[5-(4-nitrophenyl)-1,3,4-thiadiazol-2-yl]hydrazine | 91096-52-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: [5-(4-nitrophenyl)-1,3,4-thiadiazol-2-yl]hydrazine
• CAS: 91096-52-5
• 化学式: C₈H₇N₅O₂S
• 分子量: 237.242
• InChiKey: ANYFBTQOVAJQLE-UHFFFAOYSA-N

物化性质

• 沸点：
  429.7±47.0 °C(Predicted)
• 密度：
  1.75±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  16.0
• 可旋转键数：
  3.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  106.97
• 氢给体数：
  2.0
• 氢受体数：
  7.0

反应信息

• 作为反应物：
  描述：

  [5-(4-nitrophenyl)-1,3,4-thiadiazol-2-yl]hydrazine 在 硫酸 作用下， 以 甲醇 为溶剂， 生成 4-(4-Nitrophenyl)-5-thia-2,3,7,8,16-pentazatetracyclo[7.7.0.02,6.010,15]hexadeca-1(16),3,6,8,10,12,14-heptaene
  参考文献：
  名称：

  Tiwari, Shailendra; Tiwari, Nirupama; Agrawal, Taruna, Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 1995, vol. 34, # 11, p. 1010 - 1012

  摘要：

  DOI：
• 作为产物：
  描述：

  5-(4-nitrophenyl)-1,3,4-thiadiazole-2-thiol 在 hydrazine hydrate monohydrate 作用下， 生成 [5-(4-nitrophenyl)-1,3,4-thiadiazol-2-yl]hydrazine
  参考文献：
  名称：

  Synthesis and spectral characterization of Zn(II) microsphere series for antimicrobial application

  摘要：

  Microsphere series have been synthesized by reacting zinc(II) acetate dihydrate with Schiff bases derived from 2-hydrazino-5-[substituted phenyl]-1,3,4-thiadiazole/oxadiazole/triazole with salicylaldehyde. Elemental analysis suggests that the complexes have 1:2 and 1:1 stoichiometry of the type [Zn(L)(2)(H2O)(2)] and [Zn(L')(2)(H2O)(2)]; LH = Schiff bases derived from 2-hydrazino-5-[substituted phenyl]-1,3,4-thia/oxadiazole with salicylaldehyde; L'H-2 = Schiff bases derived from 3-(substituted phenyl)-4-amino-5-hydrazino-1,2,4-triazole and salicylaldehyde and were characterized by elemental analyses, IR, H-1 NMR and C-13 NMR spectral data. Scanning electron microscopy (SEM) showed that synthesized materials have microsphere like structure and there EDX analysis comparably matches with elemental analysis. For the antimicrobial application Schiff bases and their zinc(II) complexes were screened for four bacteria e.g. Bacillus subtilis, Pseudomonas aeruginosa, Salmonella typhi, Streptococcus pyogenes and four fungi e.g. Cyrtomium falcatum, Aspergillus niger, Fusarium oxysporium and Curvularia pallescence by the reported method. Schiff base and Zn(II) compounds showed significant antimicrobial activities. However, activities increase upon chelation. Thermal analysis (TGA) data of compound (10) showed its stability up to 300 degrees C. (C) 2014 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.molstruc.2014.06.009

文献信息

• Synthesis, spectral characterization and antimicrobial studies of nano-sized oxovanadium(IV) complexes with Schiff bases derived from 5-(phenyl/substituted phenyl)-2-hydrazino-1,3,4-thiadiazole and indoline-2,3-dione
  作者：M.K. Sahani、U. Yadava、O.P. Pandey、S.K. Sengupta

  DOI：10.1016/j.saa.2014.01.041

  日期：2014.5

  oxovanadium(IV) complexes with Schiff bases derived by the condensation of 5-(phenyl/substituted phenyl)-2-hydrazino-1,3,4-thiadiazoles and indoline-2,3-dione have been prepared in ethanol in the presence of sodium acetate. Micro-analytical data, magnetic susceptibility, UV–Vis, IR, EPR and XRD spectral techniques were used to confirm the structures. Electronic absorption spectra of the complexes suggest

  在乙醇中制备了一类新的与席夫碱形成的氧杂钒（IV）配合物，该席夫碱是由5-（苯基/取代的苯基）-2-肼基-1,3,4-噻二唑与二氢吲哚-2,3-二酮缩合得到的。在乙酸钠存在下。微观分析数据，磁化率，UV-Vis，IR，EPR和XRD光谱技术用于确认结构。配合物的电子吸收光谱表明为方形-金字塔形几何形状。氧钒（IV）配合物具有单斜晶系，并且发现粒径为18.0 nm至24.0 nm（纳米尺寸）。测定了合成化合物对黑曲霉真菌，炭疽菌和炭疽菌腐烂的体外抗真菌活性。和体外抗菌活性通过筛选针对革兰氏阴性化合物（确定大肠杆菌和伤寒沙门氏菌）和革兰氏阳性（金黄色葡萄球菌和枯草芽孢杆菌）的细菌菌株。氧钒（IV）配合物比游离配体具有更高的抗菌作用。
• Shams El-Dine Sh.; Jawad; Mahmoud, Pharmazie, 1984, vol. 39, # 2, p. 101 - 103
  作者：Shams El-Dine Sh.、Jawad、Mahmoud

  DOI：——

  日期：——
• Synthesis, spectral and antimicrobial activity of Zn(II) complexes with Schiff bases derived from 2-hydrazino-5-[substituted phenyl]-1,3,4-thiadiazole and benzaldehyde/2-hydroxyacetophenone/indoline-2,3-dione
  作者：Ajay K. Singh、O.P. Pandey、S.K. Sengupta

  DOI：10.1016/j.saa.2013.04.045

  日期：2013.9

  Zn(II) complexes have been synthesized by reacting zinc acetate with Schiff bases derived from 2-hydrazino-5-[substituted phenyl]-1,3,4-thiadiazole and 2-hydroxyacetophenone/benzaldehyde/indoline-2, 3-dione. All these complexes are soluble in DMF and DMSO; low molar conductance values indicate that they are non electrolytes. Elemental analyses suggest that the complexes have 1:2 metal to ligands stoichiometry of the types [ZnL2(H2O)(2)](L = monoanionic Schiff bases derived from 2-hydrazino-5-[substituted phenyl]-1,3,4-thiadiazole and 2-hydroxyacetophenone/indoline-2,3-dione) [ZnL2'(OOCCH3)(2)(H2O)(2)] (L' = neutral Schiff bases derived from 2-hydrazino-5-[substituted phenyl]-1,3,4-thiadiazole and benzaldehyde), and they were characterized by IR, H-1 NMR, and C-13 NMR. Particle sizes of synthesized compounds were measured with dynamic light scattering (DLS) analyser which indicates that particle diameter are of the range ca. 100-200 nm. All these Schiff bases and their complexes have also been screened for their antibacterial (Bacillus subtilis (B. subtilis), Escherichia colt (E. coli) and antifungal activities (Colletotrichum falcatum (C. falcatum), Aspergillus niger (A. niger), Fusarium oxysporium (F. oxysporium) Curvularia pallescence (C pallescence). The antimicrobial activities have shown that upon complexation the activity increases. (C) 2013 Elsevier B.V. All rights reserved.