N-(allylcarbamothioyl)benzamide | 139461-38-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-(allylcarbamothioyl)benzamide
• 英文别名: N-allyl-N'-benzoylthiourea；1-allyl-3-benzoylthiourea；N-(prop-2-enylcarbamothioyl)benzamide
• CAS: 139461-38-4
• 化学式: C₁₁H₁₂N₂OS
• mdl: MFCD02653733
• 分子量: 220.295
• InChiKey: FXSMGTPJMTTXAH-UHFFFAOYSA-N

物化性质

• 密度：
  1.170±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  15
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.09
• 拓扑面积：
  73.2
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  N-(allylcarbamothioyl)benzamide 在 肼 作用下， 反应 0.17h， 以97%的产率得到烯丙基硫脲
  参考文献：
  名称：

  一种方便高效的合成单和N，N-二取代的硫脲的方法

  摘要：

  开发了一种方便的方法，该方法在无溶剂条件下通过水合肼将N-取代的和N，N-二取代的-N'-苯甲酰基硫脲进行苯甲酰化来合成单和N，N-二取代的硫脲。混合N-取代的-N'-苯甲酰基硫脲和水合肼，并在室温下在无溶剂的情况下搅拌，以高收率得到相应的N-取代的硫脲。

  DOI：

  10.1016/j.tetlet.2005.06.135
• 作为产物：
  描述：

  苯甲酰氯 以 丙酮 为溶剂， 反应 0.5h， 生成 N-(allylcarbamothioyl)benzamide
  参考文献：
  名称：

  Straightforward Approach Toward Dihydrothiazoles via Intramolecular Bromocyclization

  摘要：

  An intramolecular bromonium ion-assisted cyclization with sulfur as an internal nucleophile is described. Starting from benzoyl chlorides, this method provides an easy procedure for the synthesis of dihydrothiazole derivatives in moderate to good yields.

  DOI：

  10.1080/00397911.2015.1067707

文献信息

• IMINE COMPOUND
  申请人：TAISHO PHARMACEUTICAL CO., LTD

  公开号：EP1820504A1

  公开（公告）日：2007-08-22

  An imine compound represented by the formula: wherein A represents a heterocyclic group; R1, R2, an R3 each represent a hydrogen atom, a halogen atom, a C1-10 alkyl group optionally substituted with an aryl group(s) substituted with a halogen atom (s), a C3-10 cycloalkyl group, a C1-6 haloalkyl group, a C1-10 alkoxy group, etc.; R4 represents an optionally substituted C1-10 alkyl, C2-6 alkenyl, or aryl group; R5 represents a hydrogen atom, a C1-10 alkoxy group, a C1-6 haloalkyl group, an optionally substituted C1-10 alkyl or C2-6 alkenyl group, an optionally substituted aryl or heterocyclic group, etc.; W represents -CO-, -CO-CO-, -CO-NH-, -CS-NH-, or -SO2-, or a cannabinoid-receptor agonist comprising said imine compound as an active ingredient. The imine compound of the present invention has a cannabinoid-receptor agonist effect, and is useful as a therapeutic or prophylactic drug for pains and autoimmune diseases.

  本发明的亚胺化合物的化学式为：其中A代表杂环基团；R1、R2和R3分别代表氢原子、卤原子、一个C1-10烷基基团，该基团可以选择性地被芳基基团取代，该芳基基团被卤原子取代，一个C3-10环烷基基团，一个C1-6卤代烷基基团，一个C1-10烷氧基基团等；R4代表一个可以选择性取代的C1-10烷基、C2-6烯基或芳基基团；R5代表一个氢原子、一个C1-10烷氧基基团、一个C1-6卤代烷基基团、一个可以选择性取代的C1-10烷基或C2-6烯基基团、一个可以选择性取代的芳基或杂环基团等；W代表-CO-、-CO-CO-、-CO-NH-、-CS-NH-或-SO2-，或者一种包含上述亚胺化合物作为活性成分的大麻素受体激动剂。本发明的亚胺化合物具有大麻素受体激动剂效应，并且可用作治疗或预防疼痛和自身免疫疾病的药物。
• COMPOSITIONS AND METHODS FOR SELECTIVE SEPARATION OF MINERALS FROM SULFIDE ORES
  申请人：Cytec Industries Inc.

  公开号：US20180099293A1

  公开（公告）日：2018-04-12

  Compositions including blends of one or more acrylamide/allyl thiourea polymer as a first depressant, and one or more carboxyalkyl dithiocarbamate compound as a second depressant, and their use as depressants in the beneficiation of sulfide minerals from ores and/or concentrates are disclosed herein, along with methods for selectively separating value sulfide minerals from non-value sulfide minerals in a froth flotation process for the recovery of such value minerals.

  本文披露了包括一种或多种丙烯酰胺/烯丙基硫脲聚合物作为第一抑制剂，以及一种或多种羧基二硫代氨基甲酸酯化合物作为第二抑制剂的混合物，以及它们作为抑制剂在从矿石和/或浓缩物中选矿硫化矿物的过程中的使用，还披露了用于在沫浮选过程中从非价值硫化矿物中选择性地分离有价值硫化矿物的方法。
• Imine Compound
  申请人：Saito Shiuji

  公开号：US20080312435A1

  公开（公告）日：2008-12-18

  An imine compound represented by the formula: wherein A represents a heterocyclic group; R 1 , R 2 , an R 3 each represent a hydrogen atom, a halogen atom, a C 1-10 alkyl group optionally substituted with an aryl group(s) substituted with a halogen atom(s), a C 3-10 cycloalkyl group, a C 1-6 haloalkyl group, a C 1-10 alkoxy group, etc.; R 4 represents an optionally substituted C 1-10 alkyl, C 2-6 alkenyl, or aryl group; R 5 represents a hydrogen atom, a C 1-10 alkoxy group, a C 1-6 haloalkyl group, an optionally substituted C 1-10 alkyl or C 2-6 alkenyl group, an optionally substituted aryl or heterocyclic group, etc.; W represents —CO—, —CO—CO—, —CO—NH—, —CS—NH—, or —SO 2 —, or a cannabinoid-receptor agonist comprising said imine compound as an active ingredient. The imine compound of the present invention has a cannabinoid-receptor agonist effect, and is useful as a therapeutic or prophylactic drug for pains and autoimmune diseases.

  一种以以下式表示的亚胺化合物：其中A代表杂环基团；R1、R2和R3分别表示氢原子、卤素原子、C1-10烷基，该烷基可选地取代有芳基，所述芳基取代有卤素原子，C3-10环烷基，C1-6卤代烷基，C1-10烷氧基等；R4表示可选地取代的C1-10烷基，C2-6烯基或芳基；R5表示氢原子，C1-10烷氧基，C1-6卤代烷基，可选地取代的C1-10烷基或C2-6烯基，可选地取代的芳基或杂环基团等；W表示—CO—，—CO—CO—，—CO—NH—，—CS—NH—或—SO2—，或以该亚胺化合物为活性成分的大麻素受体激动剂。本发明的亚胺化合物具有大麻素受体激动剂作用，可用作治疗或预防疼痛和自身免疫性疾病的药物。
• Copolymers of acrylamide with allylthioureas as sulfide mineral depressants
  申请人：AMERICAN CYANAMID COMPANY

  公开号：EP0338276A2

  公开（公告）日：1989-10-25

  Various acrylamide/allyl thiourea polymers and their use as depressants in the beneficiation of sulfide minerals from ores are disclosed.

  公开了各种丙烯酰胺/烯丙基硫脲聚合物及其在从矿石中选取硫化矿物时作为抑制剂的用途。
• Compositions and methods for selective separation of minerals from sulfide ores
  申请人：Cytec Industries Inc.

  公开号：US10369577B2

  公开（公告）日：2019-08-06

  Compositions including blends of one or more acrylamide/allyl thiourea polymer as a first depressant, and one or more carboxyalkyl dithiocarbamate compound as a second depressant, and their use as depressants in the beneficiation of sulfide minerals from ores and/or concentrates are disclosed herein, along with methods for selectively separating value sulfide minerals from non-value sulfide minerals in a froth flotation process for the recovery of such value minerals.

  本文公开了包括作为第一抑制剂的一种或多种丙烯酰胺/烯丙基硫脲聚合物和作为第二抑制剂的一种或多种羧基烷基二硫代氨基甲酸酯化合物的混合物的组合物，以及它们在从矿石和/或精矿中选矿硫化矿物时作为抑制剂的用途，同时还公开了在泡沫浮选工艺中选择性地从无价值硫化矿物中分离出有价值硫化矿物以回收此类有价值矿物的方法。