(2,2-dimethyl-1,3-dioxolan-4-yl)methyl 4-hydroxybenzoate | 141969-75-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (2,2-dimethyl-1,3-dioxolan-4-yl)methyl 4-hydroxybenzoate
• 英文别名: 4-hydroxy-benzoic acid-(2,2-dimethyl-[1,3]dioxolan-4-ylmethyl ester)；4-Hydroxy-benzoesaeure-(2,2-dimethyl-[1,3]dioxolan-4-ylmethylester)
• CAS: 141969-75-7
• 化学式: C₁₃H₁₆O₅
• 分子量: 252.267
• InChiKey: IUSABAVRYBELBB-UHFFFAOYSA-N

物化性质

• 沸点：
  377.4±22.0 °C(Predicted)
• 密度：
  1.195±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  18
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.46
• 拓扑面积：
  65
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  (2,2-dimethyl-1,3-dioxolan-4-yl)methyl 4-hydroxybenzoate 、 布洛芬 在 双(2-氧代-3-恶唑烷基)次磷酰氯 、 三乙胺 作用下， 以 二氯甲烷 为溶剂， 反应 16.0h， 以75%的产率得到(2,2-dimethyl-1,3-dioxolan-4-yl)methyl 4-((2-(4-isobutylphenyl)propanoyl)oxy)benzoate
  参考文献：
  名称：

  [EN] POLYMER-NSAID CONJUGATE
  [FR] CONJUGUÉ POLYMÈRE-AINS

  摘要：

  该发明涉及用于传递替代烷基酸非甾体抗炎药物（NSAID）的聚合物-药物共轭物。该发明还涉及包括聚合物-NSAID共轭物的药物传递系统。聚合物-NSAID共轭物包括通过酯键连接到可生物降解聚合物骨架的替代烷基酸非甾体抗炎药物（NSAID）。

  公开号：

  WO2014000033A1
• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 在 sodium hydroxide 作用下， 生成 (2,2-dimethyl-1,3-dioxolan-4-yl)methyl 4-hydroxybenzoate
  参考文献：
  名称：

  Wilkinson et al., Biochemical Journal, 1953, vol. 54, p. 16,18

  摘要：

  DOI：

文献信息

• POLYMER-NSAID CONJUGATE
  申请人：POLYACTIVA PTY LTD

  公开号：US20150150999A1

  公开（公告）日：2015-06-04

  The invention relates to polymer-drug conjugate for delivering a substituted alkanoic acid non-steroidal anti-inflammatory drug (NSAID). The invention also relates to drug delivery systems comprising the polymer-NSAID conjugate. The polymer-NSAID conjugates comprise a substituted alkanoic acid non-steroidal anti-inflammatory drug (NSAID) conjugated to a biodegradable polymer backbone by an ester linkage.

  本发明涉及聚合物-药物共轭物，用于传递一种取代的烷基酸非甾体抗炎药（NSAID）。本发明还涉及包括聚合物-NSAID共轭物的药物传递系统。聚合物-NSAID共轭物由一种取代的烷基酸非甾体抗炎药（NSAID）通过酯键连接到可生物降解的聚合物骨架上组成。
• A case controlled study of laparoscopic incisional hernia repair
  作者：R. Chari、V. Chari、M. Eisenstat、R. Chung

  DOI：10.1007/s004649900079

  日期：2000.2

  Background: Although the feasibility of laparoscopic incisional herniorrhaphy has been demonstrated, its advantages over the open technique are still unproven,Methods: Fourteen consecutive laparoscopic incisional hernia repairs were compared with 14 matched controls of the open repair done by the same surgeon at the same institution. The controls were selected by a medical record technician not connected with the study, The cases were selected to match diagnoses, ASA status, and body weight as closely as possible. The outcome data for operating time, blood loss, hospitalization, resumption of oral intake, and postoperative complications were analyzed for statistically significant differences.Results: There was no statistical difference between the two groups in the parameters of blood loss, hospital days, or days to oral intake, The laparoscopic operation took 40% longer. Similar complications were seen in both groups. No mortality or early recurrences occurred in either group.Conclusion: Laparoscopic incisional hernia repair of at least moderate complexity had no demonstrable advantage over the open repair in the present study.
• US5153353A
  申请人：——

  公开号：US5153353A

  公开（公告）日：1992-10-06
• US9968684B2
  申请人：——

  公开号：US9968684B2

  公开（公告）日：2018-05-15
• [EN] POLYMER-NSAID CONJUGATE<br/>[FR] CONJUGUÉ POLYMÈRE-AINS
  申请人：POLYACTIVA PTY LTD

  公开号：WO2014000033A1

  公开（公告）日：2014-01-03

  The invention relates to polymer-drug conjugate for delivering a substituted alkanoic acid non-steroidal anti-inflammatory drug (NSAID). The invention also relates to drug delivery systems comprising the polymer-NSAID conjugate. The polymer-NSAID conjugates comprise a substituted alkanoic acid non-steroidal anti-inflammatory drug (NSAID) conjugated to a biodegradable polymer backbone by an ester linkage.

  该发明涉及用于传递替代烷基酸非甾体抗炎药物（NSAID）的聚合物-药物共轭物。该发明还涉及包括聚合物-NSAID共轭物的药物传递系统。聚合物-NSAID共轭物包括通过酯键连接到可生物降解聚合物骨架的替代烷基酸非甾体抗炎药物（NSAID）。