2,4,6-三氯间苯二酚 | 26378-73-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 中文名称: 2,4,6-三氯间苯二酚
• 英文名称: 2,4,6-trichlororesorcinol
• 英文别名: 2,4,6-trichlorobenzene-1,3-diol
• CAS: 26378-73-4
• 化学式: C₆H₃Cl₃O₂
• mdl: MFCD00179932
• 分子量: 213.448
• InChiKey: NHOATJNESSAPCQ-UHFFFAOYSA-N

物化性质

• 熔点：
  83 °C(Solv: water (7732-18-5))
• 沸点：
  265.9±35.0 °C(Predicted)
• 密度：
  1.747±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  11
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  40.5
• 氢给体数：
  2
• 氢受体数：
  2

安全信息

• 海关编码：
  2908199090
• 储存条件：
  2-8°C

反应信息

• 作为反应物：
  描述：

  2,4,6-三氯间苯二酚 在 氯胺 作用下， 以 乙醚 为溶剂， 生成 2,2,4,4,6-pentachloro-5-cyclohexen-1,3-dione
  参考文献：
  名称：

  Reactions of resorcinol and its chlorinated derivatives with monochloramine: Identification of intermediates and products

  摘要：

  AbstractAn investigation of the reaction of resorcinol (compound 1) and its chlorinated derivatives 4‐chlororesorcinol (compound 4), 4,6‐dichlororesorcinol (compound 5), and 2,4,6‐trichlororesorcinol (compound 2) with monochloramine (NH2Cl) in ether and aqueous solution (pH 7) is reported. NH2Cl reacted with compounds 1, 2, 4, and 5 to give the pentachloro intermediate, 2,2,4,4,6‐pentachloro‐5‐cyclohexen‐1,3‐dione (compound 3), which underwent ring opening with H2O and loss of CO2 in the presence of NH2Cl to produce the following: 1,1,3,5,5‐pentachloro‐3‐penten‐2‐one (compound 6), 1,1,1,3,5,5‐hexachloro‐3‐penten‐2‐one (compound 7), and 1,1,3,5,5,5‐hexachloro‐3‐penten‐2‐one (compound 8). Compound 6 reacted further with NH2Cl to give compounds 7 and 8; in the presence of NH2Cl, compound 7 rearranged to compound 8. Mechanisms for the preceding reactions are analyzed in detail. Another aspect of the investigation involved a determination of the amounts of chloroform, CHCl3, which is produced from compound 3 with NH2Cl (4%) and with NaOCl (50%). The low production of CHCl3 from compound 3 and NH2Cl is discussed in connection with the probable reactions of compounds 7 and 8 with NH2Cl and H2O.

  DOI：

  10.1002/etc.5620181104
• 作为产物：
  描述：

  5H-heptachloro-cyclohexane-1,3-dione 在 溶剂黄146 、 tin(ll) chloride 作用下， 生成 2,4,6-三氯间苯二酚
  参考文献：
  名称：

  v. d. Stelt et al., Recueil des Travaux Chimiques des Pays-Bas, 1954, vol. 73, p. 1022,1026

  摘要：

  DOI：

文献信息

• Process for the preparation of halogenated (meth)acrylic esters and poly (meth) arcylates obtained with said (meth)acrylic esters
  申请人：Akzo Nobel N.V.

  公开号：EP0824096A2

  公开（公告）日：1998-02-18

  The present invention is directed to a process for the preparation of (meth)acrylates of halogenated alcohols by direct esterification of said alcohols with (meth)acrylic acid (chloride) wherein at least 2,6-substituted pyridine derivative is used as a polymerization inhibitor at room temperature or lower. Suitable at least 2,6-substituted pyridine derivatives are 2,6-lutidine, 2,4,6-collidine or 2,6-di-tert.butyl-4-methyl pyridine. With the halogenated (meth)acrylate esters prepared with the process according to the invention, very pure homo- and copolymers can be prepared, resulting in polymers having a low optical loss of 0.1 dB/cm or lower at 1300 nm and lower than 0.4 dB/cm at 1550 nm.

  本发明涉及一种通过将卤代醇与（甲基）丙烯酸（氯化物）直接酯化来制备（甲基）丙烯酸酯的方法，其中至少使用一种2,6-取代吡啶衍生物作为聚合抑制剂，温度为室温或更低。适用的至少2,6-取代吡啶衍生物包括2,6-吡啶、2,4,6-考林或2,6-二叔丁基-4-甲基吡啶。 通过根据本发明的方法制备的卤代（甲基）丙烯酸酯，可以制备非常纯净的同聚物和共聚物，从而得到在1300纳米处光学损耗低至0.1 dB/cm或更低，在1550纳米处低于0.4 dB/cm的聚合物。
• MODIFIER FOR AROMATIC POLYESTER AND AROMATIC POLYESTER RESIN COMPOSITION COMPRISING THE SAME
  申请人：TABATA Masayoshi

  公开号：US20110224343A1

  公开（公告）日：2011-09-15

  The present invention provides a modifier for aromatic polyesters which enhances the melt fluidity of aromatic polyesters without a significant decrease in the heat resistance of the aromatic polyesters, and an aromatic polyester resin composition including the modifier for aromatic polyesters. The present invention relates to a modifier for aromatic polyesters comprising polyhydric phenol residues and residues of aromatic polycarboxylic acid, acid halide or acid anhydride thereof, and the modifier comprises a material having a structure composed of a first residue selected from the group consisting of divalent residues represented by Formula (I): —Ar—W 1 x —Ar— and by Formula (II): —Ar—, the first residues being bonded to two identical or different second residues selected from the group consisting of monovalent residues represented by Formula (III): and monovalent residues represented by Formula (IV): —O—C(O)—R 7 —.

  本发明提供了一种用于芳香族聚酯的改性剂，可以增强芳香族聚酯的熔融流动性，而不明显降低芳香族聚酯的耐热性，以及包括该改性剂的芳香族聚酯树脂组合物。本发明涉及一种用于芳香族聚酯的改性剂，包括多羟基酚残基和芳香族多羧酸、酸卤或其酸酐残基，该改性剂包括具有以下结构的材料：第一残基，选择自由式(I)所代表的二价残基：—Ar—W1x—Ar—和自由式(II)所代表的：—Ar—，第一残基与选择自由式(III)所代表的单价残基：和自由式(IV)所代表的单价残基：—O—C(O)—R7—的两个相同或不同的第二残基结合。
• MEDICAL ADHESIVE COMPOSITIONS
  申请人：Liu Hongbo

  公开号：US20110230561A1

  公开（公告）日：2011-09-22

  A medical adhesive composition comprising, based upon the total weight of the composition, from about 50 wt. % to about 99.9 wt. % of one or more α-cyanoacrylate monomers and from about 0.1 wt. % to about 5 wt. % of one or more non-steroidal anti-inflammatory drugs (NSAIDs). Suitable NSAIDs include ibuprofen and acetaminophen. The resulting compositions provide enhances fibroblast proliferation and reduced cytotoxicity compared to compositions that do not contain NSAID.

  一种医用粘合剂组合物，包括以组合物的总重量为基础，约50重量％至约99.9重量％的一种或多种α-氰基丙烯酸酯单体和约0.1重量％至约5重量％的一种或多种非甾体抗炎药（NSAIDs）。适用的NSAIDs包括布洛芬和对乙酰氨基酚。与不含NSAID的组合物相比，所得到的组合物提供了增强成纤维细胞增殖和减少细胞毒性的效果。
• Process for preparing composite membranes
  申请人：E.I. DU PONT DE NEMOURS AND COMPANY

  公开号：EP0319990A2

  公开（公告）日：1989-06-14

  A multistage process for preparing interfacially polymerized polyamide reverse osmosis membranes on a microporous support is disclosed. the process involves applying a solution containing from 1 to 10 wt % of an aromatic diamine having 1 or 2 aromatic rings and 2 to 3 amino groups in a first solvent to the microporous substrate. Then a solution of an aromatic or cyclophatic acyl chloride having 1 or 2 rings and 2.2 to 4 acyl chloride groups in a solvent immiscible with the first solvent is applied to the microporous substrate. Then a solution of different acyl chlorides is applied to the substrate. The acyl chlorides in this second solution can have 2 to 4 acyl chloride groups attached to an aliphatic group of 6 to 12 carbon atoms or an aromatic or cycloaliphatic group having 1 or 2 rings and containing 8 to 14 carbon atoms. Also suitable for the second treatment are bis chloroformates.

  本发明公开了一种在微孔衬底上制备界面聚合聚酰胺反渗透膜的多级工艺。该工艺包括在微孔衬底上涂抹在第一溶剂中含有 1 至 10 wt % 具有 1 或 2 个芳香环和 2 至 3 个氨基的芳香族二胺的溶液。然后将具有 1 或 2 个芳香环和 2.2 至 4 个酰基氯基团的芳香族或环芳香族酰基氯在与第一种溶剂不相溶的溶剂中的溶液涂在微孔基底上。然后将不同酰基氯的溶液涂抹在基底上。第二种溶液中的酰基氯可以有 2 至 4 个酰基氯基团，连接在 6 至 12 个碳原子的脂肪族基团或具有 1 或 2 个环且含有 8 至 14 个碳原子的芳香族或环脂肪族基团上。适用于第二种处理方法的还有双氯甲酸酯。
• Cyanoacrylate compositions containing anti-microbial agent
  申请人：Closure Medical Corporation

  公开号：EP1508601A1

  公开（公告）日：2005-02-23

  A monomeric adhesive composition includes a polymerizable monomer, such as a 1,1-disubstituted monomer such as a cyanoacrylate, and an antimicrobial agent, wherein the antimicrobial agent is a phenolic active compound. Examples of suitable phenolic active compounds include halogenated phenol compounds such as chlorinated phenol compounds (such as triclosan) and brominated phenol compounds.

  单体粘合剂组合物包括可聚合单体（如氰基丙烯酸酯等 1,1-二取代单体）和抗菌剂，其中抗菌剂为酚类活性化合物。合适的酚类活性化合物包括卤代苯酚化合物，如氯代苯酚化合物（如三氯生）和溴代苯酚化合物。