benzyl (coumarin-3-yl)carbamate

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 香豆素及其衍生物
• 英文名称: benzyl (coumarin-3-yl)carbamate
• 英文别名: benzyl N-(2-oxochromen-3-yl)carbamate
• 化学式: C₁₇H₁₃NO₄
• 分子量: 295.295
• InChiKey: NKZOGSNXAOKDMO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  22
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  64.6
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  3-氨基香豆素 、 氯甲酸苄酯 在 吡啶 作用下， 以 二氯甲烷 为溶剂， 反应 3.0h， 以80%的产率得到benzyl (coumarin-3-yl)carbamate
  参考文献：
  名称：

  Novel (coumarin-3-yl)carbamates as selective MAO-B inhibitors: Synthesis, in vitro and in vivo assays, theoretical evaluation of ADME properties and docking study

  摘要：

  A series of (coumarin-3-yl)carbamates was synthesized and evaluated in vitro as monoamine oxidase (MAO-A and MAO-B) inhibitors. Most of the new compounds selectively inhibited MAO-B isoenzyme with IC50 values in the micro or nanoMolar ranges. Since these compounds must achieve the brain cells, theoretical evaluation of ADME properties were also carried out. Compound 8 (benzyl(coumarin-3yl)carbamate), which presented the most interesting in vitro MAO-B inhibitory profile (IC50 against MAO-B = 45 nM), was subjected to further studies. This in vitro MAO-B inhibitory activity is comparable with that of the selegiline, the reference compound (IC50 against MAO-B = 20 nM). Taking into account the in vitro results of compound 8, in vivo assays and docking calculations were also carried out for this derivative. (C) 2013 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2013.02.009

文献信息

• A convenient and expeditious synthesis of 3-(N-substituted) aminocoumarins via palladium-catalyzed Buchwald–Hartwig coupling reaction
  作者：Davide Audisio、Samir Messaoudi、Jean-François Peyrat、Jean-Daniel Brion、Mouâd Alami

  DOI：10.1016/j.tetlet.2007.07.166

  日期：2007.9

  A convenient protocol for the rapid and efficient synthesis of 3-(N-substituted) aminocoumarins is described. The synthetic route developed involves the Pd-catalyzed C–N coupling reaction from readily available 3-bromocoumarin derivatives in the presence of the catalytic system Pd(OAc)2/Xantphos. Under these conditions, a series of nucleophiles including amides, sulfonamides, carbamates and functionalized

  描述了一种快速有效合成3-（N-取代）氨基香豆素的简便方法。所开发的合成路线涉及在催化体系Pd（OAc）2 / Xantphos存在下，由容易获得的3-溴香豆素衍生物进行Pd催化的C–N偶联反应。在这些条件下，包括酰胺，磺酰胺，氨基甲酸酯和官能化胺在内的一系列亲核试剂已成功反应，以公平的收率获得了良好的偶联产物。
• Novel (coumarin-3-yl)carbamates as selective MAO-B inhibitors: Synthesis, in vitro and in vivo assays, theoretical evaluation of ADME properties and docking study
  作者：Maria J. Matos、Santiago Vilar、Rosa Mª Gonzalez-Franco、Eugenio Uriarte、Lourdes Santana、Carol Friedman、Nicholas P. Tatonetti、Dolores Viña、Jose A. Fontenla

  DOI：10.1016/j.ejmech.2013.02.009

  日期：2013.5

  A series of (coumarin-3-yl)carbamates was synthesized and evaluated in vitro as monoamine oxidase (MAO-A and MAO-B) inhibitors. Most of the new compounds selectively inhibited MAO-B isoenzyme with IC50 values in the micro or nanoMolar ranges. Since these compounds must achieve the brain cells, theoretical evaluation of ADME properties were also carried out. Compound 8 (benzyl(coumarin-3yl)carbamate), which presented the most interesting in vitro MAO-B inhibitory profile (IC50 against MAO-B = 45 nM), was subjected to further studies. This in vitro MAO-B inhibitory activity is comparable with that of the selegiline, the reference compound (IC50 against MAO-B = 20 nM). Taking into account the in vitro results of compound 8, in vivo assays and docking calculations were also carried out for this derivative. (C) 2013 Elsevier Masson SAS. All rights reserved.