2-(α-chlorophenylmethyl)biphenyl | 30469-78-4

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二芳基庚烷
• 英文名称: 2-(α-chlorophenylmethyl)biphenyl
• 英文别名: o-Phenylbenzhydrylchlorid；α-biphenylyl-benzyl chloride；alpha-Biphenylyl-benzyl chloride；1-[chloro(phenyl)methyl]-2-phenylbenzene
• CAS: 30469-78-4
• 化学式: C₁₉H₁₅Cl
• 分子量: 278.781
• InChiKey: DABZVHXWMGLANW-UHFFFAOYSA-N

物化性质

• 沸点：
  423.3±24.0 °C(Predicted)
• 密度：
  1.132±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  5.6
• 重原子数：
  20
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.05
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  0

反应信息

• 作为反应物：
  描述：

  2-(α-chlorophenylmethyl)biphenyl 在 甲醇 作用下， 生成 2-(α-methoxyphenylmethyl)biphenyl
  参考文献：
  名称：

  Metanolysis of phenyl-substituted benzhydryl chlorides

  摘要：

  DOI：

  10.1021/jo00817a038
• 作为产物：
  描述：

  二氢-3-(异十二碳烯基)呋喃-2,5-二酮 在 lithium aluminium tetrahydride 、 五氯化磷 作用下， 以 乙醚 为溶剂， 反应 2.0h， 生成 2-(α-chlorophenylmethyl)biphenyl
  参考文献：
  名称：

  Intramolecular reactivity of arylcarbenes: Biphenyl-2-ylcarbenes

  摘要：

  Biphenyl-2-ylcarbenes, 2-ArC(6)H(4)CR, were generated photolytically and thermally from diazo precursors. Cyclization, leading to fluorenes, competes with capture of the carbenes by methanol but proceeds faster than intramolecular hydrogen shifts (with R = Me) and intermolecular C-H insertion reactions (with R = H in cyclohexane). By comparison of product ratios with kinetic data for related carbenes from the literature, the cyclization rate is estimated as ca 10(11) s(-1). The intramolecular reactivity of biphenyl-2-ylcarbenes is nor significantly attenuated by variation of R (R = H, Me, Ph). Very minor effects of triplet sensitization and methanol quenching indicate that fluorenes arise from spin-equilibrated biphenyl-2-ylcarbenes, presumably from the singlet state. When Ar = mesityl, the carbene predominantly inserts into C-H bonds of the 2'-methyl groups, giving rise to a dihydrophenanthrene. Formation of a fluorene derivative, by formal insertion into C-C bonds, occurs as a minor process. This unprecedented reaction points to intervention of an o-xylylene in which the methyl group migrates. Laser flash photolysis (LFP) of 2-PhC(6)H(4)CN(2)Ph generates a transient absorption which is due to the T-0-->T-n transition of 9-phenylfluorene rather than to the presumed o-xylylene. On LFP of 2-ArC(6)H(4)CN(2)Ph in trifluoroethanol-acetonitrile, protonation of the carbenes gives rise to carbocations, 2-ArC(6)H(4)CH(+)Ph. The transient absorption spectra of these cations are strongly influenced by twisting about the Ar-Ar bond (Ar = Ph < o-tolyl < mesityl) whereas the rates of nucleophilic capture vary only slightly. Biphenyl-2-ylcarbenium ions (Ar = R = Ph) cyclize more slowly than the analogous carbenes, by a factor of greater than or equal to 10(4).

  DOI：

  10.1002/(sici)1099-1395(199609)9:9<598::aid-poc825>3.0.co;2-l

文献信息

• .alpha.-(4-Biphenylyl)-benzyl-azolium salts and their use for combating
  申请人：Bayer Aktiengesellschaft

  公开号：US04243670A1

  公开（公告）日：1981-01-06

  The present invention relates to novel .alpha.-(4-biphenylyl)-benzyl-azolium salts of the general formula ##STR1## in which A represents the CH group or a N atom R.sup.1 and R.sup.2 are identical or different and each represents hydrogen, alkyl or optionally substituted phenyl, R.sup.3 represents hydrogen, alkyl, or an optionally substituted phenyl, phenylalkyl, phenylcarbonyl or phenylcarbonylalkyl group, X represents halogen, alkyl, halogenoalkyl, alkoxy, alkylthio, nitro or cyano, Y represents X or optionally substituted phenyl, m and n each represents 0 or an integer from1 to 5 and Z represents the anion of an inorganic or organic acid. The invention also includes processes for the preparation of the compounds and, in addition includes compositions containing the compounds and methods for their use. The compounds of the invention exhibit antimicrobial activity and sporicidal activity.

  本发明涉及新的 α-(4-联苯基)-苄基-氮杂环盐，其通式为 ##STR1## 其中，A代表CH基团或N原子，R1和R2相同或不同，分别代表氢、烷基或可选取代的苯基，R3代表氢、烷基或可选取代的苯基、苯基烷基、苯基羰基或苯基羰基烷基，X代表卤素、烷基、卤代烷基、烷氧基、烷硫基、硝基或氰基，Y代表X或可选取代的苯基，m和n分别代表0或1至5的整数，Z代表无机或有机酸的阴离子。本发明还包括制备该化合物的方法，以及含有该化合物的组合物和使用方法。本发明的化合物具有抗微生物活性和杀孢活性。
• Combating crop damaging fungi with .alpha.-(4-biphenylyl)-benzyl-azolium
  申请人：Bayer Aktiengesellschaft

  公开号：US04251540A1

  公开（公告）日：1981-02-17

  .alpha.-(4-Biphenylyl)-benzyl-azolium salts of the formula ##STR1## in which A is CH or N, R.sup.1 and R.sup.2 each independently is hydrogen, alkyl or optionally substituted phenyl, R.sup.3 is hydrogen, alkyl or optionally substituted phenyl, phenylalkyl, phenylcarbonyl or phenylcarbonylalkyl, m is 0, 1, 2, 3, 4 or 5, X each independently is halogen, alkyl, halogenoalkyl, alkoxy, alkylthio, nitro or cyano, n is 0, 1, 2, 3, 4 or 5, Y each independently is halogen, alkyl, halogenoalkyl, alkoxy, alkylthio, nitro, cyano or phenyl which is optionally substituted by halogen, alkyl, halogenoalkyl, alkoxy, alkylthio, nitro or cyano, and Z is the anion of an inorganic or organic acid, are used to combat fungi.

  .alpha.-(4-联苯基)-苄基-咪唑盐的化学式为##STR1##，其中A为CH或N，R.sup.1和R.sup.2各自独立地为氢、烷基或可选取代的苯基，R.sup.3为氢、烷基或可选取代的苯基、苯基烷基、苯基羰基或苯基羰基烷基，m为0、1、2、3、4或5，X各自独立地为卤素、烷基、卤代烷基、烷氧基、烷硫基、硝基或氰基，n为0、1、2、3、4或5，Y各自独立地为卤素、烷基、卤代烷基、烷氧基、烷硫基、硝基、氰基或苯基，该苯基可选取代的卤素、烷基、卤代烷基、烷氧基、烷硫基、硝基或氰基，Z为无机或有机酸的阴离子，可用于抗真菌。
• Synthesis procedure for biphenylimidazolyl-(1)-phenylmethane and related compounds
  申请人：MANUFACTURAS HUMBERTO TO BUELE HIJOS, S.

  公开号：US20040267027A1

  公开（公告）日：2004-12-30

  A synthesis procedure for the manufacture of byphenylimidazolyl-(1)-phenylmethane involves the reduction of 4-phenyl-benzophenone and subsequent reaction of biphenyl-phenyl-carbinol with imidazole. In a preferred form, there are two synthesis steps, the first step being the reduction of 4-phenyl-benzophenone to biphenyl-phenyl-carbinol being with sodium borohydride in the presence of alumina, and the second step being the reaction between biphenyl-phenyl-carbinol and imidazole assisted by microwaves, in the absence of any organic or inorganic solvents, obtaining a yield between 70 to 74% of pure product in a total reaction time of no more than three hours.

  一种制备双苯基咪唑基-(1)-苯甲烷的合成方法包括将4-苯基苯并酮还原，然后将联苯苯甲醇与咪唑反应。在首选形式中，有两个合成步骤，第一步是将4-苯基苯并酮还原为联苯苯甲醇，使用硼氢化钠在氧化铝的存在下进行，第二步是在微波辅助下，在没有任何有机或无机溶剂的情况下，将联苯苯甲醇和咪唑反应，总反应时间不超过三小时，在产率为70％至74％的纯产品。
• ZERBES, R.;REGEL, E.;PLEMPEL, M.
  作者：ZERBES, R.、REGEL, E.、PLEMPEL, M.

  DOI：——

  日期：——
• US4118487A
  申请人：——

  公开号：US4118487A

  公开（公告）日：1978-10-03