mansonone I | 107794-39-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: mansonone I
• 英文别名: 4-Hydroxy-4,8,12-trimethyl-2-oxatricyclo[7.3.1.05,13]trideca-1(12),5(13),6,8-tetraene-10,11-dione
• CAS: 107794-39-8
• 化学式: C₁₅H₁₄O₄
• 分子量: 258.274
• InChiKey: HUXMQAHWPMWHPJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  19
• 可旋转键数：
  0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  63.6
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  mansonone I 在 硫酸 作用下， 以 乙醇 为溶剂， 反应 0.5h， 以56%的产率得到3,6,9-三甲基萘并[1,8-bc]吡喃-7,8-二酮
  参考文献：
  名称：

  Best, Wayne M.; Wege, Dieter, Australian Journal of Chemistry, 1986, vol. 39, # 4, p. 647 - 666

  摘要：

  DOI：
• 作为产物：
  描述：

  2-(2,3-dibromo-4-methoxy-6-methylphenoxy)-1-(5-methylfuran-2-yl)ethanone ethylene acetal 在 silver(II) oxide 、 正丁基锂 、 高氯酸 、 diiron nonacarbonyl 、 硝酸 作用下， 以 四氢呋喃 、 1,4-二氧六环 、 乙醚 、 正己烷 、 二氯甲烷 、 苯 为溶剂， 反应 12.0h， 生成 mansonone I
  参考文献：
  名称：

  Best, Wayne M.; Wege, Dieter, Australian Journal of Chemistry, 1986, vol. 39, # 4, p. 647 - 666

  摘要：

  DOI：

文献信息

• [EN] ANTI-CANCER AGENT CONTAINING NAPHTHOQUINONE COMPOUND<br/>[FR] AGENT ANTICANCEREUX CONTENANT UN COMPOSE NAPHTOQUINONE
  申请人：KOLON INC

  公开号：WO2001051004A2

  公开（公告）日：2001-07-19

  The present invention provides an anti-cancer drug containing naphthoquinone compound, and more particularly, to an anti-cancer drug containing naphthoquinone compounds of formula (1) and formula (2). The anti-cancer drug of the present invention has low toxicity and excellent anti-cancer activity. In formula (1) R1 and R5 are same or different and are each selected from the group consisting of hydrogen; hydroxy; alkoxy having from 1 to 10 carbons; alkyl having from 1 to 10 carbons; ester having from 1 to 10 carbons; and alkene having from 1 to 10 carbons. In formula (2) R1 and R2 are same or different and are each selected from the group consisting of hydrogen; hydroxy; primary amine; secondary amine; tertiary amine; carboxylic acid; alkoxy having from 1 to 10 carbons; alkyl having from 1 to 10 carbons; ester having from 1 to 10 carbons; and alkene having from 1 to 10 carbons; and R3 et R5 are same or different and are each selected from the group consisting of hydrogen; hydroxy; alkoxy having from 1 to 10 carbons; alkyl having from 1 to 10 carbons; ester having from 1 to 10 carbons; and alkene having from 1 to 10 carbons.