氨基亚丙基二膦酸 | 15049-86-2

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机膦酸及其衍生物
• 中文名称: 氨基亚丙基二膦酸
• 英文名称: 1-Aminopropan-1,1-diphosphonsaeure
• 英文别名: [(1S)-1-azaniumyl-1-phosphonopropyl]-hydroxyphosphinate
• CAS: 15049-86-2
• 化学式: C₃H₁₁NO₆P₂
• 分子量: 219.071
• InChiKey: PCTMREJZUSEOQD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -5.7
• 重原子数：
  12
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  141
• 氢给体数：
  5
• 氢受体数：
  7

安全信息

• 储存条件：
  室温

反应信息

• 作为反应物：
  描述：

  氨基亚丙基二膦酸 在 sodium hydroxide 、 乙酸酐 作用下， 以 水 为溶剂， 以88%的产率得到monosodium salt of N-acetyl-1-amino propane-1,1-diphosphonic acid
  参考文献：
  名称：

  N-acyl-1-amino alkane-1,1-diphosphonic acid compounds, process of making

  摘要：

  N-酰基-1-氨基烷基-1,1-二膦酸或其碱金属盐是高效的防垢剂、金属离子络合剂、螯合剂和防腐剂，可在清洗液和洗涤剂制备中得到极大的优势应用。这种N-酰基-1-氨基烷基-1,1-二膦酸可以通过酰化相应的1-氨基烷基-1,1-二膦酸或水解相应的(1,1-二膦酸烷基)酰胺得到。

  公开号：

  US04029697A1
• 作为产物：
  描述：

  丙腈 在 亚磷酸 作用下， 反应 12.0h， 以70%的产率得到氨基亚丙基二膦酸
  参考文献：
  名称：

  Synthesis and biological evaluation of 1-amino-1,1-bisphosphonates derived from fatty acids against Trypanosoma cruzi targeting farnesyl pyrophosphate synthase

  摘要：

  We have investigated the effect of a series of 1-amino-1,1-bisphosphonates derived from fatty acids against proliferation of the clinically more relevant form of Trypanosoma cruzi, the causative agent of American trypanosomiasis (Chagas' disease). Some of these drugs were potent inhibitors against the intracellular form of the parasite, exhibiting IC50 values at low micromolar level. Cellular activity was associated with the inhibition of enzymatic activity of T cruzi farnesyl pyrophosphate synthase. As bisphosphonate-containing drugs are FDA-approved for the treatment of bone resorption disorders, their potential innocuousness makes them good candidates to control tropical diseases. (c) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2005.07.060

文献信息

• N-Sulfo alkane amino alkane phosphoric acids and their alkali metal
  申请人：Benckiser-Knapsack GmbH

  公开号：US04216163A1

  公开（公告）日：1980-08-05

  Novel and highly advantageous N-sulfo alkane amino alkane phosphonic acids and their alkali metal salts are provided. Said phosphonic acids are produced by reacting an alkali metal salt of an amino phosphonic acid with a halo, preferably chloro, or hydroxy alkane sulfonic acid or their alkali metal salts in an alkaline medium, while heating. In place of the halo and especially chloro or hydroxy alkane sulfonic acid reactants, there can also be used compounds which are capable of producing hydroxy alkane sulfonates such as carbylsulfate or aldehydes or, respectively, ethylene oxide with alkali metal bisulfites or metasulfites. The reaction is preferably carried out in a molar proportion of about 1:1 to about 1:2. The novel compounds are excellent complexing or sequestering agents especially with respect to polyvalent metal ions. They are highly resistant against hydrolysis and high temperatures and are of a very high water solubility.

  提供了新颖且高效的N-磺酸烷基氨基磷酸和其碱金属盐。所述磷酸是通过将氨基磷酸的碱金属盐与卤素（优选氯）或羟基烷基磺酸或它们的碱金属盐在碱性介质中反应，并加热而制备的。在卤素，特别是氯或羟基烷基磺酸的反应物的位置，也可以使用能够产生羟基烷基磺酸盐的化合物，如羧酸酯或醛类，或分别与碱金属亚硫酸氢盐或亚硫酸盐反应的乙烯氧化物。反应最好在摩尔比约为1:1至约为1:2的比例下进行。这些新颖的化合物是优秀的络合或螯合剂，特别是对于多价金属离子。它们对水解和高温具有很高的抵抗力，并且具有非常高的水溶性。
• Method of preparing phosphonates from nitriles
  申请人：Magna Corporation

  公开号：US04239695A1

  公开（公告）日：1980-12-16

  Amino-phosphonates typified by the general formula R--C(PO(OH).sub.2).sub.2 NH.sub.2 are prepared by reacting phosphorous acid with nitriles at elevated temperatures.

  以一般公式 R--C(PO(OH).sub.2).sub.2 NH.sub.2 为代表的氨基膦酸盐是通过在高温下将腈与磷酸反应制备的。
• N-Carboxy alkyl amino alkane polyphosphonic acids
  申请人：Benckiser-Knapsack GmbH

  公开号：US04307038A1

  公开（公告）日：1981-12-22

  Novel N-carboxy alkyl amino alkane polyphosphonic acids which have more than two carbon atoms in their carboxy alkyl group, and their alkali metal salts are prepared in a good yield by reacting alkali metal salts of amino alkane phosphonic acids in which at least one hydrogen atom of the amino group is unsubstituted, in an alkaline medium with an .alpha., .beta.-unsaturated carboxylic acid at increased temperature. The free acids are preferably recovered from the reaction solution by a treatment with a cation exchange agent. In place of the .alpha., .beta.-unsaturated carboxylic acids there can also be used their anhydrides, esters, or nitriles. The resulting polyphosphonic acids have a good complexing or sequestering effect on polyvalent metal ions.

  通过在碱性介质中将至少一个氨基中的氢原子未取代的氨基烷膦酸盐与α，β-不饱和羧酸在升高的温度下反应，可以高产地制备具有其羧基烷基中有两个以上碳原子的N-羧基烷基氨基烷多聚膦酸及其碱金属盐。可以通过使用阴离子交换剂从反应溶液中回收自由酸。在α，β-不饱和羧酸的位置上，也可以使用它们的酐，酯或腈。所得的多聚膦酸对多价金属离子具有良好的络合或螯合作用。
• Composition and treating aqueous solutions with N-carboxy alkyl amino
  申请人：Benckiser-Knapsack GmbH

  公开号：US04308147A1

  公开（公告）日：1981-12-29

  Disclosed are a composition and method for treating aqueous solutions with N-carboxy alkyl amino alkane polyphosphonic acids which have more than two carbon atoms in their carboxy alkyl group, and their alkali metal salts. The acids and salts are prepared in a good yield by reacting alkali metal salts of amino alkane phosphonic acids in which at least one hydrogen atom of the amino group is unsubstituted, in an alkaline medium with an .alpha.,.beta.-unsaturated carboxylic acid at increased temperature. The free acids are preferably recovered from the reaction solution by a treatment with a cation exchange agent. In place of the .alpha.,.beta.-unsaturated carboxylic acids there can also be used their anhydrides, esters, or nitriles. The resulting polyphosphonic acids have a good complexing or sequestering effect on polyvalent metal ions.

  本发明涉及使用具有两个以上碳原子的N-羧基烷基氨基烷聚磷酸酸及其碱金属盐处理水溶液的组合物和方法。通过在碱性介质中将至少一个氨基的氢原子未取代的氨基磷酸盐与α，β-不饱和羧酸在升高的温度下反应，可以高产率地制备酸和盐。最好使用阳离子交换剂从反应溶液中回收自由酸。除了α，β-不饱和羧酸外，还可以使用它们的酸酐，酯或腈。所得的聚磷酸酸对多价金属离子具有良好的络合或螯合作用。
• Production of 1-aminoalkane-1, 1-diphosphonic acids using phosphorous
  申请人：Nalco Chemical Company

  公开号：US04100167A1

  公开（公告）日：1978-07-11

  1-aminoalkane--1, 1-diphosphonic acids of the formula, ##STR1## may be produced in good yield by reacting a nitrile of the formula, R -- CH.sub.2 -- C .tbd. N with at least 2 moles of phosphorous acid in the presence of a high boiling hydrocarbon oil at a temperature ranging between 140.degree.-170.degree. C without a catalyst. In the above formula, R is hydrogen, alkyl, aryl, arylalkyl, substituted aryl, substituted alkyl, and substituted arylalkyl. These compounds show anti-corrosive activity.

  公式为##STR1##的1-氨基烷基-1,1-二膦酸盐可以通过在高沸点烃油存在下，在温度在140℃至170℃之间的条件下，将公式为R-CH2-C≡N的腈与至少2摩尔的磷酸反应而获得良好的产率，反应无需催化剂。在上述公式中，R为氢、烷基、芳基、芳基烷基、取代芳基、取代烷基和取代芳基烷基。这些化合物表现出防腐蚀活性。