(R)-1-(10,11-dihydro-5H-dibenzo[b,f]azepin-5-yl)-3-isopropylamino-propan-2-ol

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯氮卓类
• 英文名称: (R)-1-(10,11-dihydro-5H-dibenzo[b,f]azepin-5-yl)-3-isopropylamino-propan-2-ol
• 英文别名: (2R)-1-(5,6-dihydrobenzo[b][1]benzazepin-11-yl)-3-(propan-2-ylamino)propan-2-ol
• 化学式: C₂₀H₂₆N₂O
• 分子量: 310.439
• InChiKey: JFKKLXWNNZUBKF-GOSISDBHSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.7
• 重原子数：
  23
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  35.5
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  亚氨基二苄 在 sodium amide 作用下， 以 异丙醇 、 苯 为溶剂， 反应 8.0h， 生成 (R)-1-(10,11-dihydro-5H-dibenzo[b,f]azepin-5-yl)-3-isopropylamino-propan-2-ol
  参考文献：
  名称：

  A new class of antiarrhythmic-Defibrillatory agents

  摘要：

  Novel dibenzoazepine and 11-oxo-dibenzodiazepine derivatives area shown to be effective ventricular defibrillating drug candidates. They exhibit significant in vivo defibrillatory activity with no observed changes in ECG either before or after the VF event. These compounds also exhibit antifibrillatory activity by elevating the fibrillation threshold potential, all suggesting that such drugs could be used to treat VF either by themselves or together with electrical defibrillators. (C) 2001 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(01)00588-1

文献信息

• A new class of antiarrhythmic-Defibrillatory agents
  作者：Ofra Levy、Mordechai Erez、Dalia Varon、Ehud Keinan

  DOI：10.1016/s0960-894x(01)00588-1

  日期：2001.11

  Novel dibenzoazepine and 11-oxo-dibenzodiazepine derivatives area shown to be effective ventricular defibrillating drug candidates. They exhibit significant in vivo defibrillatory activity with no observed changes in ECG either before or after the VF event. These compounds also exhibit antifibrillatory activity by elevating the fibrillation threshold potential, all suggesting that such drugs could be used to treat VF either by themselves or together with electrical defibrillators. (C) 2001 Elsevier Science Ltd. All rights reserved.