14-((4-nitrophenyl)methylene)matrine | 1253691-67-6

• 分子结构分类: 有机化合物 - 生物碱及其衍生物 - 羽扇豆生物碱
• 英文名称: 14-((4-nitrophenyl)methylene)matrine
• CAS: 1253691-67-6
• 化学式: C₂₂H₂₇N₃O₃
• 分子量: 381.475
• InChiKey: FCICRDFMAZEDKP-KCLUMXDGSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.47
• 重原子数：
  28.0
• 可旋转键数：
  2.0
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.59
• 拓扑面积：
  66.69
• 氢给体数：
  0.0
• 氢受体数：
  4.0

反应信息

• 作为产物：
  描述：

  对硝基苯甲醛 、 苦参碱 在 sodium hydride 作用下， 以 四氢呋喃 为溶剂， 反应 8.0h， 以28%的产率得到14-((4-nitrophenyl)methylene)matrine
  参考文献：
  名称：

  Synthesis, characterization and in vitro anti-tumor activities of matrine derivatives

  摘要：

  Nineteen previously unreported matrine derivatives were synthesized and characterized using elemental analysis, infrared spectroscopy, proton nuclear magnetic resonance spectroscopy, and mass spectrometry. Target compounds 6a-6l and 7a-7c showed stronger inhibitory activities than matrine in the in vitro antitumor tests and inhibited the growth of the Hep7402, B16-F10, A549, and TW03 cell lines. In addition, compound 6i exhibited a potent antitumor activity similar to that of colchicine. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2012.04.069

文献信息

• Synthesis, characterization and in vitro anti-tumor activities of matrine derivatives
  作者：Lisheng Wang、Yejun You、Songqing Wang、Xu Liu、Buming Liu、Jinni Wang、Xiao Lin、Mingsheng Chen、Gang Liang、Hua Yang

  DOI：10.1016/j.bmcl.2012.04.069

  日期：2012.6

  Nineteen previously unreported matrine derivatives were synthesized and characterized using elemental analysis, infrared spectroscopy, proton nuclear magnetic resonance spectroscopy, and mass spectrometry. Target compounds 6a-6l and 7a-7c showed stronger inhibitory activities than matrine in the in vitro antitumor tests and inhibited the growth of the Hep7402, B16-F10, A549, and TW03 cell lines. In addition, compound 6i exhibited a potent antitumor activity similar to that of colchicine. (C) 2012 Elsevier Ltd. All rights reserved.