The structure of dehydro-oogoniol (3 beta,11 alpha,15 beta,29-tetrahydroxystigmasta-5,24(28)(E)-dien-7-one), a female-activating hormone of the water mold Achlya, has been confirmed by synthesis. The starting material was progesterone, which was converted to the 11 alpha, 15 beta-dihydroxy derivative by microbiological hydroxylation with Aspergillus giganteus (ATCC 10059). The side chain was constructed
脱氢-oogoniol(3 beta,11 alpha,15 beta,29-tetrahydroxystigmasta-5,24(28)(E)-dien-7-one)的结构是
水模Achlya的一种女性激活激素。综合确认。起始原料是
孕酮,它通过用巨大的曲霉(A
TCC 10059)进行微
生物羟基化反应而转化为11α,15β-二羟基衍
生物。通过维蒂希和霍纳-埃蒙斯反应以逐步的方式构建侧链,然后通过烯丙基氧化引入C-7酮。合成化合物的
生物活性与天然激素相同。