2-[(E)-Isopropylimino-methyl]-phenol | 135609-63-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 英文名称: 2-[(E)-Isopropylimino-methyl]-phenol
• 英文别名: 2-Isopropyliminomethylphenol
• CAS: 135609-63-1
• 化学式: C₁₀H₁₃NO
• 分子量: 163.219
• InChiKey: PHHCWZIPEJJCOE-YRNVUSSQSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.22
• 重原子数：
  12.0
• 可旋转键数：
  2.0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  32.59
• 氢给体数：
  1.0
• 氢受体数：
  2.0

反应信息

• 作为反应物：
  描述：

  2-[(E)-Isopropylimino-methyl]-phenol 在 氯化亚砜 作用下， 以 氯仿 、 1,2-二氯乙烷 为溶剂， 反应 2.0h， 生成 methyl trans-2-isopropyl-3-(2-hydroxyphenyl)-3,4-dihydro-1(2H)-isoquinoline-4-carboxylate
  参考文献：
  名称：

  11H-4b，10b-二氢[1]苯并吡喃[4,3-c]异喹啉-6,11（5H）-二酮和13H-6c，12b-二氢萘[1'，2'：5,6]-的合成由高邻苯二甲酸酐和N-（2-羟基亚芳基）烷基胺形成的吡喃并[4-3c]异喹啉-8,13（7H）-二酮

  摘要：

  由高邻苯二甲酸酐（1）和N-（2-羟基亚芳基）制备2-烷基-3-（2-羟基芳基）-3,4-二氢-1（2H）-异喹啉酮-4-羧酸（5,13）烷基胺（2,10）。酸5,13表现出环脱水的趋势，以生成具有稠合的[1]苯并吡喃（8）或萘并吡喃（12）环系统的异喹啉衍生物。通过NMR研究确定了新颖的稠合杂环化合物5、8、12、13和相关化合物的相对构型，并且在13的情况下也通过X射线分析来确定。在某些选定的稠合杂环上进行了一些MM2力场分子力学计算。迄今为止，尚未报道内酯12中并入的萘并[1'，2'：5,6]吡喃并[4,3c]-异喹啉环系统。

  DOI：

  10.1016/s0040-4020(01)85515-0
• 作为产物：
  描述：

  在 偶氮二异丁腈 、 三正丁基氢锡 、 sodium tetrahydroborate 作用下， 以 苯 、 甲醇 为溶剂， 生成 2-[(E)-Isopropylimino-methyl]-phenol
  参考文献：
  名称：

  Investigations into a free radical-mediated 1,2-imino migration

  摘要：

  The radical reactions of a series of bromides 9a-c and selenides 12-15 have been investigated to determine the factors that are important for a successful radical-mediated 1,2-imino migration. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2004.09.151

文献信息

• Non-metallocene compounds, method for the production thereof and use of the same for the polymerisation of olefins
  申请人：——

  公开号：US20040023940A1

  公开（公告）日：2004-02-05

  The invention relates to a method for producing special transition metal compounds, to novel transition metal compounds and to the use of the same for the polymerisation of olefins.

  这项发明涉及一种生产特殊过渡金属化合物的方法，新型过渡金属化合物以及将其用于烯烃聚合的用途。
• PROCESS FOR THE PREPARATION OF OPTIONALLY SUBSTITUTED PHENYL AND PYRIDYL PYRROLIDINES
  申请人：BAYER CROPSCIENCE AG

  公开号：US20150246880A1

  公开（公告）日：2015-09-03

  The present invention relates to a method for the preparation of optionally substituted aryl and pyridyl pyrrolidines which are useful intermediates for the preparation of certain biologically active compounds.

  本发明涉及一种制备可选取代芳基和吡啶基吡咯烷的方法，这些化合物是制备某些生物活性化合物的有用中间体。
• POLYLACTIC ACID COMPOSITION
  申请人：Teijin Limited

  公开号：EP2116576A1

  公开（公告）日：2009-11-11

  It is an object of the present invention to provide a polylactic acid composition having excellent crystallinity, wet heat stability and melt stability. It is another object of the present invention to provide a molded article which is obtained from the polylactic acid composition and excellent in appearance and color. The present invention is a composition and molded article thereof which comprises a polylactic acid (component A), a carbodiimide compound (component B) and a phosphoric acid ester metal salt (component C).

  本发明的一个目的是提供一种具有优异结晶度、湿热稳定性和熔融稳定性的聚乳酸组合物。本发明的另一个目的是提供一种由该聚乳酸组合物制成的模塑制品，其外观和色泽极佳。 本发明是一种由聚乳酸（A 组分）、碳化二亚胺化合物（B 组分）和磷酸酯金属盐（C 组分）组成的组合物及其成型品。
• Equilibriums and absorption spectra of Schiff bases
  作者：Carol M. Metzler、Allen Cahill、David E. Metzler

  DOI：10.1021/ja00539a017

  日期：1980.9
• Synthesis, characterization, crystal structure and DNA, HSA-binding studies of four Schiff base complexes derived from salicylaldehyde and isopropylamine
  作者：Monireh Dehkhodaei、Mahsa Khorshidifard、Hadi Amiri Rudbari、Mehdi Sahihi、Gholamhassan Azimi、Neda Habibi、Salman Taheri、Giuseppe Bruno、Reza Azadbakht

  DOI：10.1016/j.ica.2017.05.035

  日期：2017.9

  Four new Schiff base complexes (NiL2, CoL2, CuL2 and ZnL2) (HL: ((E)-2-((isopropylamino) methyl) phenol) were synthesized and characterized by CHN elemental analysis, FT-IR and single crystal X-ray diffraction technique. The crystallographic data reveal that in all complexes the metal centers are four-coordinated by two phenolate oxygen and two imine nitrogen atoms of two moles of Schiff base ligand HL and geometry around the metal center in all of them is distorted tetrahedral. In addition, H-1 and C-13 NMR techniques were employed for characterization of diamagnetic ZnL2 complex. The binding affinity of complexes with DNA (fish sperm DNA, FS-DNA) and Human Serum Albumin (HSA) were investigated using fluorescence quenching, chemometrics, UV-Vis spectroscopy, viscosity measurements and molecular docking methods. The obtained results revealed that the DNA and HSA affinity for binding to complexes are in the following order: CuL2 > ZnL2 > CoL2 > NiL2 and NiL2 > ZnL2 > CuL2 > CoL2. The distance between complexes and HSA was obtained based on the Forster's theory of non-radiative energy transfer. The computational molecular docking results showed that H-bond interactions, hydrophobic interactions, pi-pi stacking and pi-cation interactions have dominant role in the stability of HSA-ML2 (M: Cu, Co, Ni and Zn). The computational docking and viscosity results suggest that all metal complexes interact with DNA presumably by the groove binding mechanism. (c) 2017 Elsevier B.V. All rights reserved.