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triphenyl(carbethoxymethyl)phosphonium bromide | 4083-85-6

中文名称
——
中文别名
——
英文名称
triphenyl(carbethoxymethyl)phosphonium bromide
英文别名
ethyl 2-(bromotriphenylphosphoranyl)acetate;carboethoxytriphenylphosphoniumbromide;Ethyl 2-(bromotriphenyl-l5-phosphanyl)acetate;ethyl 2-[bromo(triphenyl)-λ5-phosphanyl]acetate
triphenyl(carbethoxymethyl)phosphonium bromide化学式
CAS
4083-85-6
化学式
C22H22BrO2P
mdl
——
分子量
429.293
InChiKey
UYMZZYLECILSGL-UHFFFAOYSA-N
BEILSTEIN
——
EINECS
——
  • 物化性质
  • 计算性质
  • ADMET
  • 安全信息
  • SDS
  • 制备方法与用途
  • 上下游信息
  • 反应信息
  • 文献信息
  • 表征谱图
  • 同类化合物
  • 相关功能分类
  • 相关结构分类

物化性质

  • 熔点:
    152-153 °C

计算性质

  • 辛醇/水分配系数(LogP):
    5.9
  • 重原子数:
    26
  • 可旋转键数:
    7
  • 环数:
    3.0
  • sp3杂化的碳原子比例:
    0.14
  • 拓扑面积:
    26.3
  • 氢给体数:
    0
  • 氢受体数:
    2

安全信息

  • 危险性防范说明:
    P261,P305+P351+P338
  • 危险性描述:
    H315,H319,H335
  • 储存条件:
    室温

SDS

SDS:039187dd46cbd5e2dcbed7470ee43573
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上下游信息

  • 下游产品
    中文名称 英文名称 CAS号 化学式 分子量

反应信息

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文献信息

  • Amino acid amides of piperic acid (PA) and 4-ethylpiperic acid (EPA) as NorA efflux pump inhibitors of Staphylococcus aureus
    作者:Naiem Ahmad Wani、Samsher Singh、Saleem Farooq、Sudha Shankar、Surrinder Koul、Inshad Ali Khan、Rajkishor Rai
    DOI:10.1016/j.bmcl.2016.07.062
    日期:2016.9
    A total of eighteen piperic acid (PA) and 4-ethylpiperic acid (EPA) amides (C1-C18) with α-, β- and γ-amino acids were synthesized, characterized and evaluated for their efflux pump inhibitory activity against ciprofloxacin resistant Staphylococcus aureus. The amides were screened against NorA overexpressing S. aureus SA-1199B and wild type S. aureus SA-1199 using ethidium bromide as NorA efflux pump
    合成了总共18种带有α-,β-和γ-氨基酸的哌酸(PA)和4-乙基哌酸(EPA)酰胺(C1-C18),表征并评估了其对耐环丙沙星葡萄球菌的外排泵抑制活性金黄色的。使用溴化乙锭作为NorA外排泵底物,针对过表达NorA的过表达金黄色葡萄球菌SA-1199B和野生型金黄色葡萄球菌SA-1199筛选酰胺。发现EPI C6最有效,环丙沙星的MIC降低了16倍,其次是C18,MIC降低了4倍。溴化乙锭的流出抑制和蓄积分析证明了这些化合物是NorA抑制剂。
  • Study of IspH, a Key Enzyme in the Methylerythritol Phosphate Pathway Using Fluoro-Substituted Substrate Analogues
    作者:Youli Xiao、Wei-chen Chang、Hung-wen Liu、Pinghua Liu
    DOI:10.1021/ol202559r
    日期:2011.11.4
    IspH, a [4Fe-4S]-cluster-containing enzyme, catalyzes the reductive dehydroxylation of 4-hydroxy-3-methyl-butenyl diphosphate (HMBPP) to isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) in the methylerythritol phosphate pathway. Studies of IspH using fluoro-substituted substrate analogues to dissect the contributions of several factors to IspH catalysis, including the coordination
    IspH 是一种含 [4Fe-4S] 簇的酶,可在甲基赤藓糖醇磷酸酯途径中催化 4-羟基-3-甲基-丁烯基二磷酸 (HMBPP) 还原脱羟基为异戊烯二磷酸 (IPP) 和二甲基烯丙基二磷酸 (DMAPP)。使用氟取代底物类似物对 IspH 进行研究,以剖析几个因素对 IspH 催化的贡献,包括 HMBPP C 4 –OH 基团与铁硫簇的配位、活性位点中的 H 键网络以及报道了基板的电子特性。
  • Prophylactic/Therapeutic Agent for Diabetes
    申请人:Cho Nobuo
    公开号:US20090264650A1
    公开(公告)日:2009-10-22
    The present invention relates to a 11β-hydroxysteroid dehydrogenase 1 inhibitor comprising a compound represented by the formula (1): wherein each symbol is as defined in the description, or a salt thereof, or a prodrug thereof. The 11β-hydroxysteroid dehydrogenase 1 inhibitor of the present invention has a superior activity, and is useful as a pharmaceutical agent such as agents for the prophylaxis or treatment of diabetes, insulin resistance, obesity, abnormal lipid metabolism, hypertension and the like, and the like.
    本发明涉及一种11β-羟基类固醇脱氢酶1抑制剂,其包括由式(1)表示的化合物,其中每个符号如描述中所定义的,或其盐或前药。本发明的11β-羟基类固醇脱氢酶1抑制剂具有优异的活性,可用作药物剂,如用于预防或治疗糖尿病、胰岛素抵抗、肥胖症、异常脂质代谢、高血压等的药剂。
  • PROPHYLACTIC/THERAPEUTIC AGENT FOR DIABETES
    申请人:Takeda Pharmaceutical Company Limited
    公开号:EP1864971A1
    公开(公告)日:2007-12-12
    The present invention relates to a 11β-hydroxysteroid dehydrogenase 1 inhibitor comprising a compound represented by the formula (1): wherein each symbol is as defined in the description, or a salt thereof, or a prodrug thereof. The 11β-hydroxysteroid dehydrogenase 1 inhibitor of the present invention has a superior activity, and is useful as a pharmaceutical agent such as agents for the prophylaxis or treatment of diabetes, insulin resistance, obesity, abnormal lipid metabolism, hypertension and the like, and the like.
    本发明涉及一种 11β-羟基类固醇脱氢酶 1 抑制剂,由式(1)代表的化合物组成: 其中各符号如说明中所定义,或其盐,或其原药。本发明的11β-羟类固醇脱氢酶1抑制剂具有优异的活性,可作为药物制剂,如用于预防或治疗糖尿病、胰岛素抵抗、肥胖、脂代谢异常、高血压等疾病的药物。
  • Strong Bicyclic Guanidine Base-Promoted Wittig and Horner−Wadsworth−Emmons Reactions
    作者:Daniele Simoni、Marcello Rossi、Riccardo Rondanin、Angelica Mazzali、Riccardo Baruchello、Cinzia Malagutti、Marinella Roberti、Francesco Paolo Invidiata
    DOI:10.1021/ol0001665
    日期:2000.11.1
    [GRAPHICS]A convenient procedure to effect the Wittig and Horner-Wadsworth-Emmons reactions employs guanidine TBD and MTBD as base-promoters; mild reaction conditions, high efficiency, and facile isolation of the final products make the present methodology, at least in some cases, a practical alternative to known procedures.
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