毒理性
识别和使用：全氟丁烷磺酸（PFBS）可能呈无色液体或腐蚀性固体形式。全氟烷磺酸酯在制备化学中被用作强烷基化剂。人类暴露和毒性：患有哮喘的儿童与没有哮喘的儿童相比，血清PFBS水平有显著差异。测试了四种全氟烷基化物质对人和大鼠11beta-HSD2的抑制能力，其中之一是PFBS。PFBS对人和大鼠11beta-HSD2活性的抑制能力最低。在体外研究中，PFBS没有在HepG2细胞中产生ROS或DNA损伤。PFBS抑制了PHA诱导的IL-10释放并阻止了LPS诱导的I-kappaB降解。动物研究：PFBS适度降低了小鼠的血浆甘油三酯。进行了一项为期90天的大鼠口服灌胃研究，使用PFBS的钾盐（K(+)PFBS）。没有观察到与治疗相关的死亡、体重或神经学效应。在600 mg/kg-day的雄性中观察到色素鼻涕（口周）和尿液染色的腹部毛发。在200和600 mg/kg-day的雄性中，红细胞计数、血红蛋白和血细胞比容值降低。在600 mg/kg-day的雌性中，总蛋白和白蛋白较低。仅在最高剂量的胃中观察到微观变化。在肾脏中观察到组织病理学变化，包括髓质和乳头管上皮细胞的最小到轻度增生以及内髓质区域的导管。进行了两代生殖大鼠研究，使用K(+)PFBS。在300和1000 mg/kg/day剂量组的 rats中，肝脏重量增加，相应的适应性肝细胞肥大发生率增加，在肾髓质和乳头的微观发现最小到轻度增加。在P或F1代大鼠中，没有观察到K(+)PFBS处理对生育或繁殖的影响。在雄性或雌性生殖器官中没有观察到微观变化，对精子参数、交配、动情周期、妊娠和自然分娩没有生物学相关影响。在P-或F1代中没有观察到K(+)PFBS处理对幼崽存活的影响。在任何剂量组中，窝产仔数和每窝平均产仔体重与对照组相比，统计学上没有显著差异。在F1代中，在1000 mg/kg/day的雄性中，终体重降低。在这个剂量下，包皮分离略有延迟，这一发现与体重减轻一致。在F1雌性中几乎没有观察到影响。F2幼崽体重正常。生态毒性研究：在一项蝌蚪研究中，PFBS对存活和生长没有显著影响。然而，在高浓度下，它导致了肝组织学损伤。PFBS对性别比和性腺组织学没有影响。它促进了雌激素受体（ER）和雄激素受体（AR）的表达，但未影响大脑中的芳香酶表达。
IDENTIFICATION AND USE: Perfluorobutanesulfonic acid (PFBS) can be in the form of a colorless liquid or a corrosive solid. Esters of perfluoroalkanesulfonic acids are used as strong alkylating agents in preparative chemistry. HUMAN EXPOSURE AND TOXICITY: Children with asthma have been shown to have significantly different serum PFBS levels compared to children without asthma. Inhibitory potencies of four perfluoroalkylated substances on human and rat 11beta-HSD2 were tested, one of which was PFBS. PFBS showed the lowest potency for the inhibition of human and rat 11beta-HSD2 activities. In an in vitro study, PFBS did not generate ROS or DNA damage in HepG2 cells. PFBS inhibited PHA-induced IL-10 release and prevented LPS-induced I-kappaB degradation. ANIMAL STUDIES: PFBS modestly reduced plasma triglycerides in mice. A 90-day rat oral gavage study was conducted with potassium salt of PFBS (K(+)PFBS). No treatment-related mortality, body weight, or neurological effects were noted. Chromorhinorrhea (perioral) and urine-stained abdominal fur were observed in males at 600 mg/kg-day. Red blood cell counts, hemoglobin, and hematocrit values were reduced in males receiving 200 and 600 mg/kg-day. Total protein and albumin were lower in females at 600 mg/kg-day. Microscopic changes were observed only at the highest dose in the stomach. Histopathological changes were observed in the kidneys, consisting of minimal-to-mild hyperplasia of the epithelial cells of the medullary and papillary tubules and the ducts in the inner medullary region. A two-generation reproductive rat study was conducted with K(+)PFBS. In the 300 and 1000 mg/kg/day dose group rats, there were increased liver weight and corresponding increased incidence of adaptive hepatocellular hypertrophy, and increased incidence of minimal to mild microscopic findings in the medulla and papilla of the kidneys. There were no K(+)PFBS treatment-related effects on fertility or reproduction among the P or the F1 rats. There were no microscopic changes in male or female reproductive organs, and no biologically relevant effects on sperm parameters, mating, estrous cycles, pregnancy, and natural delivery in the P- or F1-generations. There were no K(+)PFBS treatment-related effects on survival of pups. Litter size and average pup birth weight per litter were not statistically significantly different from controls in any dose group. In the F1-generation, terminal body weight was reduced in males at 1000 mg/kg/day. Preputial separation was slightly delayed at this dose, a finding consistent with the body weight reduction. Essentially no effects were observed in the F1 females. F2 pups had normal body weights. ECOTOXICITY STUDIES: In a study of tadpoles, PFBS did not have a significant effect on survival and growth. However, it caused hepatohistological impairment at higher concentrations. PFBS had no effect on the sex ratio and gonadal histology. It promoted expression of estrogen receptor (ER) and androgen receptor (AR), but did not affected aromatase expression in the brain.
来源:Hazardous Substances Data Bank (HSDB)
