N'-methyl-N,N''-bis(diisopropyl)diethylenetriamine | 211384-00-8

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: N'-methyl-N,N''-bis(diisopropyl)diethylenetriamine
• 英文别名: N'-methyl-N-propan-2-yl-N'-[2-(propan-2-ylamino)ethyl]ethane-1,2-diamine
• CAS: 211384-00-8
• 化学式: C₁₁H₂₇N₃
• 分子量: 201.355
• InChiKey: MIKZHRLAZWYRCK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  14
• 可旋转键数：
  8
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  27.3
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  N'-methyl-N,N''-bis(diisopropyl)diethylenetriamine 在 BuLi 作用下， 以 四氢呋喃 、 乙醚 、 正己烷 、 甲苯 为溶剂， 生成 [[(i-PrNHCH2CH2)(i-PrNCH2CH2)NMe]AlCl][AlCl4]
  参考文献：
  名称：

  具有三齿氮供体的中性和阳离子四配位铝配合物：环氧丙烷和（d，l）-丙交酯开环聚合的合成，结构和催化活性

  摘要：

  N，N '，N ''-三（三甲基甲硅烷基）二亚乙基三胺（1），N-甲基-N '，N ''-双（三甲基甲硅烷基）二亚乙基三胺（2）和N-甲基-N '的二锂盐，N ''-双（二异丙基）二亚乙基三胺（3）在-40°C下于THF中与AlCl 3反应，得到单体氯化铝衍生物4（55％的收率），5（76％的收率）和6（71％的收率） ）， 分别。将1当量的AlMe 3加到胺2中得到五配位的二甲基铝衍生物9（产率67％）；在80°C下将9的甲苯溶液加热过夜会引起甲烷的损失，从而生成四配位的甲基铝化合物10（收率50％）。胺2还在低温下与LiAlH 4反应，得到衍生物11（38％收率）。化合物4 - 6在甲苯中反应，随后用1个当量盐酸和氯化铝的1个当量3，得到第一手性四配铝阳离子12（94％产率），13（93％产率），和14（收率90％）。单晶衍生物的X射线衍射研究4，5，8，10，11，12，和15已经进

  DOI：

  10.1021/om980401b
• 作为产物：
  描述：

  N-甲基二乙醇胺 在 氯化亚砜 作用下， 以 氯仿 、 水 为溶剂， 反应 10.0h， 生成 N'-methyl-N,N''-bis(diisopropyl)diethylenetriamine
  参考文献：
  名称：

  TIN COMPOUND, TIN PRECURSOR COMPOUND FOR FORMING A TIN-CONTAINING LAYER, AND METHODS OF FORMING A THIN LAYER USING THE SAME

  摘要：

  一种锡化合物、一种形成含锡层的锡前体化合物以及一种形成薄层的方法，其中该锡化合物由式1表示：其中R1、R2、R3、R4、R5、R6和R7各自独立地表示氢、具有1至4个碳原子的线性烷基或具有3或4个碳原子的支链烷基。

  公开号：

  US20200231610A1

文献信息

• A Remarkable Switch from a Diamination to a Hydrohydrazination Catalyst and Observation of an Unprecedented Catalyst Resting State
  作者：Andrew D. Schwarz、Chee S. Onn、Philip Mountford

  DOI：10.1002/anie.201206249

  日期：2012.12.3

  alkynes gave the unusual acetylide–vinylhydrazide(1−) compounds 2 (R=4‐C6H4X (X=Me, CF3, OMe), C6F5, SiMe3) as hydrohydrazination intermediates. In contrast, a complex similar to 1 with bulkier trimethylsilyl substituents in place of the isopropyl groups is known to catalyze the 1,2‐diamination of alkynes with hydrazines.

  很小的变化带来的巨大影响：钛配合物1与末端炔烃的反应产生了不寻常的乙炔-乙烯基酰肼（1-）化合物2（R = 4-C 6 H 4 X（X = Me，CF 3，OMe）， C 6 F 5，SiMe 3）作为氢化肼化中间体。相反，已知一种类似于1的配合物，具有更大的三甲基甲硅烷基取代基来代替异丙基，可以催化炔类与肼的1,2-重整反应。
• METAL TRIAMINE COMPOUND, METHOD FOR PREPARING SAME, AND COMPOSITION CONTAINING SAME FOR DEPOSITING METAL-CONTAINING THIN FILM
  申请人：Dnf Co., Ltd.

  公开号：EP3434683A1

  公开（公告）日：2019-01-30

  Provided are a novel metal triamine compound, a method for preparing the same, a composition for depositing a metal-containing thin film including the same, and a method for preparing a metal-containing thin film using the same. The metal triamine compound of the present invention has excellent reactivity, is thermally stable, has high volatility, and has high storage stability, and thus, it may be used as a metal-containing precursor to easily prepare a high-purity metal-containing thin film having high density.

  本发明提供了一种新型金属三胺化合物、一种制备该化合物的方法、一种包括该化合物的沉积含金属薄膜的组合物，以及一种使用该化合物制备含金属薄膜的方法。本发明的金属三胺化合物具有优异的反应活性、热稳定性、高挥发性和高储存稳定性，因此可用作含金属前体，轻松制备具有高密度的高纯度含金属薄膜。
• Eight-arm polyethylene glycol derivative, production method therefor, and modified bio-related substance thereof
  申请人：XIAMEN SINOPEG BIOTECH CO., LTD.

  公开号：US10434182B2

  公开（公告）日：2019-10-08

  Disclosed are an eight-arm polyethylene glycol (PEG) derivative (formula I), production method therefor and modified bio-related substance thereby. Wherein, one tetravalent group U together with four trivalent groups Ec form a highly symmetrical octavalent group CORE0; Lc connects the octavalent group to eight PEG chains having polydispersity or monodispersity and having n1 to n8 as the degree of polymerization thereof; the terminal of one PEG chain is connected to at least one functional group F (k≥1); said PEG chain and F therebetween can be directly connected (g=0) or be indirectly connected via a linking group L0 to a terminal end-branching group G (g=1); the latter provides more reactive sites for binding more drug molecules and increases the drug loading. The eight-arm polyethylene glycol derivative has a centrosymmetric or approximately centrosymmetric structure, and leads to more precise control of the molecular weight in large-scale production and much narrower distribution of molecular weight for products. The modified bio-related substance thereby has a more uniform and controllable performance.

  本发明公开了一种八臂聚乙二醇（PEG）衍生物（式 I）、其生产方法及其改性生物相关物质。其中，一个四价基团 U 与四个三价基团 Ec 形成一个高度对称的八价基团 CORE0；Lc 将八价基团连接到八条具有多分散性或单分散性且聚合度为 n1 至 n8 的 PEG 链上；一条 PEG 链的末端与至少一个官能团 F 连接（k≥1）；所述 PEG 链和 F 之间可以直接连接（g=0），也可以通过连接基团 L0 与末端支化基团 G 间接连接（g=1）；后者提供了更多的反应位点，可以结合更多的药物分子，增加药物负载量。八臂聚乙二醇衍生物具有中心对称或近似中心对称结构，因此在大规模生产中可以更精确地控制分子量，产品的分子量分布也更窄。因此，改性生物相关物质的性能更均匀、更可控。
• EIGHT-ARM POLYETHYLENE GLYCOL DERIVATIVE, PRODUCTION METHOD THEREFOR, AND MODIFIEDBIO-RELATEDSUBSTANCETHEREOF
  申请人：XIAMEN SINOPEG BIOTECH CO., LTD

  公开号：US20180214561A1

  公开（公告）日：2018-08-02

  Disclosed are an eight-arm polyethylene glycol (PEG) derivative (formula I), production method therefor and modified bio-related substance thereby. Wherein, one tetravalent group U together with four trivalent groups E c form a highly symmetrical octavalent group CORE 0 ; L c connects the octavalent group to eight PEG chains having polydispersity or monodispersity and having n 1 to n 8 as the degree of polymerization thereof; the terminal of one PEG chain is connected to at least one functional group F (k≥1); said PEG chain and F therebetween can be directly connected (g=0) or be indirectly connected via a linking group L 0 to a terminal end-branching group G (g=1); the latter provides more reactive sites for binding more drug molecules and increases the drug loading. The eight-arm polyethylene glycol derivative has a centrosymmetric or approximately centrosymmetric structure, and leads to more precise control of the molecular weight in large-scale production and much narrower distribution of molecular weight for products. The modified bio-related substance thereby has a more uniform and controllable performance.
• METAL TRIAMINE COMPOUND, METHOD FOR PREPARING THE SAME, AND COMPOSITION FOR DEPOSITING METAL-CONTAINING THIN FILM INCLUDING THE SAME
  申请人：DNF CO., LTD.

  公开号：US20210222294A1

  公开（公告）日：2021-07-22

  Provided are a novel metal triamine compound, a method for preparing the same, a composition for depositing a metal-containing thin film including the same, and a method for preparing a metal-containing thin film using the same. The metal triamine compound of the present invention has excellent reactivity, is thermally stable, has high volatility, and has high storage stability, and thus, it may be used as a metal-containing precursor to easily prepare a high-purity metal-containing thin film having high density.