苯乙酸（银盐） | 35363-48-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 苯乙酸（银盐）
• 英文名称: Phenylessigsaeure-silbersalz
• 英文别名: Silbersalz von Phenylessigsaeure；phenyl-acetic acid ; silver (I)-compound；Phenyl-essigsaeure; Silber(I)-Verbindung；silver phenyl acetate；Silver;2-phenylacetate
• CAS: 35363-48-5
• 化学式: Ag*C₈H₇O₂
• 分子量: 243.011
• InChiKey: YCPUVKXPVYSBAJ-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  -0.02
• 重原子数：
  11
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  40.1
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  苯乙酸（银盐） 在 亚硝酰氯 作用下， 生成 Phenacetylnitrit
  参考文献：
  名称：

  Pritzkow,W.; Nitzer,H., Journal fur praktische Chemie (Leipzig 1954), 1964, vol. 25, p. 69 - 78

  摘要：

  DOI：

文献信息

• [EN] METHODS OF MAKING L-ORNITHINE PHENYL ACETATE<br/>[FR] PROCÉDÉS DE FABRICATION D'ACÉTATE DE PHÉNYLE DE L-ORNITHINE
  申请人：OCERA THERAPEUTICS INC

  公开号：WO2012048043A1

  公开（公告）日：2012-04-12

  Disclosed herein are processes for making L-ornithine phenyl acetate. The process may include, for example, intermixing a halide salt of L-ornithine with silver phenyl acetate. The process may also include forming a phenyl acetate salt in situ. The present application also relates to various compositions obtained from these processes, including crystalline forms.

  本文披露了制备L-鸟氨酸苯乙酸盐的过程。该过程可能包括将L-鸟氨酸的卤化盐与苯乙酸银进行混合。该过程还可能包括在原位形成苯乙酸盐。本申请还涉及从这些过程中获得的各种组合物，包括结晶形式。
• [EN] L-ORNITHINE PHENYL ACETATE AND METHODS OF MAKING THEREOF<br/>[FR] ACÉTATE DE PHÉNYLE L-ORNITHINE ET SES PROCÉDÉS DE FABRICATION
  申请人：OCERA THERAPEUTICS INC

  公开号：WO2010115055A1

  公开（公告）日：2010-10-07

  Disclosed herein are crystalline forms of L-ornithine phenyl acetate and methods of making the same. The crystalline form may, in some embodiments, be Forms I, II, III and V, or mixtures thereof. The crystalline forms may be formulated for treating subjects with liver disorders, such as hepatic encephalopathy. Accordingly, some embodiments include formulations and methods of administering L-ornithine phenyl acetate.

  本文披露了L-鸟氨酸苯乙酸的晶型及其制备方法。在某些实施例中，晶型可能是I、II、III和V形式，或其混合物。这些晶型可以用于治疗患有肝脏疾病如肝性脑病的患者。因此，某些实施例包括L-鸟氨酸苯乙酸的配方和给药方法。
• Novel developing agents for (photo) thermographic systems
  申请人：MINNESOTA MINING AND MANUFACTURING COMPANY

  公开号：EP0681210A1

  公开（公告）日：1995-11-08

  A thermographic element comprising in a non-aqueous binder medium a silver salt oxidising agent in reactive association with a compound comprising a plurality of redox colour releasing moieties such that oxidation of each redox colour releasing moiety causes release from said compound of a thermally diffusible dye. The compounds many of which are new incorporate two or more developer moieties into a single molecule to minimise the diffusibility of the compound. Following oxidation, either directly by the silver salt or by means of a cross-oxidising agent, each oxidised developer moiety releases a thermally diffusible dye. The compounds are of sufficient size and molecular weight to slow or prevent diffusion in imaging systems and yet possess several active developer moieties per molecule which is advantageous over known ballasted dye releasers which comprise bulky molecules with only a single developer moiety.

  一种热成像元素，包括在非水性粘合剂介质中，一种银盐氧化剂与含有多个氧化还原色释放基团的化合物反应地结合，使得每个氧化还原色释放基团的氧化引起所述化合物中的热扩散染料的释放。这些化合物中的许多是新的，将两个或更多的显影剂基团结合到一个分子中，以减少化合物的扩散性。在氧化后，通过银盐直接氧化或通过交叉氧化剂，每个氧化的显影剂基团释放出一个热扩散染料。这些化合物足够大且具有足够的分子量，以在成像系统中减慢或阻止扩散，但每个分子中具有多个活性显影剂基团，这比已知的只包含单个显影剂基团的笨重分子的配重染料释放剂更具优势。
• Monoaminophenazine leuco dyes and photothermographic materials containing same
  申请人：MINNESOTA MINING AND MANUFACTURING COMPANY

  公开号：EP0671393A1

  公开（公告）日：1995-09-13

  Photothermographic elements incorporating leuco forms of phenazinium dyes to provide a developed colour image. The dye has a nucleaus of the general formula: in which;    X represents    Y is H or any substituent other than amino or amido,    R¹, R², R⁴ and R¹⁰ are independently selected from H, alkyl, aryl, alkylsulfonyl, arysulfonyl, alkylcarbonyl, arylcarbonyl, or    R¹ and R² together represent the necessary atoms to complete a cyclic structure or one or more of R¹, R² and R⁴ represent the necessary atoms to complete a cyclic structure fused to the nucleus having skeletal atoms selected from C, N, 0 and S, and    R¹¹ represents any group which will not prevent oxidative cleavage of the X-N bond,    with the proviso that when R¹ is C₂H₅    R² is not C₂H₄NHSO₂CH₃.

  光热成像元件采用苯并二氮杂染料的白态形式，以提供发展后的彩色图像。该染料具有一般式的核：其中; X代表; Y为H或任何不是氨基或酰胺基的取代基，R¹，R²，R⁴和R¹⁰独立地选自H，烷基，芳基，烷基磺酰基，芳基磺酰基，烷基羰基，芳基羰基，或R¹和R²一起代表必要的原子以完成环状结构，或者R¹，R²和R⁴中的一个或多个代表必要的原子以完成与骨架原子（选自C，N，0和S）融合的环状结构，R¹¹代表任何不会防止X-N键的氧化裂解的基团，但当R¹为C₂H₅时，R²不为C₂H₄NHSO₂CH₃。
• Solid-State NMR, X-Ray Diffraction, and Theoretical Studies of Neutral Mononuclear Molecular Bis(triphenylphosphine)silver(I) Mono-Carboxylate and -Nitrate Systems
  作者：Simon Grabowsky、Allan H. White、Peter C. Healy、Kim M. Lapere、Seik Weng Ng、Brian W. Skelton、Duncan A. Wild、Graham A. Bowmaker、John V. Hanna

  DOI：10.1071/ch19616

  日期：——

  these complexes contain P2AgO2 molecular cores with four-coordinate silver in which the carboxylate ligands are weakly bound to the silver atoms via the two oxygen atoms giving rise to unsymmetrical chelate units. Crystal structure determinations and solid-state NMR spectra have also been analysed for the mononuclear molecular silver(i) nitrate complex [(Ph3P)2Ag(O2NO)] (9α) and two polymorphs of its

  [[Ph 3 P）2 Ag（O 2 XY）]形式的中性单核分子银（i）羧酸盐配合物，O 2 XY = O 2 CCH 2 Ph，O 2 CCHPh 2，O 2 CC（CH 3）3，O- 2 CCH 2 C（CH 3）3，和O 2 CCF 3（化合物1 - 4和5β）已在固态使用单晶X射线结构测定已经研究了，1D 31P CPMAS NMR和2D 31 P– 31 P CPCOSY NMR测量，以及从头计算模型。结果表明，这些配合物包含具有四配位银的P 2 AgO 2分子核，其中羧酸根配体通过两个氧原子与银原子弱结合，从而形成不对称的螯合单元。还分析了单核分子硝酸银（i）硝酸银配合物[（Ph 3 P）2 Ag（O 2 NO）]（9α）及其甲苯单溶剂化物的两个多晶型物（11α， β）。在在9α中，两个PPh 3配体具有相同的手性，而在11α中，β是相反的。通过量子力学孤立分子计算表明，尽管实验