1-(4,5-dimethoxy-2-nitrobenzyl)-6,7-dimethoxyisoquinoline | 25944-25-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 异喹啉及其衍生物
• 英文名称: 1-(4,5-dimethoxy-2-nitrobenzyl)-6,7-dimethoxyisoquinoline
• 英文别名: 6'-nitropapaverine；1-(4,5-dimethoxy-2-nitro-benzyl)-6,7-dimethoxy-isoquinoline；1-(4,5-Dimethoxy-2-nitro-benzyl)-6,7-dimethoxy-isochinolin；1-(p-methoxy-O-nitrobenzyl)-6,7-dimethoxyisoquinoline；1-(3,4-Dimethoxy-6-nitrobenzyl)-6,7-dimethoxy-isochinolin; 6'-Nitro-papaverin；1-(3,4-Dimethoxy-6-nitro-benzyl)-6,7-dimethoxy-isochinolin；1-[(4,5-Dimethoxy-2-nitrophenyl)methyl]-6,7-dimethoxyisoquinoline
• CAS: 25944-25-6
• 化学式: C₂₀H₂₀N₂O₆
• mdl: MFCD00206116
• 分子量: 384.389
• InChiKey: LDDJQOUHXBDHKJ-UHFFFAOYSA-N

物化性质

• 熔点：
  178-179 °C
• 沸点：
  557.8±45.0 °C(Predicted)
• 密度：
  1.264±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  28
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  95.6
• 氢给体数：
  0
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  1-(4,5-dimethoxy-2-nitrobenzyl)-6,7-dimethoxyisoquinoline 在 碘 、 sodium acetate 作用下， 以 丙醇 为溶剂， 反应 0.33h， 以36.4%的产率得到azaberbinone N-oxide
  参考文献：
  名称：

  A Novel Rearragement of a Papaverine Derivative into Isoquino[1,2-b]quinozoline Derivative

  摘要：

  DOI：

  10.3987/r-1987-07-1841
• 作为产物：
  描述：

  罂粟碱 在 硝酸 作用下， 生成 1-(4,5-dimethoxy-2-nitrobenzyl)-6,7-dimethoxyisoquinoline
  参考文献：
  名称：

  Hesse, Justus Liebigs Annalen der Chemie, 1872, vol. Suppl.8, p. 288

  摘要：

  DOI：

文献信息

• Pschorr; Staehlin; Silberbach, Chemische Berichte, 1904, vol. 37, p. 1932
  作者：Pschorr、Staehlin、Silberbach

  DOI：——

  日期：——
• Physiological responses to prolonged aquatic hypoxia in the Queensland lungfish Neoceratodus forsteri
  作者：Peter K Kind、Gordon C Grigg、David T Booth

  DOI：10.1016/s1569-9048(02)00113-1

  日期：2002.8

  The effects of moderate and severe hypoxia on air breathing frequency and respiratory properties of the blood of the Queensland (Australian) lungfish Neoceratodus forsteri were measured in fish exposed to these conditions for 14-22 days at 20 degreesC. Haemoglobin oxygen affinity increased after exposure to moderate hypoxia (Pw(O2) = 60 mmHg), but did not increase further after exposure to severe hypoxia (Pwo(2) = 40 mmHg). The P-50 of whole blood (20 degreesC, Pco(2) = 16.0 mmHg) fell from 22.0 +/- 1.5 mmHg in normoxic conditions to 19.0 +/- 1.0 mmHg in hypoxic conditions. Under both moderate and severe hypoxia, haematocrit, haemoglobin, blood lactate, and erythrocyte phosphate concentrations did not differ from normoxic values. The observed increase in haemoglobin oxygen affinity in response to aquatic hypoxia is typical of compensatory responses seen in obligate water breathers, but smaller. This suggests that the capacity of lungfish to respond to hypoxia by breathing air removes the necessity for further left-shifting of the oxygen equilibrium curve. (C) 2002 Elsevier Science B.V. All rights reserved.
• AHMAD, YUSUF;BEGUM, TAHIRA;QURESHI, IZHAR HUSSAIN;RAHMAN, ATTA-UR;ZAMAN, +, HETEROCYCLES, 26,(1987) N 7, 1841-1852
  作者：AHMAD, YUSUF、BEGUM, TAHIRA、QURESHI, IZHAR HUSSAIN、RAHMAN, ATTA-UR、ZAMAN, +

  DOI：——

  日期：——
• IVANOV CH., XIM.-FARMATSEVT. ZH., 1977, 11, HO 2, 32-36
  作者：IVANOV CH.

  DOI：——

  日期：——
• Hesse, Justus Liebigs Annalen der Chemie, 1872, vol. Suppl.8, p. 288
  作者：Hesse

  DOI：——

  日期：——