The present invention is broadly directed to azole derivatives that exhibit antifungal activity and methods for making the same. In one aspect, the invention includes carboxylic acid and phosphate ester derivatives of fluconazole that exhibit antifungal activity. In addition, the invention comprises methods for synthesizing the derivatives and pharmaceutical compositions containing the derivatives.
本发明广泛涉及具有抗真菌活性的唑衍
生物及其制造方法。在一个方面,本发明包括具有抗真菌活性的
氟康唑的
羧酸和
磷酸酯衍
生物。此外,本发明还包括合成这些衍
生物和含有这些衍
生物的药物组合物的方法。