1,2-Dithia-5,8,11,14,17-pentaoxacyclononadecane | 89141-23-1

• 分子结构分类: 有机化合物 - 有机硫化合物 - 有机二硫化物
• 英文名称: 1,2-Dithia-5,8,11,14,17-pentaoxacyclononadecane
• 英文别名: dithio-18-crown-6；1,8,11,14,17-Pentaoxa-4,5-dithiacyclononadecane
• CAS: 89141-23-1
• 化学式: C₁₂H₂₄O₅S₂
• 分子量: 312.452
• InChiKey: NQLKANNQXQXAGE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.1
• 重原子数：
  19
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  96.8
• 氢给体数：
  0
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  六甘醇 在 copper(l) chloride N,N'-二环己基碳二亚胺 、 benzyltriethylammonium tetrathiomolybdate 作用下， 以 乙腈 为溶剂， 以40%的产率得到1,2-Dithia-5,8,11,14,17-pentaoxacyclononadecane
  参考文献：
  名称：

  一锅法将四硫代钼酸苄基三乙铵介导的醇转化为二硫化物

  摘要：

  据报道，通过用DCC或P（NMe 2）3 / CCl 4活化羟基，然后用苄基三乙基四硫代钼酸铵处理，将醇一锅转化为高产率的二硫化物。

  DOI：

  10.1016/s0040-4020(99)00939-4

文献信息

• Reduction of sulfur with borohydride exchange resin in methanol: application to rapid and selective synthesis of disulfides
  作者：B.P Bandgar、L.S Uppalla、V.S Sadavarte

  DOI：10.1016/s0040-4039(01)00789-4

  日期：2001.9

  A convenient and rapid method for the synthesis of symmetrical disulfides from alkyl or aryl alkyl halides using sulfurated borohydride exchange resin (SBER) under anhydrous conditions is described. Selective transfer of sulfur to an alkyl group rather than an aryl group is achieved using this methodology.

  描述了一种在无水条件下使用硫化硼氢化物交换树脂（SBER）从烷基或芳基烷基卤化物合成对称二硫化物的便捷方法。使用这种方法可以实现硫选择性地转移到烷基而不是芳基上。
• Formulations comprising cyclic compounds
  申请人：Botti, Paolo

  公开号：EP1905454A1

  公开（公告）日：2008-04-02

  This invention relates to the use of a cyclic compound of formula (I) wherein A, B independently in each occurrence is alkane-i,j-diyl having k carbon atoms, i and independently j being less than or equal k and k being selected from 1 to 10, wherein said alkane-i,j-diyl (i) may comprise one or more double bonds; (ii) is optionally substituted; and/or (iii) comprises a cycle, wherein the total number of cycles being cyclic sugars in said compound is selected from 0 to 4 and is less than p-(n+m); X,Y independently in each occurrence is a biocompatible functional group comprising at least one oxygen atom or two sulphur atoms; n, m independently of each other are selected from 0 to 20; p is selected from 1 to 10; n+m is equal or greater than 1; and p-(n+m) is selected from 3 to 30; wherein said compound is capable of forming a complex with a protonated primary and/or protonated secondary amino group and/or a protonated guanidinium group for the manufacture of a pharmaceutical or diagnostic composition further comprising a pharmaceutically or diagnostically active agent, said active agent comprising one or more protonated primary and/or protonated secondary amino groups and/or a protonated guanidinium groups, wherein (a) transmembrane and/or transmucosal delivery; (b) solubility in non-aqueous solvents; and/or (c) stability of said active agent are improved.

  本发明涉及使用公式（I）的环状化合物，其中A，B分别在每次出现时为具有k个碳原子的烷基-i，j-二基，i和j分别独立于k，k选择从1到10，其中所述烷基-i，j-二基（i）可以包括一个或多个双键；（ii）可选地被取代；和/或（iii）包括一个环，其中所述化合物中的环状糖的总数选择从0到4，并且小于p-（n+m）；X，Y分别在每次出现时是至少包含一个氧原子或两个硫原子的生物相容性功能基团；n，m彼此独立地选择从0到20；p选择从1到10；n+m等于1或更大；p-（n+m）选择从3到30；其中所述化合物能够与质子化的一级和/或质子化的二级氨基基团和/或质子化的鸟氨酸基团形成复合物，用于制造制药或诊断组合物，进一步包括药物学或诊断学活性剂，所述活性剂包括一个或多个质子化的一级和/或质子化的二级氨基基团和/或质子化的鸟氨酸基团，其中（a）跨膜和/或经黏膜递送；（b）在非水溶剂中的溶解度；和/或（c）所述活性剂的稳定性得到改善。
• A facile entry to macrocyclic disulfides: an efficient synthesis of redox-switched crown ethers
  作者：A. R. Ramesha、Srinivasan Chandrasekaran

  DOI：10.1021/jo00085a025

  日期：1994.3

  An interesting sulfur transfer reaction with benzyltriethylammonium tetrathiomolybdate has been used efficiently for the synthesis of macrocyclic disulfides. This methodology has been extended to a high-yield synthesis of ''redox-switched'' crown ethers which have potential application for selective ion transport across liquid membranes.
• Ramesha A. R., Chandrasekaran Srinivasan, J. Org. Chem, 59 (1994) N 6, S 1354-1357
  作者：Ramesha A. R., Chandrasekaran Srinivasan

  DOI：——

  日期：——
• RABAN, M.;GREENBLATT, J.;KANDIL, F., J. CHEM. SOC. CHEM. COMMUN., 1983, N 23, 1409-1411
  作者：RABAN, M.、GREENBLATT, J.、KANDIL, F.

  DOI：——

  日期：——