methyl 6-[N-ethyl-N-(3-isobutoxy-4-isopropylphenyl)amino]nicotinate | 1055233-46-9

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: methyl 6-[N-ethyl-N-(3-isobutoxy-4-isopropylphenyl)amino]nicotinate
• CAS: 1055233-46-9
• 化学式: C₂₂H₃₀N₂O₃
• 分子量: 370.492
• InChiKey: VNXQWPLWRKNREG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.18
• 重原子数：
  27.0
• 可旋转键数：
  8.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  51.66
• 氢给体数：
  0.0
• 氢受体数：
  5.0

反应信息

• 作为反应物：
  描述：

  methyl 6-[N-ethyl-N-(3-isobutoxy-4-isopropylphenyl)amino]nicotinate 在 碘 、 silver sulfate 作用下， 以 甲醇 为溶剂， 反应 11.0h， 以72%的产率得到methyl 6-[N-ethyl-N-(2-iodo-5-isobutoxy-4-isopropylphenyl)amino]nicotinate
  参考文献：
  名称：

  Discovery of a Potent Retinoid X Receptor Antagonist Structurally Closely Related to RXR Agonist NEt-3IB

  摘要：

  We discovered a potent retinoid X receptor (RXR) antagonist, 6-[N-ethyl-N-(5-isobutoxy-4-isopropyl-2-(E)-styrylphenyl)amino]nicotinic acid (13e), that is structurally closely related to the RXR full agonist 6-[N-ethyl-N-(3-isobutoxy-4-isopropylphenyl)amino]nicotinic acid (NEt-3IB) (4). Compound 13e was synthesized via a simple route from 11, a methyl ester precursor of 4. Because 11 possesses high electrophilic reactivity because of the amino and alkoxy groups, it was readily transformed to 12 by iodization, and the iodine atom of 12 was converted to a C-C or C-N bond by means of palladium-catalyzed reaction to afford 13. Transcriptional activation assay revealed that 13g (in which the iodine atom was replaced with an amino group) is a weak RXR agonist, while 13d (a phenyl group), 13e (a styryl group), and 13f (an anilino group) are RXR antagonists. Among them, 13e was found to be more potent than the known RXR antagonist PA452 (9).

  DOI：

  10.1021/ml200197e
• 作为产物：
  描述：

  2-isobutoxy-1-isopropyl-4-nitrobenzene 在 palladium on activated charcoal 盐酸 、 氢气 、 sodium hydride 、 溶剂黄146 作用下， 以 甲醇 、 N,N-二甲基甲酰胺 为溶剂， 反应 5.17h， 生成 methyl 6-[N-ethyl-N-(3-isobutoxy-4-isopropylphenyl)amino]nicotinate
  参考文献：
  名称：

  REXINOID COMPOUND HAVING ALKOXY GROUP

  摘要：

  公开号：

  EP2116523B1