Synthesis of pyrrolo[2,3-d]pyrimidine nucleoside derivatives as potential anti-HCV agents
摘要:
Several Toyocamycin (4) analogues were examined for their ability to inhibit HCV RNA in a replicon assay. Among the compounds examined 4-methylthio (18) and 5-carboxamide oxime derivatives (23 and 27) of Toyocamycin were found to have good activity and selectivity. (c) 2006 Elsevier Inc. All rights reserved.
[EN] DEAZAPURINE NUCLEOSIDE LIBRARIES AND COMPOUNDS<br/>[FR] BANQUES DE DEAZAPURINE NUCLEOSIDES ET COMPOSES
申请人:RIBAPHARM INC
公开号:WO2003051899A1
公开(公告)日:2003-06-26
Deazapurine nucleoside analog libraries are prepared in a combinatorial library approach. Particularly preferred compounds and libraries include various 7-deazapurines, 9-deazapurines, and 7-deaza-8-azaguanosine as heterocyclic bases, and it is generally preferred that such nucleosides include a ribofuranose as the sugar moiety. It is further contemplated that compounds generated using contemplated libraries may be useful in the treatment of various conditions, particularly viral infections and neoplastic diseases.