首页分子通化学资讯化学百科反应查询关于我们

请输入关键词

历史搜索

热门化合物HOT

喹啉
水杨醛
二溴甲烷
谷胱甘肽
L-乳酸
苯巴比妥
辣椒碱
非那明
百草枯
联苯烯

3-[(1S)-1-氨基乙基]-8-氯-2-苯基-1(2H)-异喹啉酮 | 1350643-72-9

物质功能分类

医药中间体 - 原料药中间体

分子结构分类

有机化合物 - 有机杂环化合物 - 异喹啉及其衍生物

中文名称

3-[(1S)-1-氨基乙基]-8-氯-2-苯基-1(2H)-异喹啉酮

中文别名

3-[((1S)-1-氨乙基]-8-氯-2-苯基-1,2-二氢异喹啉-1-酮

英文名称

(S)-3-(1-aminoethyl)-8-chloro-2-phenylisoquinolin-1(2H)-one

英文别名

(S)-3-(1-aminoethyl)-8-chloro-2-phenylisoquinoline-1(2H)-one；3-[(1S)-1-aminoethyl]-8-chloro-2-phenylisoquinolin-1-one

CAS

1350643-72-9

化学式

C₁₇H₁₅ClN₂O

mdl

——

分子量

298.772

InChiKey

MZINZXIFJMLTOK-NSHDSACASA-N

BEILSTEIN

——

EINECS

——

物化性质

沸点：

477.9±45.0 °C(Predicted)
密度：

1.296±0.06 g/cm3(Predicted)

计算性质

辛醇/水分配系数(LogP)：

3
重原子数：

21
可旋转键数：

2
环数：

3.0
sp3杂化的碳原子比例：

0.12
拓扑面积：

46.3
氢给体数：

1
氢受体数：

2

安全信息

危险性防范说明：

P261,P305+P351+P338
危险性描述：

H302,H315,H319,H335
储存条件：

室温、密闭保存，并保持干燥。

制备方法与用途

IPI145中间体可以用于有机合成和医药合成的中间步骤，在实验室有机合成及化工医药的研发过程中发挥重要作用。

上下游信息

下游产品

中文名称	英文名称	CAS号	化学式	分子量
——	(S)-N-(1-(8-chloro-1-oxo-2-phenyl-1,2-dihydroisoquinolin-3yl)ethyl)-2-cyanoacetamide	1466565-67-2	C₂₀H₁₆ClN₃O₂	365.819
——	(S)-N-(1-(8-chloro-1-oxo-2-phenyl-1,2-dihydroisoquinoline-3-yl)ethyl)-2,2,2-trifluoroacetamide	1466565-90-1	C₁₉H₁₄ClF₃N₂O₂	394.781
——	(S)-tert-butyl (1-(8-chloro-1-oxo-2-phenyl-1,2-dihydroisoquinolin-3-yl)ethyl)carbamate	1425044-76-3	C₂₂H₂₃ClN₂O₃	398.889
——	3-[(1S)-1-[(2-aminopyridin-3-yl)methylamino]ethyl]-8-chloro-2-phenylisoquinolin-1-one	1420623-03-5	C₂₃H₂₁ClN₄O	404.899
——	(S)-3-(1-aminoethyl)-4-bromo-8-chloro-2-phenylisoquinolin-1(2H)-one	1466565-92-3	C₁₇H₁₄BrClN₂O	377.668
——	(S)-3-(1-(6-aminopyrimidin-4-ylamino)ethyl)-8-chloro-2-phenylisoquinolin-1(2H)-one	1425042-38-1	C₂₁H₁₈ClN₅O	391.86
——	(S)-8-chloro-3-(1-(6-chloropyrimidin-4-ylamino)ethyl)-2-phenylisoquinolin-1(2H)-one	1425042-37-0	C₂₁H₁₆Cl₂N₄O	411.29
——	(S)-N-(1-(8-chloro-1-oxo-2-phenyl-1,2-dihydroisoquinolin-3-yl)ethyl)nicotinamide	1466563-81-4	C₂₃H₁₈ClN₃O₂	403.868
——	3-[(1S)-1-[(5-bromopyrimidin-4-yl)amino]ethyl]-8-chloro-2-phenylisoquinolin-1-one	1425045-78-8	C₂₁H₁₆BrClN₄O	455.741
——	8-chloro-3-[(1S)-1-[(3-chloro-1,2,4-thiadiazol-5-yl)amino]ethyl]-2-phenylisoquinolin-1-one	1420623-46-6	C₁₉H₁₄Cl₂N₄OS	417.318
——	(S)-3-(1-((2-amino-6-methylpyrimidin-4-yl)amino)ethyl)-8-chloro-2-phenylisoquinolin-1(2H)-one	1425042-43-8	C₂₂H₂₀ClN₅O	405.887
——	3-[(1S)-1-[(2-amino-5-bromopyrimidin-4-yl)amino]ethyl]-8-chloro-2-phenylisoquinolin-1-one	1425045-83-5	C₂₁H₁₇BrClN₅O	470.756
——	(S)-2-amino-N-(1-(8-chloro-1-oxo-2-phenyl-1,2-dihydroisoquinolin-3-yl)ethyl)thiazole-5-carboxamide	1466563-34-7	C₂₁H₁₇ClN₄O₂S	424.911
——	3-[(1S)-1-[(2-amino-5-ethynylpyrimidin-4-yl)amino]ethyl]-8-chloro-2-phenylisoquinolin-1-one	1425042-42-7	C₂₃H₁₈ClN₅O	415.882
——	N-[(1S)-1-(4-bromo-8-chloro-1-oxo-2-phenylisoquinolin-3-yl)ethyl]-2,2,2-trifluoroacetamide	1466565-91-2	C₁₉H₁₃BrClF₃N₂O₂	473.677
——	8-chloro-3-[(1S)-1-(imidazo[1,2-b]pyridazin-3-ylmethylamino)ethyl]-2-phenylisoquinolin-1-one	1420623-06-8	C₂₄H₂₀ClN₅O	429.909
——	(S)-2,4-diamino-6-((1-(8-chloro-1-oxo-2-phenyl-1,2-dihydroisoquinolin-3-yl)ethyl)amino)pyrimidine-5-carbonitrile	——	C₂₂H₁₈ClN₇O	431.884
——	3-[(1S)-1-aminoethyl]-2,8-diphenylisoquinolin-1-one	1466565-58-1	C₂₃H₂₀N₂O	340.425
——	(S)-3-(1-aminoethyl)-8-(dimethylamino)-2-phenylisoquinolin-1(2H)-one	1466565-75-2	C₁₉H₂₁N₃O	307.395
(S)-3-(1-((9H-嘌呤-6-基)氨基)乙基)-8-氯-2-苯基-1(2H)-异喹啉酮	duvelisib	1201438-56-3	C₂₂H₁₇ClN₆O	416.87
——	3-[(1S)-1-[[2-amino-5-(2-trimethylsilylethynyl)pyrimidin-4-yl]amino]ethyl]-8-chloro-2-phenylisoquinolin-1-one	1425044-64-9	C₂₆H₂₆ClN₅OSi	488.064
——	N-[2-chloro-4-[[(1S)-1-(8-chloro-1-oxo-2-phenylisoquinolin-3-yl)ethyl]amino]pyrimidin-5-yl]acetamide	1425044-89-8	C₂₃H₁₉Cl₂N₅O₂	468.342
——	N-[(1S)-1-(8-chloro-1-oxo-2-phenylisoquinolin-3-yl)ethyl]-1,6-naphthyridine-8-carboxamide	1466563-75-6	C₂₆H₁₉ClN₄O₂	454.915
——	3-amino-6-bromo-N-[(1S)-1-(8-chloro-1-oxo-2-phenylisoquinolin-3-yl)ethyl]pyrazine-2-carboxamide	1466563-47-2	C₂₂H₁₇BrClN₅O₂	498.766
——	(S)-8-chloro-3-(1-(2-chloro-5-nitropyrimidin-4-ylamino)ethyl)-2-phenylisoquinolin-1(2H)-one	1420628-48-3	C₂₁H₁₅Cl₂N₅O₃	456.288
——	N-[(1S)-1-(8-chloro-1-oxo-2-phenylisoquinolin-3-yl)ethyl]imidazo[1,2-a]pyridine-3-carboxamide	1466563-51-8	C₂₅H₁₉ClN₄O₂	442.904
——	(S)-2-amino-4-((1-(8-chloro-1-oxo-2-phenyl-1,2-dihydroisoquinolin-3-yl)ethyl)amino)-6-methylpyrimidine-5-carbonitrile	1425042-41-6	C₂₃H₁₉ClN₆O	430.896
——	(S)-3-(1-(2-amino-5-phenylpyrimidin-4-ylamino)ethyl)-8-chloro-2-phenylisoquinolin-1(2H)-one	1425042-39-2	C₂₇H₂₂ClN₅O	467.958
——	8-chloro-2-phenyl-3-[(1S)-1-([1,3]thiazolo[5,4-b]pyridin-7-ylamino)ethyl]isoquinolin-1-one	1420829-86-2	C₂₃H₁₇ClN₄OS	432.933
——	N-[2-chloro-4-[[(1S)-1-(8-chloro-1-oxo-2-phenylisoquinolin-3-yl)ethyl]amino]pyrimidin-5-yl]benzamide	1425044-90-1	C₂₈H₂₁Cl₂N₅O₂	530.413
——	N-(1-(8-chloro-1-oxo-2-phenyl-1,2-dihydroisoquinolin-3-yl)ethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide	1466563-52-9	C₂₄H₁₈ClN₅O₂	443.892
——	3-[(1S)-1-[[2-amino-5-(2-methylpropanoyl)pyrimidin-4-yl]amino]ethyl]-8-chloro-2-phenylisoquinolin-1-one	1425044-25-2	C₂₅H₂₄ClN₅O₂	461.951
——	(S)-3-(1-(2-amino-5-(methylsulfonyl)pyrimidin-4-ylamino)ethyl)-8-chloro-2-phenylisoquinolin-1(2H)-one	1425042-40-5	C₂₂H₂₀ClN₅O₃S	469.952
——	8-chloro-2-phenyl-3-[(1S)-1-(pyrido[3,2-d]pyrimidin-4-ylamino)ethyl]isoquinolin-1-one	1420618-39-8	C₂₄H₁₈ClN₅O	427.893
——	3-[(1S)-1-aminoethyl]-8-(2-methoxypyrimidin-5-yl)-2-phenyl-isoquinolin-1-one	1420627-92-4	C₂₂H₂₀N₄O₂	372.426
——	(S)-3-(1-aminoethyl)-8-(1-methyl-1H-pyrazol-4-yl)-2-phenylisoquinolin-1(2H)-one	1350643-65-0	C₂₁H₂₀N₄O	344.416
——	3-[(1S)-1-[(2-aminopteridin-4-yl)amino]ethyl]-8-chloro-2-phenylisoquinolin-1-one	1420623-31-9	C₂₃H₁₈ClN₇O	443.895
——	cyclopropyl ketone	1425044-26-3	C₂₅H₂₂ClN₅O₂	459.935
——	8-chloro-3-[(1S)-1-[(2-chloropteridin-4-yl)amino]ethyl]-2-phenylisoquinolin-1-one	1420623-25-1	C₂₃H₁₆Cl₂N₆O	463.326
——	(S)-3-(1-aminoethyl)-8-(2-methoxypyridin-4-yl)-2-phenylisoquinolin-1 (2H)-one	1425045-77-7	C₂₃H₂₁N₃O₂	371.439
——	8-chloro-2-phenyl-3-[(1S)-1-([1,3]thiazolo[5,4-d]pyrimidin-7-ylamino)ethyl]isoquinolin-1-one	1420829-02-2	C₂₂H₁₆ClN₅OS	433.921
——	8-chloro-3-[(1S)-1-[(2,7-dichloropteridin-4-yl)amino]ethyl]-2-phenylisoquinolin-1-one	1420623-22-8	C₂₃H₁₅Cl₃N₆O	497.771
——	2-amino-4-[[(1S)-1-(1-oxo-2-phenylisoquinolin-3-yl)ethyl]amino]pyrimidine-5-carbonitrile	1425042-63-2	C₂₂H₁₈N₆O	382.425
——	7-amino-N-[(1S)-1-(8-chloro-1-oxo-2-phenylisoquinolin-3-yl)ethyl]-1,6-naphthyridine-8-carboxamide	1466564-54-4	C₂₆H₂₀ClN₅O₂	469.93
——	3-[(1S)-1-[[2-amino-5-(4-methyl-1,3-thiazol-2-yl)pyrimidin-4-yl]amino]ethyl]-8-chloro-2-phenylisoquinolin-1-one	1425042-71-2	C₂₅H₂₁ClN₆OS	489.0
——	(S)-3-(1-((6-amino-5-(5-methyl-1,3,4-oxadiazol-2-yl)pyrimidin-4-yl)amino)ethyl)-8-chloro-2-phenylisoquinolin-1(2H)-one	——	C₂₄H₂₀ClN₇O₂	473.922
——	tert-butyl (S)-(1-(1-oxo-2-phenyl-8-((trimethylsilyl)ethynyl)-1,2-dihydroisoquinolin-3-yl)ethyl)carbamate	1425044-92-3	C₂₇H₃₂N₂O₃Si	460.648
——	2-amino-N-[(1S)-1-(8-chloro-1-oxo-2-phenyl-1,2-dihydroisoquinolin-3-yl)ethyl]pyrazolo[1.5-a]pyrimidine-3-carboxamide	1466563-97-2	C₂₄H₁₉ClN₆O₂	458.907
——	3-[2-amino-4-[[(1S)-1-(8-chloro-1-oxo-2-phenylisoquinolin-3-yl)ethyl]amino]pyrimidin-5-yl]-N,N-dimethylbenzenesulfonamide	1425044-17-2	C₂₉H₂₇ClN₆O₃S	575.091
——	3-[(1S)-1-aminoethyl]-8-(6-methoxypyrazin-2-yl)-2-phenylisoquinolin-1-one	1425045-00-6	C₂₂H₂₀N₄O₂	372.426
——	3-[(1S)-1-[[2-amino-5-(3-piperidin-1-ylsulfonylphenyl)pyrimidin-4-yl]amino]ethyl]-8-chloro-2-phenylisoquinolin-1-one	1425042-82-5	C₃₂H₃₁ClN₆O₃S	615.156
——	tert-butyl N-[(1S)-1-[1-oxo-2-phenyl-8-(1H-pyrazol-5-yl)isoquinolin-3-yl]ethyl]carbamate	1466563-92-7	C₂₅H₂₆N₄O₃	430.506
——	(S)-3-(1-((9H-purin-6-yl)amino)ethyl)-1-oxo-2-phenyl-1,2-dihydroisoquinoline-8-carbonitrile	1350643-17-2	C₂₃H₁₇N₇O	407.434
——	2-amino-N-[(1S)-1-(8-chloro-1-oxo-2-phenylisoquinolin-3-yl)ethyl]furo[3,2-b]pyridine-3-carboxamide	1466565-51-4	C₂₅H₁₉ClN₄O₃	458.904
——	(S)-3-(1-((9H-purin-6-yl)amino)ethyl)-1-oxo-2-phenyl-1,2-dihydroisoquinoline-8-carbaldehyde	1350643-63-8	C₂₃H₁₈N₆O₂	410.435
——	(S)-3-(1-((9H-purin-6-yl)amino)ethyl)-8-ethyl-2-phenylisoquinolin-1(2H)-one	1350643-14-9	C₂₄H₂₂N₆O	410.478
——	2-amino-4-[[(1S)-1-[1-oxo-8-(5-oxo-5-pyrrolidin-1-ylpent-1-ynyl)-2-phenylisoquinolin-3-yl]ethyl]amino]pyrimidine-5-carbonitrile	1425043-12-4	C₃₁H₂₉N₇O₂	531.617
IPI145中间体-5	8-chloro-2-phenyl-3-((1S)-1-(9-(tetrahydro-2H-pyran-2-yl)-9H-purin-6-ylamino)ethyl)isoquinolin-1(2H)-one	1350643-73-0	C₂₇H₂₅ClN₆O₂	500.988
——	tert-butyl N-[3-[[(1S)-1-(8-chloro-1-oxo-2-phenylisoquinolin-3-yl)ethyl]carbamoyl]pyrazolo[1,5-a]pyrimidin-2-yl]carbamate	1466563-96-1	C₂₉H₂₇ClN₆O₄	559.024
——	2-amino-4-[[(1S)-1-[8-(5-morpholin-4-yl-5-oxopent-1-ynyl)-1-oxo-2-phenylisoquinolin-3-yl]ethyl]amino]pyrimidine-5-carbonitrile	1425043-05-5	C₃₁H₂₉N₇O₃	547.616
——	(S)-2-amino-4-((1-(8-(2-methoxypyrimidin-5-yl)-1-oxo-2-phenyl-1,2-dihydroisoquinolin-3-yl)ethyl)amino)pyrimidine-5-carbonitrile	1425041-69-5	C₂₇H₂₂N₈O₂	490.524
——	2-amino-4-((S)-1-(8-(5-hydroxypyridin-3-yl)-1-oxo-2-phenyl-1,2-dihydroisoquinolin-3-yl)ethylamino)pyrimidine-5-carbonitrile	1425041-75-3	C₂₇H₂₁N₇O₂	475.509
——	(S)-2-amino-4-((1-(8-(2-methoxypyridin-4-yl)-1-oxo-2-phenyl-1,2-dihydroisoquinolin-3-yl)ethyl)amino)pyrimidine-5-carbonitrile	1425042-18-7	C₂₈H₂₃N₇O₂	489.536
——	2-amino-4-[[(1S)-1-[8-(5-methoxypyrimidin-2-yl)-1-oxo-2-phenylisoquinolin-3-yl]ethyl]amino]pyrimidine-5-carbonitrile	1425049-12-2	C₂₇H₂₂N₈O₂	490.524
——	2-amino-4-[[(1S)-1-[1-oxo-2-phenyl-8-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)isoquinolin-3-yl]ethyl]amino]pyrimidine-5-carbonitrile	1425044-91-2	C₂₈H₂₉BN₆O₃	508.388
——	(S)-2-amino-4-((1-(8-(5-methoxypyridin-3-yl)-1-oxo-2-phenyl-1,2-dihydroisoquinolin-3-yl)ethyl)amino)pyrimidine-5-carbonitrile	1425041-71-9	C₂₈H₂₃N₇O₂	489.536
——	2-amino-4-[[(1S)-1-[8-[5-(difluoromethoxy)pyridin-3-yl]-1-oxo-2-phenylisoquinolin-3-yl]ethyl]amino]pyrimidine-5-carbonitrile	1425042-77-8	C₂₈H₂₁F₂N₇O₂	525.517
——	(S)-2-amino-4-((1-(8-(1-methyl-1H-pyrazol-4-yl)-1-oxo-2-phenyl-1,2-dihydroisoquinolin-3-yl)ethyl)amino)pyrimidine-5-carboxamide	1350643-62-7	C₂₆H₂₄N₈O₂	480.529
——	8-(2-methylpyrimidin-5-yl)-2-phenyl-3-[(1S)-1-(pyrido[3,2-d]pyrimidin-4-ylamino)ethyl]isoquinolin-1-one	1420619-03-9	C₂₉H₂₃N₇O	485.548
——	(S)-2-amino-4-((1-(8-(2-methoxypyrimidin-5-yl)-1-oxo-2-phenyl-1,2-dihydroisoquinolin-3-yl)ethyl)amino)pyrimidine-5-carboxamide	1425041-73-1	C₂₇H₂₄N₈O₃	508.539
——	8-(1-methylpyrazol-4-yl)-2-phenyl-3-[(1S)-1-(pyrido[3,2-d]pyrimidin-4-ylamino)ethyl]isoquinolin-1-one	1420618-60-5	C₂₈H₂₃N₇O	473.537
——	2-amino-4-[[(1S)-1-[8-(2-methyl-1,3-thiazol-5-yl)-1-oxo-2-phenylisoquinolin-3-yl]ethyl]amino]pyrimidine-5-carbonitrile	1425042-32-5	C₂₆H₂₁N₇OS	479.565
——	2-phenyl-8-pyridazin-4-yl-3-[(1S)-1-([1,3]thiazolo[5,4-d]pyrimidin-7-ylamino)ethyl]isoquinolin-1-one	1420829-90-8	C₂₆H₁₉N₇OS	477.549
——	2-amino-4-((S)-1-(8-(5-methoxypyridin-3-yl)-1-oxo-2-phenyl-1,2-dihydroisoquinolin-3-yl)ethylamino)pyrimidine-5-carboxamide	1425041-72-0	C₂₈H₂₅N₇O₃	507.552
——	2-amino-N-[(1S)-1-(8-cyano-1-oxo-2-phenylisoquinolin-3-yl)ethyl]pyrazolo[1,5-a]pyrimidine-3-carboxamide	1466565-12-7	C₂₅H₁₉N₇O₂	449.472
——	8-(1-methylpyrazol-4-yl)-2-phenyl-3-[(1S)-1-([1,3]thiazolo[5,4-d]pyrimidin-7-ylamino)ethyl]isoquinolin-1-one	1420829-04-4	C₂₆H₂₁N₇OS	479.565
——	8-(5-aminopyridin-3-yl)-2-phenyl-3-[(1S)-1-([1,3]thiazolo[5,4-d]pyrimidin-7-ylamino)ethyl]isoquinolin-1-one	1420830-03-0	C₂₇H₂₁N₇OS	491.576
——	2-phenyl-3-[(1S)-1-([1,3]thiazolo[5,4-d]pyrimidin-7-ylamino)ethyl]-8-[2-(trifluoromethyl)pyridin-4-yl]isoquinolin-1-one	1420829-13-5	C₂₈H₁₉F₃N₆OS	544.56
——	(S)-2-amino-N-(1-(8-formyl-1-oxo-2-phenyl-1,2-dihydroisoquinolin-3-yl)ethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide hydrochloride	1466564-97-5	C₂₅H₂₀N₆O₃	452.472
——	2-amino-N-[(1S)-1-[8-(hydroxymethyl)-1-oxo-2-phenylisoquinolin-3-yl]ethyl]pyrazolo[1,5-a]pyrimidine-3-carboxamide	1466565-13-8	C₂₅H₂₂N₆O₃	454.488
——	2-amino-4-[[(1S)-1-[8-(2-methoxy-1,3-thiazol-5-yl)-1-oxo-2-phenylisoquinolin-3-yl]ethyl]amino]pyrimidine-5-carbonitrile	1425042-33-6	C₂₆H₂₁N₇O₂S	495.564
——	2-amino-N-[(1S)-1-[8-(methylaminomethyl)-1-oxo-2-phenylisoquinolin-3-yl]ethyl]pyrazolo[1,5-a]pyrimidine-3-carboxamide	1466565-15-0	C₂₆H₂₅N₇O₂	467.53
——	(S)-2-amino-N-(1-(8-ethynyl-1-oxo-2-phenyl-1,2-dihydroisoquinolin-3-yl)ethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide	1466565-45-6	C₂₆H₂₀N₆O₂	448.484
——	(S)-2-amino-N-(1-(1-oxo-2-phenyl-8-((trimethylsilyl)ethynyl)-1,2-dihydroisoquinolin-3-yl)ethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide	1466566-15-3	C₂₉H₂₈N₆O₂Si	520.666
——	2-amino-N-[(1S)-1-(1-oxo-2-phenyl-8-prop-1-ynylisoquinolin-3-yl)ethyl]pyrazolo[1,5-a]pyrimidine-3-carboxamide	1466564-79-3	C₂₇H₂₂N₆O₂	462.511
——	2-amino-N-(1-(8-(3-aminoprop-1-yn-1-yl)-1-oxo-2-phenyl-1,2-dihydroisoquinolin-3-yl)ethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide	1466564-65-7	C₂₇H₂₃N₇O₂	477.525
——	2-amino-N-[(1S)-1-[1-oxo-8-[[[(2R)-oxolan-2-yl]methylamino]methyl]-2-phenylisoquinolin-3-yl]ethyl]pyrazolo[1,5-a]pyrimidine-3-carboxamide	1466565-14-9	C₃₀H₃₁N₇O₃	537.621
——	2-amino-N-[(1S)-1-[8-(dimethylamino)-1-oxo-2-phenylisoquinolin-3-yl]ethyl]pyrazolo[1,5-a]pyrimidine-3-carboxamide	1466564-84-0	C₂₆H₂₅N₇O₂	467.53
——	2-amino-N-[(1S)-1-[8-[3-(methanesulfonamido)prop-1-ynyl]-1-oxo-2-phenylisoquinolin-3-yl]ethyl]pyrazolo[1,5-a]pyrimidine-3-carboxamide	1466564-89-5	C₂₈H₂₅N₇O₄S	555.617
——	7-amino-N-[(1S)-1-(8-morpholin-4-yl-1-oxo-2-phenylisoquinolin-3-yl)ethyl]-1,6-naphthyridine-8-carboxamide	1466565-03-6	C₃₀H₂₈N₆O₃	520.591
——	3-[(1S)-1-[[2-amino-5-(2-ethoxy-1,3-thiazol-4-yl)pyrimidin-4-yl]amino]ethyl]-8-(1-methyl-6-oxopyridin-3-yl)-2-phenylisoquinolin-1-one	1425042-72-3	C₃₂H₂₉N₇O₃S	591.693
——	tert-butyl N-[3-[[(1S)-1-(1-oxo-2-phenylisoquinolin-3-yl)ethyl]carbamoyl]pyrazolo[1,5-a]pyrimidin-2-yl]carbamate	1466565-64-9	C₂₉H₂₈N₆O₄	524.579
IPI-549,一种有效的选择性PI3KΓ抑制剂	IPI-549	1693758-51-8	C₃₀H₂₄N₈O₂	528.573
——	2-amino-N-[(1S)-1-[8-(1,2-dihydroxy-2-phenylethyl)-1-oxo-2-phenylisoquinolin-3-yl]ethyl]pyrazolo[1,5-a]pyrimidine-3-carboxamide	1466566-07-3	C₃₂H₂₈N₆O₄	560.612
——	7-amino-N-[(1S)-1-[8-(2-methoxypyridin-4-yl)-1-oxo-2-phenylisoquinolin-3-yl]ethyl]-1,6-naphthyridine-8-carboxamide	1466564-57-7	C₃₂H₂₆N₆O₃	542.597
——	2-amino-N-[(1S)-1-[1-oxo-2-phenyl-8-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)isoquinolin-3-yl]ethyl]pyrazolo[1,5-a]pyrimidine-3-carboxamide	1466565-89-8	C₃₀H₃₁BN₆O₄	550.425
——	8-(6-methylpyridin-3-yl)-2-phenyl-3-((S)-l-(9-(tetrahydro-2H-pyran-2-yl)-9H-purin-6-ylamino)ethyl)isoquinolin-1(2H)-one	1350643-75-2	C₃₃H₃₁N₇O₂	557.655
——	tert-butyl N-[3-[[(1S)-1-(8-hydroxy-1-oxo-2-phenylisoquinolin-3-yl)ethyl]carbamoyl]pyrazolo[1,5-a]pyrimidin-2-yl]carbamate	1466565-63-8	C₂₉H₂₈N₆O₅	540.579
——	2-amino-N-[(1S)-1-[1-oxo-2-phenyl-8-(1,3-thiazol-5-yl)isoquinolin-3-yl]ethyl]pyrazolo[1,5-a]pyrimidine-3-carboxamide	1466565-24-1	C₂₇H₂₁N₇O₂S	507.575
——	8-(2-methoxypyrimidin-5-yl)-3-[(1S)-1-[[9-(oxan-2-yl)purin-6-yl]amino]ethyl]-2-phenylisoquinolin-1-one	1350643-67-2	C₃₂H₃₀N₈O₃	574.642

反应信息

作为反应物：

描述：

3-[(1S)-1-氨基乙基]-8-氯-2-苯基-1(2H)-异喹啉酮在盐酸、水、三乙胺作用下，以乙醇、正丁醇为溶剂，反应 17.0h，生成 (S)-3-(1-((9H-嘌呤-6-基)氨基)乙基)-8-氯-2-苯基-1(2H)-异喹啉酮

参考文献：

名称：

[EN] CHEMICAL COMPOUNDS, COMPOSITIONS AND METHODS FOR KINASE MODULATION
[FR] COMPOSÉS CHIMIQUES, COMPOSITIONS ET PROCÉDÉS POUR MODULATION DE KINASES

摘要：

本文描述了调节激酶活性的化合物，包括PI3激酶活性，以及与激酶活性相关的疾病和病况的化合物、药物组合物和治疗方法，包括PI3激酶活性。

公开号：

WO2011146882A1
作为产物：

描述：

(S)-tert-butyl 1-(8-chloro-1-oxo-1H-isochromen-3-yl)ethylcarbamate 在盐酸、三甲基铝作用下，以二氯甲烷、水、异丙醇为溶剂，反应 6.25h，生成 3-[(1S)-1-氨基乙基]-8-氯-2-苯基-1(2H)-异喹啉酮

参考文献：

名称：

[EN] PYRIMIDINE OR PYRIDINE DERIVATIVES USEFUL AS PI3K INHIBITORS
[FR] DÉRIVÉS DE PYRIMIDINE OU DE PYRIDINE UTILES EN TANT QU'INHIBITEURS DE PI3K

摘要：

本文描述了调节激酶活性，包括PI3激酶活性的化合物(I)和药物组合物，以及与激酶活性，包括PI3激酶活性相关的疾病和病状的治疗方法、化合物和药物组合物。

公开号：

WO2015168079A1

点击查看最新优质反应信息

文献信息

[EN] HETEROCYCLIC COMPOUNDS AND USES THEREOF<br/>[FR] COMPOSÉS HÉTÉROCYCLIQUES ET LEURS UTILISATIONS

申请人：INFINITY PHARMACEUTICALS INC

公开号：WO2015051241A1

公开（公告）日：2015-04-09

Compounds and pharmaceutical compositions that modulate kinase activity, including PI3 kinase activity, and compounds, pharmaceutical compositions, and methods of treatment of diseases and conditions associated with kinase activity, including PI3 kinase activity, are described herein.

本发明描述了调节激酶活性的化合物和药物组合物，包括PI3激酶活性，以及用于治疗与激酶活性相关的疾病和状况的化合物、药物组合物和方法，包括PI3激酶活性。
[EN] HETEROCYCLIC COMPOUNDS FOR USE IN THE TREATMENT OF PI3K-GAMMA MEDIATED DISORDERS<br/>[FR] COMPOSÉS HÉTÉROCYCLIQUES DESTINÉS À ÊTRE UTILISÉS DANS LE TRAITEMENT DE TROUBLES MÉDIÉS PAR PI3K-GAMMA

申请人：INFINITY PHARMACEUTICALS INC

公开号：WO2015143012A1

公开（公告）日：2015-09-24

Compounds and pharmaceutical compositions that modulate kinase activity, including PI3 kinase activity, and compounds, pharmaceutical compositions, and methods of treatment of diseases and conditions associated with kinase activity, including PI3 kinase activity, are described herein.

本文描述了调节激酶活性的化合物和药物组合物，包括PI3激酶活性，以及与激酶活性相关的疾病和状况的治疗方法，包括PI3激酶活性的化合物、药物组合物和治疗方法。
HETEROCYCLIC COMPOUNDS AND USES THEREOF

申请人：INFINITY PHARMACEUTICALS, INC.

公开号：US20130267521A1

公开（公告）日：2013-10-10

Compounds and pharmaceutical compositions that modulate kinase activity, including PI3 kinase activity, and compounds, pharmaceutical compositions, and methods of treatment of diseases and conditions associated with kinase activity, including PI3 kinase activity, are described herein.

本发明描述了调节激酶活性的化合物和药物组合物，包括PI3激酶活性，以及用于治疗与激酶活性相关的疾病和状况的化合物、药物组合物和方法，包括PI3激酶活性。
HETEROARYL DERIVATIVE OR PHARMACEUTICALLY ACCEPTABLE SALT THEREOF, PREPARATION METHOD THEREFOR, AND PHARMACEUTICAL COMPOSTION FOR PREVENTING OR TREATING DISEASES ASSOCIATED WITH PI3 KINASES, CONTAINING SAME AS ACTIVE INGREDIENT

申请人：KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY

公开号：US20180105527A1

公开（公告）日：2018-04-19

The present invention relates to a heteroaryl derivative or a pharmaceutically acceptable salt thereof, a preparation method therefor, and a pharmaceutical composition for preventing or treating diseases associated with PI3 kinases, containing the same as an active ingredient. The heteroaryl derivative according to the present invention has an excellent effect of selectively inhibiting PI3 kinases, thereby being useful in preventing or treating PI3 kinase diseases such as: cancers, autoimmune diseases, and respiratory diseases.

本发明涉及一种杂环芳基衍生物或其药用可接受盐，以及其制备方法和包含其作为活性成分的用于预防或治疗与PI3激酶相关疾病的药物组合物。根据本发明的杂环芳基衍生物具有优异的选择性抑制PI3激酶的效果，因此在预防或治疗癌症、自身免疫疾病和呼吸道疾病等PI3激酶疾病方面具有用处。
SUBSTITUTED AMINOPYRIMIDINE COMPOUNDS AND METHODS OF USE

申请人：Xi Ning

公开号：US20190224197A1

公开（公告）日：2019-07-25

The invention relates to the preparation and use of new aminopyrirnidine derivatives as drug candidates in free form or in pharmaceutically acceptable salt form and formulations thereof for the modulation of a disorder or disease which is mediated by the activity of the PI3K enzymes The invention also provides pharmaceutically acceptable compositions comprising such compounds and methods of using the compositions in the treatment of disorders or diseases, such as disorders of immunity and inflammation in which PI3K enzymes play a role in leukocyte function, and hyperproliferative disorders associated with PI3K activity, including but not restricted to leukemias and solid tumors, in mammals, especially humans.

该发明涉及新的氨基吡啶啉衍生物的制备和使用，作为药物候选化合物，可以以自由形式或药用可接受盐形式及其配方用于调节由PI3K酶活性介导的疾病或疾病。该发明还提供包含这些化合物的药用可接受组合物以及使用这些组合物治疗疾病或疾病的方法，例如免疫和炎症障碍，其中PI3K酶在白细胞功能中发挥作用，以及与PI3K活性相关的过度增殖性障碍，包括但不限于哺乳动物，特别是人类中的白血病和实体肿瘤。