2,7-二氟芴-9-酮 | 24313-53-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 芴
• 中文名称: 2,7-二氟芴-9-酮
• 中文别名: 2,7-二氟-9H-芴-9-酮
• 英文名称: 2,7-difluoro-9-fluorenone
• 英文别名: 2,7-difluorofluoren-9-one；2,7-Difluor-fluorenon
• CAS: 24313-53-9
• 化学式: C₁₃H₆F₂O
• mdl: MFCD00032925
• 分子量: 216.187
• InChiKey: VEOGWHFDYPRACH-UHFFFAOYSA-N

物化性质

• 熔点：
  208-210 °C
• 沸点：
  353.7±35.0 °C(Predicted)
• 密度：
  1.410±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  16
• 可旋转键数：
  0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  3

安全信息

• 海关编码：
  2914700090
• 储存条件：
  2-8°C

反应信息

• 作为反应物：
  描述：

  2,7-二氟芴-9-酮 生成 咪瑞司他
  参考文献：
  名称：

  [EN] METHOD OF INHIBITING ALDOSE REDUCTASE ACTIVITY, COMPOSITIONS THEREFOR AND PROCESS FOR PREPARING SPIRO-FLUOROFLUOREN AND SPIRO-DIFLUOROFLUOREN COMPOUNDS

  摘要：

  (中文) 糖尿病患者中的多元醇积累导致或与糖尿病并发症有关。醛固酮还原酶抑制剂可以防止多元醇的产生。四环螺噻嗪可以抑制醛固酮还原酶活性，因此这些化合物在治疗糖尿病并发症方面非常有用。本文还介绍了一种制备四环螺噻嗪的方法，即通过将单氟芴或二氟芴与过量的氧和四烷基或芳基烷基三烷基铵氢氧化物反应，然后在高温下将反应产物与碳酸铵和氰化钾环化。

  公开号：

  WO1983003543A1
• 作为产物：
  描述：

  2,7-二氨基-9-芴酮 在 吡啶 、 氢氟酸 、 sodium nitrite 作用下， 以62%的产率得到2,7-二氟芴-9-酮
  参考文献：
  名称：

  Dications of Fluorenylidenes. Electronic Effects on the Paratropicity/Antiaromaticity of 2,7-Disubstituted Fluorenyl Cations

  摘要：

  Oxidation of 2,7-disubstituted tetrabenzo[5.5]fulvalene derivatives 1a-d resulted in the formation of dications which are fluorenyl cations linked by a single bond. These fluorenyl cations exhibit significant paratropicity in the H-1 NMR spectrum, which is attributed to an antiaromatic ring current. Interaction of the perpendicular ring systems is evident in the upfield shift of carbons a and a', presumably due to sigma-p donation. The lack of variation in the upfield shift of carbons a and a', compared to previously reported systems, is attributed to the similarities of the geometries of 1a-d(2+). Substitution at a remote site affects the antiaromaticity of the unsubstituted fluorenyl cation, but the nature of the effect of the substituent is not understood. Direct substitution on the fluorenyl cation by substituents which increase electron density, either through inductive It polarization or through resonance, cause a paratropic shift in the probe proton.

  DOI：

  10.1021/jo972202s

文献信息

• [EN] TRICYCLIC COMPOUNDS<br/>[FR] COMPOSÉS TRICYCLIQUES
  申请人：VIVACE THERAPEUTICS INC

  公开号：WO2017058716A1

  公开（公告）日：2017-04-06

  Provided herein are compounds and pharmaceutical compositions comprising said compounds that are useful for treating cancers or congenital diseases. Specific cancers and congenital disease includes those that are mediated by YAP/TAZ.

  本文提供了包含所述化合物的药物组合物，用于治疗癌症或先天性疾病。具体的癌症和先天性疾病包括那些由YAP/TAZ介导的疾病。
• Cross Dehydrogenative Coupling via Base-Promoted Homolytic Aromatic Substitution (BHAS): Synthesis of Fluorenones and Xanthones
  作者：Sebastian Wertz、Dirk Leifert、Armido Studer

  DOI：10.1021/ol4000857

  日期：2013.2.15

  Cross dehydrogenative coupling reactions occurring via base-promoted homolytic aromatic substitutions (BHASs) are reported. Fluorenones and xanthones are readily prepared via CDC starting with readily available ortho-formyl biphenyls and ortho-formyl biphenylethers, respectively. The commercially available and cheap tBuOOH is used as an oxidant. Initiation of the radical chain reaction is best achieved

  报道了通过碱促进的均相芳族取代（BHAS）发生的交叉脱氢偶联反应。可以通过CDC容易地分别从容易获得的邻甲酰基联苯和邻甲酰基联苯醚开始制备芴酮和氧杂蒽。市售和廉价的t BuOOH被用作氧化剂。用少量的FeCp 2（0.1或1 mol％）可以最好地实现自由基链反应的引发。
• Synthesis of fluorenones viaquaternary ammonium salt-promoted intramolecular dehydrogenative arylation of aldehydes
  作者：Zhuangzhi Shi、Frank Glorius

  DOI：10.1039/c2sc21823b

  日期：——

  Biologically interesting fluorenone, xanthone and anthrone derivatives have been prepared via an intramolecular oxidative acylation process. This novel direct acylation reaction proceeded without the aid of any transition metals, acids or bases, and uses a catalytic amount of a quaternary ammonium salt in the presence of a persulfate oxidant. Initial mechanistic studies have been carried out to elucidate

  生物有趣 芴酮， 黄酮蒽酮衍生物是通过分子内氧化酰化方法制备的。这种新颖的直接酰化反应无需任何过渡金属，酸或碱即可进行，并在过硫酸盐氧化剂存在下使用催化量的季铵盐。已经进行了初步的机理研究以阐明反应途径。
• Method of inhibiting aldose reductase activity
  申请人：Alcon Laboratories, Inc.

  公开号：US04436745A1

  公开（公告）日：1984-03-13

  Inhibition of aldose reductase activity with tetracyclic spiro-hydantoins.

  使用四环螺环垂直二酮抑制醛糖还原酶活性。
• Treatment of diabetic complications with certain
  申请人：Alcon Laboratories, Inc.

  公开号：US04540700A1

  公开（公告）日：1985-09-10

  Inhibition of aldose reductase activity with tetracyclic spiro-hydantoins, new tetracyclic spirohydantoin derivatives useful in the treatment of complications arising from diabetes mellitus, and a process for preparing spiro-imidazolidine-diones by reacting a mono- or di-fluorofluorene with an excess of oxygen and a tetralkyl- or arylalkyl-trialkyl-ammonium hydroxide are disclosed.

  使用四环螺环噁唑烷酮抑制醛糖还原酶活性，新的四环螺环噁唑烷酮衍生物可用于治疗糖尿病引起的并发症，以及通过将单氟或双氟芴与氧气过量和四烷基或芳基烷基三烷基铵氢氧化物反应来制备螺咪唑烷二酮的方法被披露。