N-[4-chloro-2-tert-butyldimethylsilyloxy-3-(N",N"-dimethylaminosulfonyl)phenyl]-N'-(2-bromophenyl)carbodiimide | 364363-04-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-[4-chloro-2-tert-butyldimethylsilyloxy-3-(N",N"-dimethylaminosulfonyl)phenyl]-N'-(2-bromophenyl)carbodiimide
• 英文别名: N-[4-chloro-2-tert-butyldimethylsilyloxy-3-(N'',N''-dimethylaminosulfonyl)phenyl]-N'-(2-bromophenyl)carbodiimide；N-[4-Chloro-2-tert-butyldimethylsilyloxy-3-(N'',N''-dimethylaninosulfonyl)phenyl]-N'-(2-bromophenyl)carbodiimide
• CAS: 364363-04-2
• 化学式: C₂₁H₂₇BrClN₃O₃SSi
• 分子量: 544.972
• InChiKey: NOTMEPRBTMYNMH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.87
• 重原子数：
  31
• 可旋转键数：
  7
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  79.7
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  N-[4-chloro-2-tert-butyldimethylsilyloxy-3-(N",N"-dimethylaminosulfonyl)phenyl]-N'-(2-bromophenyl)carbodiimide 在 N,N-二异丙基乙胺 、 cesium fluoride 作用下， 以 甲醇 为溶剂， 生成 3-{[[(2-bromophenyl)amino](cyanoimino)methyl]amino}-6-chloro-2-hydroxy-N,N-dimethylbenzenesulfonamide
  参考文献：
  名称：

  N,N′-Diarylcyanoguanidines as antagonists of the CXCR2 and CXCR1 chemokine receptors

  摘要：

  A series of N-(2-hydroxy-3-sulfonamidobenzene)-N'-arylcyanoguanidines was prepared. In general, these compounds proved to be potent antagonists of CXCR2 while the selectivity versus CXCR1 ranged from non-selective to > 200-fold. (c) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2006.08.042
• 作为产物：
  描述：

  N-[4-chloro-2-tert-butyldimethylsilyloxy-3-(N",N"-dimethylaminosulfonyl)phenyl]-N'-(2-bromophenyl) thiourea 在 甲基磺酰氯 、 三乙胺 作用下， 生成 N-[4-chloro-2-tert-butyldimethylsilyloxy-3-(N",N"-dimethylaminosulfonyl)phenyl]-N'-(2-bromophenyl)carbodiimide
  参考文献：
  名称：

  N,N′-Diarylcyanoguanidines as antagonists of the CXCR2 and CXCR1 chemokine receptors

  摘要：

  A series of N-(2-hydroxy-3-sulfonamidobenzene)-N'-arylcyanoguanidines was prepared. In general, these compounds proved to be potent antagonists of CXCR2 while the selectivity versus CXCR1 ranged from non-selective to > 200-fold. (c) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2006.08.042

文献信息

• Il-8 receptor anatagonists
  申请人：——

  公开号：US20030216375A1

  公开（公告）日：2003-11-20

  This invention relates to novel compounds of Formula (I), and compositions thereof, useful in the treatment of disease states mediated by the chemokine, Interleukin-8 (IL-8).

  该发明涉及式(I)的新化合物及其组合物，用于治疗由趋化因子白细胞介素-8（IL-8）介导的疾病状态。
• IL-8 receptor antagonists
  申请人：SmithKline Beecham Corporation

  公开号：US06680317B2

  公开（公告）日：2004-01-20

  This invention relates to novel compounds of Formula (I), and compositions thereof, useful in the treatment of disease states mediated by the chemokine, Interleukin-8 (IL-8).

  本发明涉及一种新型化合物（I）及其组合物，其在治疗由趋化因子白细胞介素-8（IL-8）介导的疾病状态中有用。
• N,N′-Diarylcyanoguanidines as antagonists of the CXCR2 and CXCR1 chemokine receptors
  作者：Hong Nie、Katherine L. Widdowson、Michael R. Palovich、Wei Fu、John D. Elliott、Deborah L. Bryan、Miriam Burman、Dulcie B. Schmidt、James J. Foley、Henry M. Sarau、Jakob Busch-Petersen

  DOI：10.1016/j.bmcl.2006.08.042

  日期：2006.11

  A series of N-(2-hydroxy-3-sulfonamidobenzene)-N'-arylcyanoguanidines was prepared. In general, these compounds proved to be potent antagonists of CXCR2 while the selectivity versus CXCR1 ranged from non-selective to > 200-fold. (c) 2006 Elsevier Ltd. All rights reserved.