变色酸 | 148-25-4

• 物质功能分类: 化学试剂 - 有机试剂 - 芳烃
• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 中文名称: 变色酸
• 中文别名: 1,8-二羟基萘-3,6-二磺酸；铬变酸
• 英文名称: chromatotropic acid
• 英文别名: 1,8-dihydroxynaphthalene-3,6-disulphonic acid；4,5-dihydroxynaphthalene-2,7-disulphonic acid；4,5-dihydroxynaphthalene-2,7-disulfonic acid；chromotropic acid；4,5-Dihydroxynapthalene-2,7-disulfonic acid；4,5-dihydroxy-naphthalene-2,7-disulfonic acid；4,5-Dioxonionaphthalene-2,7-disulfonate
• CAS: 148-25-4
• 化学式: C₁₀H₈O₈S₂
• mdl: MFCD00003968
• 分子量: 320.301
• InChiKey: HLVXFWDLRHCZEI-UHFFFAOYSA-N

物化性质

• 沸点：
  429.2°C (rough estimate)
• 密度：
  1.7929 (rough estimate)

计算性质

• 辛醇/水分配系数(LogP)：
  0.5
• 重原子数：
  20
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  166
• 氢给体数：
  4
• 氢受体数：
  8

安全信息

• 海关编码：
  2908999090
• 危险品标志：
  Xn
• WGK Germany：
  3
• RTECS号：
  TE6130000
• 危险类别：
  6.1
• 安全说明：
  S22,S24/25
• 危险类别码：
  R22
• 包装等级：
  III
• 危险品运输编号：
  UN3288
• 危险性防范说明：
  P260,P264,P280,P301+P330+P331,P303+P361+P353,P304+P340,P305+P351+P338,P310,P321,P363,P405,P501
• 危险性描述：
  H314
• 储存条件：
  室温

SDS

---

Section 1. IDENTIFICATION OF THE SUBSTANCE/MIXTURE
Product identifiers
Product name : 4,5-Dihydroxynaphthalene-2,7-disulphonic acid
CAS-No. : 148-25-4
Relevant identified uses of the substance or mixture and uses advised against
Identified uses : Laboratory chemicals, Manufacture of substances

---

Section 2. HAZARDS IDENTIFICATION
Classification of the substance or mixture
Classification according to Regulation (EC) No 1272/2008 [EU-GHS/CLP]
Skin irritation (Category 2)
Eye irritation (Category 2)
Specific target organ toxicity - single exposure (Category 3)
Classification according to EU Directives 67/548/EEC or 1999/45/EC
Irritating to eyes, respiratory system and skin.
Label elements
Labelling according Regulation (EC) No 1272/2008 [CLP]
Pictogram
Signal word Warning
Hazard statement(s)
H315 Causes skin irritation.
H319 Causes serious eye irritation.
H335 May cause respiratory irritation.
Precautionary statement(s)
P261 Avoid breathing dust/ fume/ gas/ mist/ vapours/ spray.
P305 + P351 + P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove
contact lenses, if present and easy to do. Continue rinsing.
Supplemental Hazard none
Statements
According to European Directive 67/548/EEC as amended.
Hazard symbol(s)
R-phrase(s)
R36/37/38 Irritating to eyes, respiratory system and skin.
S-phrase(s)
S26 In case of contact with eyes, rinse immediately with plenty of water and
seek medical advice.
S37/39 Wear suitable gloves and eye/face protection.
Other hazards - none

---

Section 3. COMPOSITION/INFORMATION ON INGREDIENTS
Substances
Formula : C10H8O8S2
Molecular Weight : 320,3 g/mol
Component Concentration
4,5-Dihydroxynaphthalene-2,7-disulphonic acid
CAS-No. 148-25-4 -
EC-No. 205-712-7

---

Section 4. FIRST AID MEASURES
Description of first aid measures
General advice
Consult a physician. Show this safety data sheet to the doctor in attendance.
If inhaled
If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician.
In case of skin contact
Wash off with soap and plenty of water. Consult a physician.
In case of eye contact
Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician.
If swallowed
Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.
Most important symptoms and effects, both acute and delayed
To the best of our knowledge, the chemical, physical, and toxicological properties have not been
thoroughly investigated.
Indication of any immediate medical attention and special treatment needed
no data available

---

Section 5. FIREFIGHTING MEASURES
Extinguishing media
Suitable extinguishing media
Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.
Special hazards arising from the substance or mixture
Carbon oxides, Sulphur oxides
Advice for firefighters
Wear self contained breathing apparatus for fire fighting if necessary.
Further information
no data available

---

Section 6. ACCIDENTAL RELEASE MEASURES
Personal precautions, protective equipment and emergency procedures
Use personal protective equipment. Avoid dust formation. Avoid breathing vapors, mist or gas. Ensure
adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust.
Environmental precautions
Do not let product enter drains.
Methods and materials for containment and cleaning up
Pick up and arrange disposal without creating dust. Sweep up and shovel. Keep in suitable, closed
containers for disposal.
Reference to other sections
For disposal see section 13.

---

Section 7. HANDLING AND STORAGE
Precautions for safe handling
Avoid contact with skin and eyes. Avoid formation of dust and aerosols.
Provide appropriate exhaust ventilation at places where dust is formed.Normal measures for preventive fire
protection.
Conditions for safe storage, including any incompatibilities
Store in cool place. Keep container tightly closed in a dry and well-ventilated place.
Specific end uses
no data available

---

Section 8. EXPOSURE CONTROLS/PERSONAL PROTECTION
Control parameters
Components with workplace control parameters
Exposure controls
Appropriate engineering controls
Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and
at the end of workday.
Personal protective equipment
Eye/face protection
Safety glasses with side-shields conforming to EN166 Use equipment for eye protection tested
and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).
Skin protection
Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique
(without touching glove's outer surface) to avoid skin contact with this product. Dispose of
contaminated gloves after use in accordance with applicable laws and good laboratory practices.
Wash and dry hands.
The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and
the standard EN 374 derived from it.
Body Protection
impervious clothing, The type of protective equipment must be selected according to the
concentration and amount of the dangerous substance at the specific workplace.
Respiratory protection
For nuisance exposures use type P95 (US) or type P1 (EU EN 143) particle respirator.For higher
level protection use type OV/AG/P99 (US) or type ABEK-P2 (EU EN 143) respirator cartridges.
Use respirators and components tested and approved under appropriate government standards
such as NIOSH (US) or CEN (EU).

---

Section 9. PHYSICAL AND CHEMICAL PROPERTIES
Information on basic physical and chemical properties
a) Appearance Form: solid
b) Odour no data available
c) Odour Threshold no data available
d) pH no data available
e) Melting point/freezing no data available
point
f) Initial boiling point and no data available
boiling range
g) Flash point no data available
h) Evaporation rate no data available
i) Flammability (solid, gas) no data available
j) Upper/lower no data available
flammability or
explosive limits
k) Vapour pressure no data available
l) Vapour density no data available
m) Relative density no data available
n) Water solubility no data available
o) Partition coefficient: n- no data available
octanol/water
p) Autoignition no data available
temperature
q) Decomposition no data available
temperature
r) Viscosity no data available
s) Explosive properties no data available
t) Oxidizing properties no data available
Other safety information
no data available

---

Section 10. STABILITY AND REACTIVITY
Reactivity
no data available
Chemical stability
no data available
Possibility of hazardous reactions
no data available
Conditions to avoid
no data available
Incompatible materials
Strong oxidizing agents
Hazardous decomposition products
Other decomposition products - no data available

---

Section 11. TOXICOLOGICAL INFORMATION
Information on toxicological effects
Acute toxicity
no data available
Skin corrosion/irritation
no data available
Serious eye damage/eye irritation
no data available
Respiratory or skin sensitization
no data available
Germ cell mutagenicity
no data available
Carcinogenicity
IARC: No component of this product present at levels greater than or equal to 0.1% is identified as
probable, possible or confirmed human carcinogen by IARC.
Reproductive toxicity
no data available
Specific target organ toxicity - single exposure
Inhalation - May cause respiratory irritation.
Specific target organ toxicity - repeated exposure
no data available
Aspiration hazard
no data available
Potential health effects
Inhalation May be harmful if inhaled. Causes respiratory tract irritation.
Ingestion May be harmful if swallowed.
Skin May be harmful if absorbed through skin. Causes skin irritation.
Eyes Causes serious eye irritation.
Signs and Symptoms of Exposure
To the best of our knowledge, the chemical, physical, and toxicological properties have not been
thoroughly investigated.
Additional Information
RTECS: Not available

---

Section 12. ECOLOGICAL INFORMATION
Toxicity
no data available
Persistence and degradability
no data available
Bioaccumulative potential
no data available
Mobility in soil
no data available
Results of PBT and vPvB assessment
no data available
Other adverse effects
no data available

---

Section 13. DISPOSAL CONSIDERATIONS
Waste treatment methods
Product
Offer surplus and non-recyclable solutions to a licensed disposal company. Contact a licensed
professional waste disposal service to dispose of this material. Dissolve or mix the material with a
combustible solvent and burn in a chemical incinerator equipped with an afterburner and scrubber.
Contaminated packaging
Dispose of as unused product.

---

Section 14. TRANSPORT INFORMATION
UN number
ADR/RID: - IMDG: - IATA: -
UN proper shipping name
ADR/RID: Not dangerous goods
IMDG: Not dangerous goods
IATA: Not dangerous goods
Transport hazard class(es)
ADR/RID: - IMDG: - IATA: -
Packaging group
ADR/RID: - IMDG: - IATA: -
Environmental hazards
ADR/RID: no IMDG Marine pollutant: no IATA: no
Special precautions for user
no data available

---

Section 15. REGULATORY INFORMATION
This safety datasheet complies with the requirements of Regulation (EC) No. 1907/2006.
Safety, health and environmental regulations/legislation specific for the substance or mixture
no data available
Chemical Safety Assessment
no data available

---

Section 16. OTHER INFORMATION
Further information
Copyright 2012 Co. LLC. License granted to make unlimited paper copies for internal use
only.
The above information is believed to be correct but does not purport to be all inclusive and shall be
used only as a guide. The information in this document is based on the present state of our knowledge
and is applicable to the product with regard to appropriate safety precautions. It does not represent any
guarantee of the properties of the product. Corporation and its Affiliates shall not be held
liable for any damage resulting from handling or from contact with the above product. See
and/or the reverse side of invoice or packing slip for additional terms and conditions of sale.

制备方法与用途

理化性质

变色酸的学名为“1,8-二羟基萘-3,6-二磺酸”，分子式C₁₀H₈O₈S₂，分子量320.29。它是一种白色针状晶体（含二分子结晶水），溶于水中，并能与三氯化铁溶液反应呈现绿色。

变色酸的一钠盐和二钠盐均为白色或结晶性粉末，极易溶解于水，而不溶于食盐水。三钠盐的水溶液呈中性，而四钠盐的水溶液则呈碱性。它由β-萘磺酸经磺化、硝化、还原、碱熔及酸化制得，用于制造偶氮染料和蒽醌染料，并用作试剂。

变色酸反应及应用

变色酸反应是一种用于检查次甲二氧基的化学反应。当化合物中的次甲二氧基被酸水解生成甲醛后，与变色酸缩合形成紫至粉红色产物。同样地，也可以使用没食子酸代替变色酸来检测次甲二氧基。

伪劣玉米蛋白粉的识别方法

1. 检查样品在变色酸中的颜色变化情况。
2. 将0.1～0.2g样品置于干燥的50mL烧杯中，加入约1mL变色酸（1g/L浓硫酸溶液），小心加热至产生微烟。然后加入10mL水。若溶液变为紫色，则表明样品中含有蛋白精，属伪劣产品。
3. 采用显微镜检查法：将样品放大10～20倍，在体视镜下观察。若发现黄色易碎的微粒，小心取出数粒放入50mL烧杯中，加入约0.5mL变色酸。加热至产生微烟后，慢慢加入10～15mL水。如果溶液变为紫色，则样品中含有蛋白精，属于伪劣产品。

这些有关变色酸反应及应用的信息由Chemicalbook的晓楠编辑整理。

化学性质

变色酸是固体结晶，易溶于水。

用途

该品是染料酸性媒介深蓝的中间体。用于羊毛织物染色。它是通过4-氯邻氨基苯酚重氮化后与变色酸偶合制得的。此外，变色酸也用于制造偶氮染料和蒽醌染料，并用作试剂。

用途

该品可用来测定铬、钛及甲醛；检定铬、汞、银、钛、氯酸盐、甲醛、硝酸盐和亚硝酸盐；作为偶氮染料的中间体。

生产方法

由T酸（1-氨基萘-3,6,8-三磺酸铵盐）转变成钠盐，再经碱熔制得。工业上用其钠盐作染料中间体时，外观为浅灰色或灰色膏状物，变色酸含量不低于50%。纯品的钠盐含2分子结晶水（CAS号：[5808-22-0]），为白色针状或叶状结晶，易溶于水，熔点大于300℃。变色酸也可由4-氯-5-羟基-2,7-萘二磺酸为原料制得。

反应信息

• 作为反应物：
  描述：

  变色酸 在 盐酸 、 sodium carbonate 、 tin(ll) chloride 作用下， 生成 3-氨基-4,5-二羟基萘-2,7-二磺酸
  参考文献：
  名称：

  Hantower; Taeuber, Chemische Berichte, 1898, vol. 31, p. 2158

  摘要：

  DOI：
• 作为产物：
  描述：

  1-氨基-8-萘酚-3,6-二磺酸 在 硫酸 作用下， 生成 变色酸
  参考文献：
  名称：

  Woroshzow; Jurygina, 1933, vol. 3, p. 453,455

  摘要：

  DOI：

文献信息

• Carbonyl J Derivatives: A New Class of HIV-1 Integrase Inhibitors
  作者：Karl Maurer、Ann H. Tang、George L. Kenyon、Andrew D. Leavitt

  DOI：10.1006/bioo.2000.1166

  日期：2000.6

  to treat HIV-1 infection. As such, new classes of integrase inhibitors are needed. We have combined molecular modeling and combinatorial chemistry to identify and develop a new class of HIV-1 integrase inhibitors, the Carbonyl J [N,N'-bis(2-(5-hydroxy-7-naphthalenesulfonic acid)urea] derivatives. This new class includes a number of compounds with sub-micromolar IC(50) values for inhibiting purified

  病毒复制和致病性需要整合HIV-1基因组的DNA拷贝，而这种高度特异性的分子过程是由病毒编码的整合酶介导的。整合的需要，加上哺乳动物细胞缺乏已知的类似过程，使得整合成为HIV-1复制的治疗性抑制剂的诱人靶标。尽管有许多关于HIV-1 IN抑制剂的报道，但尚未出现用于治疗HIV-1感染的此类化合物。因此，需要新型的整合酶抑制剂。我们已经结合分子建模和组合化学来识别和开发新型的HIV-1整合酶抑制剂，即羰基J [N，N'-双（2-（5-羟基-7-萘磺酸）脲]衍生物。这类新化合物包括许多具有亚微摩尔IC（50）值的化合物，可在体外抑制纯化的HIV-1整合酶。在本文中，我们描述了对于羰基J衍生物内的整合酶抑制和细胞毒性很重要的化学特征。版权所有2000学术出版社。
• [EN] COMPOSITIONS AND INKS CONTAINING DISAZO DYES<br/>[FR] COMPOSITIONS ET ENCRES CONTENANT DES DISAZOIQUES
  申请人：AVECIA LTD

  公开号：WO2003104332A1

  公开（公告）日：2003-12-18

  A process for printing an image on a substrate comprising applying thereto a composition comprising a liquid medium and a compound of Formula (1) A-N=N-L-N=N-A wherein: each A independently is optionally substituted aryl or heteroaryl; and L is an optionally substituted, optionally metallised 1,8-dihydroxynaphthylene group; provided that: (i) at most one of the groups represented by A has a hydroxy substituent ortho to the -N=N- groups shown in Formula (1); and (ii) Formula (1) is not: Also claimed are compositions for printing, compounds and processes for making the compounds.

  一种在基材上印刷图像的过程，包括向其施加一种包含液体介质和公式(1)化合物的组成物：A-N=N-L-N=N-A，其中：每个A独立的是可选取代的芳基或杂芳基；L是1,8-二羟基萘基团，可选地被取代，可选地金属化；前提是：(i)在由A表示的组中，最多只有一个组在公式(1)所示的-N=N-基团邻位具有羟基取代基；且(ii)公式(1)不是：还要求保护印刷用组成物、化合物以及制造化合物的过程。
• [EN] DIALLYLDISULPHIDE COMPOUNDS HAVING ANTILIPIDEMIC AND ANTIOXIDANT ACTIVITY<br/>[FR] COMPOSES DE DIALLYLDISULFURE PRESENTANT UNE ACTIVITE ANTILIPIDEMIQUE ET ANTIOXYDANTE
  申请人：DEPT OF SCIENCE AND TECHNOLOGY

  公开号：WO2004039771A1

  公开（公告）日：2004-05-13

  The present invention relates to a novel diallyldisulphide derivative having formula I as shown herebelow and their pharmaceutically acceptable salts; R-CH = CH - CH2-S-S-CH2-CH = CH-R (Formula I)wherein R=C6HnXp[when n = 3 to 5, p = 2 to 0; X=H, Cl, Br, F, CF3, CH3, CN, COOH, NO2, NH2, OH, OCmH2m+1(m = 1 to 8)]

  本发明涉及一种新型二烯丙基二硫化物衍生物，其具有下文所示的化学式I及其药学上可接受的盐；R-CH = CH - CH2-S-S-CH2-CH = CH-R（化学式I）其中R=C6HnXp[当n = 3至5，p = 2至0；X=H，Cl，Br，F，CF3，CH3，CN，COOH，NO2，NH2，OH，OCmH2m+1（m = 1至8）]
• Studies of Collectors. VII. Flotation of Heavy Metal Ions by Using Colored Surfactant
  作者：Yoshifumi Koide、Shigekazu Sato、Kimiho Yamada

  DOI：10.1246/bcsj.59.715

  日期：1986.3

  Colored surfactants containing complex radicals(R-Bc, R-Bs, R-Sh, R-S, R-C, R-Ha, and R-Hb) were applied as ion-flotation collectors and foam-fractionation collectors. The extent of floatabilities for the colored complexing surfactants and metal ions was easily recognized by the degree of discoloration. R-Bc, R-Bs, and R-Sh with low HLB values formed floatable complexes in pH 6–9 with Cu2+, Cd2+, Hg2+

  含有复合自由基的有色表面活性剂（R-Bc、R-Bs、R-Sh、RS、RC、R-Ha和R-Hb）被用作离子浮选捕收剂和泡沫分馏捕收剂。通过变色程度很容易识别有色络合表面活性剂和金属离子的漂浮程度。具有低 HLB 值的 R-Bc、R-Bs 和 R-Sh 在 pH 6-9 中与 Cu2+、Cd2+、Hg2+、Pb2+ 和 Sr2+ 形成可漂浮的复合物。R-Sh、R-Bc 和 R-Bs 的残留浓度低于 0.1 ppm；然而，在获得最低金属离子浓度后，这些浓度逐渐增加。由于 RC、R-Ha 和 R-Hb 具有高 HLB 值，因此它们很容易通过泡沫分馏使 Cu2+、Pb2+ 和 Cd2+ 漂浮。泡沫或水溶液中 RC、R-Ha 和 R-Hb 的浓度与其发泡能力相关。
• IMAGING CONTRAST AGENTS USING NANOPARTICLES
  申请人：Zheng Shiying

  公开号：US20080095699A1

  公开（公告）日：2008-04-24

  The present invention relates to a nanoparticle comprising self-assembled crosslinked, amphiphilic block copolymers and at least one immobilized dye, wherein the self-assembled, crosslinked, amphiphilic block copolymers comprise a hydrophilic block and a hydrophobic block, wherein the self-assembled, crosslinked, amphiphilic block copolymers are self-assembled to form a core of the nanoparticle comprising a hydrophobic block, wherein the hydrophobic block is derived from at least one pendant multifunctional crosslinked alkoxy silane or amino silane moiety, and an exterior of the nanoparticle comprising a hydrophilic block, and wherein the immobilized dye is immobilized in the core.

  本发明涉及一种纳米颗粒，包括自组装交联的两性块共聚物和至少一种固定的染料，其中自组装交联的两性块共聚物包括一个亲水性块和一个疏水性块，其中自组装交联的两性块共聚物自组装形成纳米颗粒的核心，包括一个疏水性块，其中疏水性块源自至少一种挂链多功能交联的烷氧基硅烷或氨基硅烷基团，以及纳米颗粒的外部包括一个亲水性块，固定的染料固定在核心中。