dibromo(bistriphenylphosphine) palladium

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: dibromo(bistriphenylphosphine) palladium
• 英文别名: dibromobis(triphenylphosphine) palladium；dibromobistriphenylphosphine palladium；dibromobistriphenylphosphinepalladium；dibromopalladium;triphenylphosphane
• 化学式: Br₂Pd*2C₁₈H₁₅P
• 分子量: 790.81
• InChiKey: YFSFDFFPECZXJR-UHFFFAOYSA-L

计算性质

• 辛醇/水分配系数(LogP)：
  5.13
• 重原子数：
  22
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  0

反应信息

• 作为反应物：
  描述：

  dibromo(bistriphenylphosphine) palladium 、 正丁醇 在 三正丁胺 作用下， 以 4-溴苯腈 为溶剂， 以89%的产率得到butyl 4-cyanobenzoate
  参考文献：
  名称：

  Process for the preparation of carboxylic acid esters from organic

  摘要：

  羧酸酯或酰胺可由芳基、杂环、烯基、乙炔基和苄基卤化物及其取代物与醇或一级或二级胺以及一氧化碳在钯催化剂存在下反应而得，必要时在大约20-150摄氏度和大约半个大气压至100大气压下进行。一个典型的例子是在100摄氏度和一个大气压的一氧化碳存在下，将溴苯转化为正丁基苯甲酸酯，同时存在三正丁基胺和PdBr.sub.2[P(C.sub.6 H.sub.5).sub.3].sub.2的催化剂量。

  公开号：

  US03988358A1

文献信息

• 2,3,5-trisubstituted pyridines as inhibitors of cyclooxygenase-2
  申请人：Merck Frosst Canada & Co.

  公开号：US06046217A1

  公开（公告）日：2000-04-04

  The invention encompasses the novel compound of Formula I as well as a method of treating cyclooxygenase-2 mediated diseases comprising administration to a patient in need of such treatment of a non-toxic therapeutically effective amount of a compound of Formula I. ##STR1## The invention also encompasses certain pharmaceutical compositions for treatment of cyclooxygenase-2 mediated diseases comprising compounds of Formula I.

  该发明涵盖了公式I的新化合物，以及一种治疗环氧合酶-2介导疾病的方法，包括向需要该治疗的患者施用公式I化合物的非毒性治疗有效量。 该发明还涵盖了用于治疗环氧合酶-2介导疾病的特定药物组合，包括公式I的化合物。
• Pyrimido[4,5-d][2]benzazepines
  申请人：Hoffmann-La Roche Inc.

  公开号：US04427589A1

  公开（公告）日：1984-01-24

  There is presented a compound of the formula ##STR1## wherein R.sub.1 is selected from the group consisting of hydrogen, lower alkyl, chloro, bromo, alkoxy, hydroxy, lower alkyl substituted thio and NR.sub.4 R.sub.5 wherein R.sub.4 and R.sub.5 are hydrogen, lower alkyl and di-substituted lower alkylamino lower alkyl; R.sub.2 is selected from the group consisting of hydrogen, lower alkyl and amino; R.sub.3 is selected from the group consisting of hydrogen, acyloxy and hydroxy; X is halogen and Y is hydrogen or halogen and the N-oxides thereof when R.sub.3 is hydrogen and the pharmaceutically acceptable salts thereof. The pyrimido[4,5-d][2]benzazepines are useful as anxiolytic and sedative agents. Also presented are processes and intermediates in the production of the above pyrimido[4,5-d][2]benzazepines.

  提供了一个化合物，其化学式为##STR1##其中R.sub.1从氢、较低的烷基、氯、溴、烷氧基、羟基、较低的烷基取代的硫和NR.sub.4 R.sub.5中选择，其中R.sub.4和R.sub.5为氢、较低的烷基和二取代的较低烷氨基较低烷基；R.sub.2从氢、较低的烷基和氨基中选择；R.sub.3从氢、酰氧基和羟基中选择；X为卤素，Y为氢或卤素，当R.sub.3为氢时为其N-氧化物和药用盐。吡咪唑并[4,5-d][2]苯并脑啡是作为抗焦虑和镇静剂的有效药物。还提供了制备上述吡咪唑并[4,5-d][2]苯并脑啡的过程和中间体。
• Synthesis and reactions of nickel and palladium carbon-bound enolate complexes
  作者：Elizabeth R. Burkhardt、Robert G. Bergman、Clayton H. Heathcock

  DOI：10.1021/om00115a007

  日期：1990.1
• Process for the preparation of carboxylic acid esters from organic
  申请人：The University of Delaware

  公开号：US03988358A1

  公开（公告）日：1976-10-26

  Carboxylic acid esters or amides are obtained from aryl, heterocyclic, vinylic, ethynylic, and benzylic halides and substituted derivates thereof, by reacting same with an alcohol or primary or secondary amine and carbon monoxide, in the presence of a palladium catalyst and if necessary a tertiary amine at about 20.degree.-150.degree. C and from about a half to about 100 atmospheres pressure. A typical example is the conversion of bromobenzene into n-butyl benzoate at 100.degree. C and one atmosphere of carbon monoxide in the presence of tri-n-butyl-amine and a catalytic amount of PdBr.sub.2 [P(C.sub.6 H.sub.5).sub.3 ].sub.2.

  羧酸酯或酰胺可由芳基、杂环、烯基、乙炔基和苄基卤化物及其取代物与醇或一级或二级胺以及一氧化碳在钯催化剂存在下反应而得，必要时在大约20-150摄氏度和大约半个大气压至100大气压下进行。一个典型的例子是在100摄氏度和一个大气压的一氧化碳存在下，将溴苯转化为正丁基苯甲酸酯，同时存在三正丁基胺和PdBr.sub.2[P(C.sub.6 H.sub.5).sub.3].sub.2的催化剂量。