(-)-[7,7']-spiro-6,6',7,7'-tetrahydro-bis-5H-cyclopenta[b]pyridine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: (-)-[7,7']-spiro-6,6',7,7'-tetrahydro-bis-5H-cyclopenta[b]pyridine
• 英文别名: 7,7'-Spirobi[5,6-dihydrocyclopenta[b]pyridine]；7,7'-spirobi[5,6-dihydrocyclopenta[b]pyridine]
• 化学式: C₁₅H₁₄N₂
• 分子量: 222.29
• InChiKey: ISGOASZPXYGLIE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  17
• 可旋转键数：
  0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  25.8
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  2,2-di(3-butynyl)malononitrile 在 decamethylrhenocene 作用下， 以 甲苯 为溶剂， 137.0 ℃ 、900.02 kPa 条件下， 生成 (-)-[7,7']-spiro-6,6',7,7'-tetrahydro-bis-5H-cyclopenta[b]pyridine
  参考文献：
  名称：

  One-Step Synthesis of Spiropyridines, a Novel Class of C₂-Symmetric Chiral Ligands, by Cobalt(I)-Catalyzed [2 + 2 + 2] Cycloadditions between Bis-Alkynenitriles and Alkynes

  摘要：

  Spiropyridines, a novel series of C-2-symmetric ligands, can be obtained in moderate yields by means of Co(l) catalyzed double cocyclization between bis-alkynenitriles and alkynes. This one-step method allowed the first synthesis of the interesting 7,7'- and 8,8'-spyropyridines from acyclic precursors.

  DOI：

  10.1021/ol991195m

文献信息

• One-Step Synthesis of Spiropyridines, a Novel Class of <i>C</i>₂-Symmetric Chiral Ligands, by Cobalt(I)-Catalyzed [2 + 2 + 2] Cycloadditions between Bis-Alkynenitriles and Alkynes
  作者：Jesús A. Varela、Luis Castedo、Carlos Saá

  DOI：10.1021/ol991195m

  日期：1999.12.1

  Spiropyridines, a novel series of C-2-symmetric ligands, can be obtained in moderate yields by means of Co(l) catalyzed double cocyclization between bis-alkynenitriles and alkynes. This one-step method allowed the first synthesis of the interesting 7,7'- and 8,8'-spyropyridines from acyclic precursors.