5-羟基-4H-萘并[2,3-f]喹啉-6,7,12-三酮 | 568-02-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 蒽
• 中文名称: 5-羟基-4H-萘并[2,3-f]喹啉-6,7,12-三酮
• 英文名称: alizarine Blue
• 英文别名: Alizarin blue；5,6-dihydroxy-naphtho[2,3-f]quinoline-7,12-dione；5,6-Dihydroxy-naphtho[2,3-f]chinolin-7,12-dion；Alizarinblau；5-Hydroxynaphtho[2,3-f]quinoline-6,7,12(4H)-trione；5,6-dihydroxynaphtho[2,3-f]quinoline-7,12-dione
• CAS: 568-02-5
• 化学式: C₁₇H₉NO₄
• 分子量: 291.263
• InChiKey: JROURLWMOZCGJV-UHFFFAOYSA-N

物化性质

• 熔点：
  268-270°
• 沸点：
  433.27°C (rough estimate)
• 密度：
  1.2442 (rough estimate)

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  22
• 可旋转键数：
  0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  87.5
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  5-羟基-4H-萘并[2,3-f]喹啉-6,7,12-三酮 在 硫酸 作用下， 生成 5,6,11-trihydroxy-7,12-dioxo-7,12-dihydro-naphtho[2,3-f]quinoline-8-sulfonic acid
  参考文献：
  名称：

  Schmidt,R.; Gattermann, Journal fur praktische Chemie (Leipzig 1954), 1891, vol. <2> 44, p. 105

  摘要：

  DOI：
• 作为产物：
  描述：

  naphtho[2,3-f]quinoline-5,6,7,12-tetraone 、 alkaline earth salt of/the/ methylsulfuric acid 生成 5-羟基-4H-萘并[2,3-f]喹啉-6,7,12-三酮
  参考文献：
  名称：

  DE171836

  摘要：

  公开号：

文献信息

• Neutral and positively charged dyes for electrophoresis sample loading solutions
  申请人：E.I. DU PONT DE NEMOURS AND COMPANY

  公开号：EP0464544A1

  公开（公告）日：1992-01-08

  A method of electrophoretically separating bioorganic molecules is disclosed. The method uses a slab electrophoresis gel and positively or neutrally charged dyes to prevent the dyes from interfering with the gel readout.

  本发明公开了一种电泳分离生物有机分子的方法。该方法使用板式电泳凝胶和带正电或中性电荷的染料，以防止染料干扰凝胶读数。
• Polymer scale preventive agent, polymerization vessel for preventing polymer scale deposition, and process of producing polymer using said vessel
  申请人：SHIN-ETSU CHEMICAL CO., LTD.

  公开号：EP0482593A1

  公开（公告）日：1992-04-29

  A polymer scale preventive agent for use in polymerization of a monomer having an ethylenic double bond, comprising (A) a nitrogen-containing organic compound having at least five continuous conjugated π bonds, (B) an anionic organic compound having at least one group selected from the group consisting of the sulfonic acid group and the carboxylic group and having at least five continuous conjugated π bonds, and (C) a vinylpyrrolidone-based polymer. The agent is used for forming a coating on the inner wall, etc. of a polymerization vessel. Deposition of polymer scale can be effectively prevented not only in the liquid phase area but also in the vicinity of the interface between the gas and liquid phases. Products formed from polymer obtained have very few fish eyes.

  一种聚合物防垢剂，用于具有乙烯双键的单体的聚合，包括：(A) 至少具有五个连续共轭 π 键的含氮有机化合物；(B) 至少具有一个从磺酸基和羧酸基组成的组中选出的基团且至少具有五个连续共轭 π 键的阴离子有机化合物；以及 (C) 乙烯基吡咯烷酮基聚合物。该剂用于在聚合容器的内壁等处形成涂层。不仅在液相区域，而且在气相和液相界面附近都能有效防止聚合物垢的沉积。由聚合物形成的产品很少有鱼眼。
• 5-GLYCOSYLOXY-6-HYDROXYNAPHTHO 2,3-f]QUINOLINE-7,12-DIONE HAVING ANTICANCER ACTIVITIES
  申请人：ZAIDAN HOJIN BISEIBUTSU KAGAKU KENKYU KAI

  公开号：EP1156056A1

  公开（公告）日：2001-11-21

  As novel compounds which exhibit reduced toxicities but enhanced anticancer activities in comparison with those of known carcinostatic anthracycline derivatives, there is provided a compound of general formula (I) wherein A is methyl group or CF3 group, and B is hydrogen atom, or an electron-withdrawing group chosen from halogeno group and others, provided that B stands for hydrogen atom when A is CF3 and that B stands for an electron-withdrawing group when A is methyl group, and R1 and R2 each are hydroxyl group, amino group or an acyloxy group or an aminoalkanoyloxy group, and others, or a pharmaceutically acceptable salt thereof. The compound of general formula (I) possesses activities inhibitory to proliferation of various human cancer cells and is of lower toxicity than that of adriamycin. Further, there is provided, as novel and water-soluble carcinostatic compounds, a compound of general formula (V) wherein A and B have the same meanings as defined above, and R5 is hydrogen atom or an ω-amino acid residue, and R6 and R7 have the same meanings as defined for R5, provided that R5, R6 and R7 do not represent hydrogen atom, simultaneously.

  作为新型化合物，与已知的致癌性蒽环类衍生物相比，其毒性降低，但抗癌活性增强，现提供通式（I）的化合物 其中 A 为甲基或 CF3 基团，B 为氢原子或从卤代基团及其他基团中选出的抽电子基团，但 A 为 CF3 时 B 代表氢原子，A 为甲基时 B 代表抽电子基团，R1 和 R2 分别为羟基、氨基或酰氧基或氨基烷酰氧基及其他基团，或其药学上可接受的盐。通式（I）化合物具有抑制各种人类癌细胞增殖的活性，其毒性低于阿霉素。 此外，还提供了通式（V）化合物，作为新型水溶性抗癌化合物 其中 A 和 B 的含义与上述定义相同，R5 为氢原子或ω-氨基酸残基，R6 和 R7 的含义与 R5 的定义相同，但 R5、R6 和 R7 同时不代表氢原子。
• Accelerators for increasing the rate of formation of free radicals and reactive oxygen species
  申请人：Cavalier Discovery

  公开号：US20030082101A1

  公开（公告）日：2003-05-01

  The formation of free radicals is enhanced with photodynamic agents, sonodynamic agents, and systems and therapies utilizing ultrasound by subjecting the agent to light waves or sound waves in the presence of a metal, a reductant, or a chelate, or mixtures thereof.

  光动力药剂、声动力药剂以及利用超声波的系统和疗法，在有金属、还原剂或螯合物或它们的混合物存在的情况下，使药剂受到光波或声波的作用，可促进自由基的形成。
• Method of making a laundry detergent article containing detergent formulations
  申请人：NewLund Laboratories, Inc.

  公开号：US20030207630A1

  公开（公告）日：2003-11-06

  A laundry sheet is disclosed which is a substrate having a laundry detergent applied thereto. The laundry detergent readily solubilizes off of the substrate sheet during the washing process to provide a total laundering process that cleans and softens. Also disclosed are several laundry detergent formulations which are preferably applied onto the substrate to make the laundry sheet of the present invention and a process for making the laundry sheet.

  本发明公开了一种洗衣片，它是一种涂有洗衣粉的基材。在洗涤过程中，洗衣粉很容易从基材片材上溶解下来，从而提供一个清洁和柔软的整体洗涤过程。此外，本发明还公开了几种洗衣粉配方，这些配方最好涂在基材上，以制成本发明的洗衣片，并公开了制造洗衣片的工艺。