21-chloro-3β-hydroxy-pregn-5-en-20-one | 30459-98-4

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: 21-chloro-3β-hydroxy-pregn-5-en-20-one
• 英文别名: 21-Chlor-3β-hydroxy-pregn-5-en-20-on；21-Chloropregn-5-en-3β-ol-20-on；2-chloro-1-[(3S,8S,9S,10R,13S,14S,17S)-3-hydroxy-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl]ethanone
• CAS: 30459-98-4
• 化学式: C₂₁H₃₁ClO₂
• 分子量: 350.929
• InChiKey: PKGVHUPHLJLSIM-WPWXJNKXSA-N

物化性质

• 沸点：
  472.4±45.0 °C(Predicted)
• 密度：
  1.16±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.8
• 重原子数：
  24
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  21-chloro-3β-hydroxy-pregn-5-en-20-one 、 溶剂黄146 、 alkaline earth salt of/the/ methylsulfuric acid 生成 21-chloro-pregnene-(4)-trione-(3.6.20)
  参考文献：
  名称：

  脱氧皮质- steron（21氧基-孕激素）AUSΔ 5 -3-氧- ATIO-cholensäure

  摘要：

  DOI：

  10.1002/hlca.193702001158
• 作为产物：
  描述：

  21-diazo-3β-hydroxy-pregn-5-en-20-one 在 盐酸 、 乙醚 作用下， 生成 21-chloro-3β-hydroxy-pregn-5-en-20-one
  参考文献：
  名称：

  ÜberBestandteile der Nebennierenrinde und verwandte Stoffe（27.米特伊龙）。Δ 4 -3-酮- androstenyl -乙二醛-17 UND verwandte Stoffe

  摘要：

  DOI：

  10.1002/hlca.193902201139

文献信息

• Über Steroide und Sexualhormone. 173. Mitteilung. Synthese des 17-Methyl-progesterons B
  作者：H. Heusser、Ch. R. Engel、Pl. A. Plattner

  DOI：10.1002/hlca.19500330732

  日期：——

  Es wird die Synthese des 17-Methyl-progesterons B, eines neuen, biologisch unwirksamen Homologen des Corpus luteum-Hormons, beschrieben.

  描述了17-甲基黄体酮B的合成，黄体激素是一种新的，生物学上无活性的同源物。
• A new method for the selective halogenation of the methyl group of methyl ketones
  作者：J.F.W. Keana、R.R. Schumaker

  DOI：10.1016/s0040-4020(01)98727-7

  日期：1970.1

  either NCS or- NBS in ether at 25° followed by mild acidic hydrolysis has led to the corresponding 21-haloketones in high yield. Application of this halogenation procedure to 2-pentanone demonstrated that this method may be general for the selective halogenation of the Me group of methylketones.

  用NCS或-NBS在乙醚中于25°处理乙醇胺衍生的2个甾体20-酮的酮亚胺，然后进行温和的酸性水解，从而以高收率得到了相应的21-卤代酮。该卤化方法在2-戊酮上的应用证明，该方法对于甲基卤代Me的Me基团的选择性卤化可能是通用的。
• Acute arterial thrombosis with antithrombin III deficiency in nephrotic syndrome: Report of a case
  作者：Motohiro Nishimura、Junichi Shimada、Kazuhiro Ito、Hideyuki Kawachi、Katsuhiko Nishiyama

  DOI：10.1007/s005950070110

  日期：2000.7

  Nephrotic syndrome frequently causes venous thromboembolic complications. Arterial thrombosis has rarely been reported and is mainly observed in children. Only six cases of lower extremity arterial thrombosis in adults have been reported in the literature. The outcome in these cases was unsatisfactory because of the high rates of limb loss and recurrence of thrombosis. We report successful treatment of a 39-year-old man who suffered from right lower extremity arterial thrombosis associated with decreased levels of serum antithrombin III. He was admitted to our hospital with severe pain in his right foot. No pulse was palpable in his right dorsalis pedis or posterior tibial arteries. His right foot was cold and mottled, with a reduced sensation and motor activity. The laboratory data revealed a serum total protein concentration of 3.9 g/dl and an albumin concentration of 1.5 g/dl. The coagulation profile showed a fibrinogen level of 879 mg/dl and antithrombin III value of 9.5%. Right lower extremity arteriography showed a complete occlusion of the right deep femoral artery and popliteal artery, and a filling defect in the common femoral artery. An emergency thrombectomy was performed under general anesthesia. The patient was treated successfully, and surgical treatment was followed by anticoagulant therapy with 1 000 units of antithrombin III. A renal biopsy revealed histologic evidence of minimal change of glomerulonephritis. He was discharged 3 months later, and no recurrence of thrombosis has yet been observed.
• Compounds of the cyclopentanopolyhydrophenanthrene series and process of making same
  申请人：CIBA PHARM PROD INC

  公开号：US02229818A1

  公开（公告）日：1941-01-28
• CH215139
  申请人：——

  公开号：——

  公开（公告）日：——