7-(4-chlorophenyl)-3-phenylspiro[6,7-dihydro-4H-[1,3]thiazolo[4,5-d]pyrimidine-2,1'-cyclohexane]-5-thione | 1246086-94-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 7-(4-chlorophenyl)-3-phenylspiro[6,7-dihydro-4H-[1,3]thiazolo[4,5-d]pyrimidine-2,1'-cyclohexane]-5-thione
• CAS: 1246086-94-1
• 化学式: C₂₂H₂₂ClN₃S₂
• 分子量: 428.022
• InChiKey: RFHOJTMICCPOBF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.9
• 重原子数：
  28
• 可旋转键数：
  2
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.32
• 拓扑面积：
  84.7
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  7-(4-chlorophenyl)-3-phenylspiro[6,7-dihydro-4H-[1,3]thiazolo[4,5-d]pyrimidine-2,1'-cyclohexane]-5-thione 在 肼 作用下， 以 水 为溶剂， 反应 8.0h， 以65%的产率得到[7-(4-Chlorophenyl)-3-phenylspiro[4,7-dihydro-[1,3]thiazolo[4,5-d]pyrimidine-2,1'-cyclohexane]-5-yl]hydrazine
  参考文献：
  名称：

  Facile Novel Synthesis and Reactions of Thiazolidin-4-one Derivatives for Antimicrobial Agents

  摘要：

  A facile and fast procedure for synthesis of 3-phenyl-cyclohexane(1'-2)thiazolidin-4-one (1), which underwent condensation with glucose and p-chlorobenzaldehyde to afford 2 and 3, respectively. Compound 3 was used as precursor for the preparation of some fused heterocyclic compounds 4-7. Compound 4 was alkylated using dichloroacetone and chloroacetic acid to afford 8 and 9, respectively. Also, it reacted with acrylonitrile and hydrazine hydrate to afford 10 and 11, respectively. Compound 9 was condensed with p-chlorobenzaldehyde and glucose to afford 12 and 13, respectively. Selected members of the synthesized compounds were screened for antimicrobial activity.

  DOI：

  10.1080/00397910903318674
• 作为产物：
  描述：

  2-[(4-chlorophenyl)methylidene]-4-phenyl-1-thia-4-azaspiro[4.5]decan-3-one 、 硫脲 在 sodium hydroxide 作用下， 以 乙醇 为溶剂， 反应 4.0h， 以56%的产率得到7-(4-chlorophenyl)-3-phenylspiro[6,7-dihydro-4H-[1,3]thiazolo[4,5-d]pyrimidine-2,1'-cyclohexane]-5-thione
  参考文献：
  名称：

  Facile Novel Synthesis and Reactions of Thiazolidin-4-one Derivatives for Antimicrobial Agents

  摘要：

  A facile and fast procedure for synthesis of 3-phenyl-cyclohexane(1'-2)thiazolidin-4-one (1), which underwent condensation with glucose and p-chlorobenzaldehyde to afford 2 and 3, respectively. Compound 3 was used as precursor for the preparation of some fused heterocyclic compounds 4-7. Compound 4 was alkylated using dichloroacetone and chloroacetic acid to afford 8 and 9, respectively. Also, it reacted with acrylonitrile and hydrazine hydrate to afford 10 and 11, respectively. Compound 9 was condensed with p-chlorobenzaldehyde and glucose to afford 12 and 13, respectively. Selected members of the synthesized compounds were screened for antimicrobial activity.

  DOI：

  10.1080/00397910903318674

文献信息

• Facile Novel Synthesis and Reactions of Thiazolidin-4-one Derivatives for Antimicrobial Agents
  作者：Hayam H. Sayed、Eman M. H. Morsy、Eman R. Kotb

  DOI：10.1080/00397910903318674

  日期：2010.8.16

  A facile and fast procedure for synthesis of 3-phenyl-cyclohexane(1'-2)thiazolidin-4-one (1), which underwent condensation with glucose and p-chlorobenzaldehyde to afford 2 and 3, respectively. Compound 3 was used as precursor for the preparation of some fused heterocyclic compounds 4-7. Compound 4 was alkylated using dichloroacetone and chloroacetic acid to afford 8 and 9, respectively. Also, it reacted with acrylonitrile and hydrazine hydrate to afford 10 and 11, respectively. Compound 9 was condensed with p-chlorobenzaldehyde and glucose to afford 12 and 13, respectively. Selected members of the synthesized compounds were screened for antimicrobial activity.