24-ethyl-coprostanol | 5060-24-2

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: 24-ethyl-coprostanol
• 英文别名: 24α_F-ethyl-5β-cholestanol-(3α)；24α_F-Aethyl-5β-cholestanol-(3α)；3α-Hydroxy-10.13-dimethyl-17β-((1R:4R)-1.5-dimethyl-4-aethyl-hexyl)-5β-gonan；(10S)-3t-Hydroxy-10r.13c-dimethyl-17c-((1R:4R)-1.5-dimethyl-4-aethyl-hexyl)-(5cH.8cH.9tH.14tH)-hexadecahydro-1H-cyclopenta[a]phenanthren；(24R)-24-Aethyl-5β-cholestanol-(3α)；5beta-Stigmastan-3alpha-ol；(3R,5R,8R,9S,10S,13R,14S,17R)-17-[(2R,5R)-5-ethyl-6-methylheptan-2-yl]-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-ol
• CAS: 5060-24-2
• 化学式: C₂₉H₅₂O
• 分子量: 416.731
• InChiKey: LGJMUZUPVCAVPU-MKWLJKGNSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  10.2
• 重原子数：
  30
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  24-ethyl-coprostanol 在 吡啶 、 chromium(VI) oxide 、 乙醚 、 氢溴酸 、 溴 、 溶剂黄146 、 铂 作用下， 生成 24α_F-ethyl-5α-cholestanol-(3α)
  参考文献：
  名称：

  Sterols. XXIV. Sitostenone and Stigmastenone

  摘要：

  DOI：

  10.1021/ja01291a068
• 作为产物：
  描述：

  植物甾醇 在 乙醚 、 铜 、 铂 作用下， 150.0~200.0 ℃ 、266.64 Pa 条件下， 生成 24-ethyl-coprostanol
  参考文献：
  名称：

  Sterols. XXIV. Sitostenone and Stigmastenone

  摘要：

  DOI：

  10.1021/ja01291a068

文献信息

• Sterol derivatives and method of preparing same
  申请人：PARKE DAVIS & CO

  公开号：US02262244A1

  公开（公告）日：1941-11-11
• The Acute Effect of Calcium Carbonate on the Intestinal Absorption of Levothyroxine
  作者：Nalini Singh、Shawna L. Weisler、Jerome M. Hershman

  DOI：10.1089/105072501753211046

  日期：2001.10

  To determine the acute effect of calcium, we measured levothyroxine absorption after ingestion of thyroxine (T4) with and without simultaneous ingestion of calcium (as calcium carbonate) in seven volunteers without thyroid disease. Serum total T-4, total triiodothyronine (T-3), free T-4, and thyrotropin (TSH) levels were measured after ingestion of 1,000 mug of levothyroxine on two separate visits at 4-week intervals: (1) levothyroxine alone and (2) levothyroxine together with 2.0 g of calcium as calcium carbonate. The amount of absorbed levothyroxine was calculated as the incremental rise in serum T-4 level during the first 6 hours multiplied by the volume of distribution for the hormone. When 1,000 mug of levothyroxine alone was given to subjects, the maximum average total T-4 absorption was 837 mug (83.7% of the dose ingested) at 120 minutes. When levothyroxine was coadministered with 2.0 g of calcium (as calcium carbonate), the maximum average T-4 absorption decreased to 579 mug (57.9% of the dose ingested) at 240 minutes. The total levothyroxine absorption over 6 hours was Significantly greater with thyroxine than that with thyroxine and calcium (p = 0.02). The administration of calcium and levothyroxine in these subjects was associated with a significant reduction in the peak increment in serum total T-4 (P = 0.02) and free T-4 levels (p = 0.03), as well as a significant reduction in the overall increment in serum total T-4 (p = 0.003), free T-4 (p = 0.002), and total T-3 levels (p = 0.01) over four time points (120 minutes, 240 minutes, 360 minutes, 1,440 minutes). In summary, this pharmacokinetic study in seven volunteers indicates that calcium carbonate acutely reduces T-4 absorption.
• Dirscherl; Kraus, Hoppe-Seyler's Zeitschrift fur Physiologische Chemie, 1938, vol. 253, p. 64,70
  作者：Dirscherl、Kraus

  DOI：——

  日期：——
• Sterols. XXV. The Allostigmasterols and Allositosterols
  作者：Russell E. Marker、Thomas S. Oakwood

  DOI：10.1021/ja01291a069

  日期：1937.12
• Sterols. XXIV. Sitostenone and Stigmastenone
  作者：Russell E. Marker、Eugene L. Wittle

  DOI：10.1021/ja01291a068

  日期：1937.12