compounds useful as inhibitors of voltage-gated sodium channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.

  本发明涉及一种作为电压门控钠离子通道抑制剂有用的化合物。本发明还提供了包含本发明化合物的药学上可接受的组合物，并提供了使用这些组合物治疗各种疾病的方法。
• COMPOSITIONS USEFUL AS INHIBITORS OF VOLTAGE-GATED SODIUM CHANNELS
  申请人：Gonzalez, III Jesus E.

  公开号：US20120238578A1

  公开（公告）日：2012-09-20

  The present invention relates to compounds useful as inhibitors of voltage-gated sodium channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.

  本发明涉及用作电压门控钠通道抑制剂的化合物。本发明还提供了包括本发明化合物的药学上可接受的组合物以及使用这些组合物治疗各种疾病的方法。