(R)-quinuclidin-3-yl 6-((3S,4R)-4-amino-3-methoxypiperidin-1-yl)hexanoate | 860169-83-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 奎宁环
• 英文名称: (R)-quinuclidin-3-yl 6-((3S,4R)-4-amino-3-methoxypiperidin-1-yl)hexanoate
• 英文别名: [(3R)-1-azabicyclo[2.2.2]octan-3-yl] 6-[(3S,4R)-4-amino-3-methoxypiperidin-1-yl]hexanoate
• CAS: 860169-83-1
• 化学式: C₁₉H₃₅N₃O₃
• 分子量: 353.505
• InChiKey: RLFVFTCMGPYXAW-SQNIBIBYSA-N

物化性质

• 沸点：
  453.8±45.0 °C(Predicted)
• 密度：
  1.12±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  25
• 可旋转键数：
  9
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.95
• 拓扑面积：
  68
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  (R)-quinuclidin-3-yl 6-((3S,4R)-4-amino-3-methoxypiperidin-1-yl)hexanoate 在 三甲基乙酰氯 、 三乙胺 作用下， 以 四氢呋喃 为溶剂， 反应 1.0h， 生成 Naronapride
  参考文献：
  名称：

  WO2007/28073

  摘要：

  公开号：
• 作为产物：
  描述：

  (R)-1-benzyl-3-((6-((3S,4R)-4-(dibenzylamino)-3-methoxypiperidin-1-yl)hexanoyl)oxy)quinuclidin-1-ium bromide 在 palladium over charcoal 甲酸铵 作用下， 以 甲醇 为溶剂， 反应 10.0h， 生成 (R)-quinuclidin-3-yl 6-((3S,4R)-4-amino-3-methoxypiperidin-1-yl)hexanoate
  参考文献：
  名称：

  WO2007/149929

  摘要：

  公开号：

文献信息

• [EN] STEREOISOMERIC COMPOUNDS AND METHODS FOR THE TREATMENT OF GASTROINTESTINAL AND CENTRAL NERVOUS SYSTEM DISORDERS<br/>[FR] COMPOSES STEREO-ISOMERES ET METHODES DE TRAITEMENT DE TROUBLES GASTRO-INTESTINAUX ET DU SYSTEME NERVEUX CENTRAL
  申请人：ARYX THERAPEUTICS

  公开号：WO2005068461A1

  公开（公告）日：2005-07-28

  The subject invention provides stereoisomeric compounds of formula (X): wherein the variables are as defined herein, and compositions for the safe and effective treatment of various gastrointestinal disorders including, but not limited to, gastroparesis, gastroesophageal reflux and related conditions. The compounds of the subject invention are also useful in treating a variety of conditions involving the central nervous system.

  本发明提供了式（X）的立体异构化合物：其中变量如本文所定义，并提供了用于安全有效治疗各种胃肠道疾病的组合物，包括但不限于胃轻瘫、胃食管反流及相关症状。本发明的化合物还可用于治疗涉及中枢神经系统的各种疾病。
• Stereoisomeric compounds and methods for the treatment of gastrointestinal and central nervous system disorders
  申请人：Irwin Ian

  公开号：US20050197363A1

  公开（公告）日：2005-09-08

  The subject invention provides stereoisomeric compounds of formula (X): wherein the variables are as defined herein, and compositions for the safe and effective treatment of various gastrointestinal disorders including, but not limited to, gastroparesis, gastroesophageal reflux and related conditions. The compounds of the subject invention are also useful in treating a variety of conditions involving the central nervous system.

  本发明提供了式（X）的立体异构化合物，其中变量如此处所定义，并提供用于安全有效治疗各种胃肠道疾病的组合物，包括但不限于胃轻瘫，胃食管反流和相关疾病。本发明的化合物还可用于治疗涉及中枢神经系统的各种疾病。
• Synthetic Methods and Intermediates for Stereoisomeric Compounds Useful for the Treatment of Gastrointestinal and Central Nervous System Disorders
  申请人：By Kolbot

  公开号：US20070078265A1

  公开（公告）日：2007-04-05

  The subject invention provides methods and/or processes for making stereoisomeric compounds of formula (X): wherein the variables are as defined herein, and compositions for the safe and effective treatment of various gastrointestinal disorders including, but not limited to, gastroparesis, gastroesophageal reflux and related conditions. The compounds of the subject invention are also useful in treating a variety of conditions involving the central nervous system.

  本发明提供了制备式（X）立体异构化合物的方法和/或过程，其中变量如本文所定义，并提供用于安全有效治疗各种胃肠道疾病的组合物，包括但不限于胃轻瘫，胃食管反流和相关疾病。本发明的化合物还可用于治疗涉及中枢神经系统的各种疾病。
• COMPOUNDS AND METHODS FOR THE TREATMENT OF GASTROINTESTINAL AND CENTRAL NERVOUS SYSTEM DISORDERS
  申请人：Becker Cyrus

  公开号：US20080085915A1

  公开（公告）日：2008-04-10

  The subject invention provides stereoisomeric compounds of formula (X): wherein the variables are as defined herein, and compositions for the safe and effective treatment of various gastrointestinal disorders including, but not limited to, gastroparesis, gastroesophageal reflux and related conditions. The compounds of the subject invention are also useful in treating a variety of conditions involving the central nervous system.

  本发明提供了化学式（X）的立体异构化合物，其中变量如此处所定义，并提供了用于安全有效治疗各种胃肠道疾病的组合物，包括但不限于胃轻瘫、胃食管反流和相关疾病。本发明的化合物还可用于治疗涉及中枢神经系统的各种疾病。
• Stereoisomeric Compounds And Methods For The Treatment Of Gastrointestinal And Central Nervous System Disorders
  申请人：Irwin Ian

  公开号：US20080085921A1

  公开（公告）日：2008-04-10

  The subject invention provides stereoisomeric compounds of formula (X): wherein the variables are as defined herein, and compositions for the safe and effective treatment of various gastrointestinal disorders including, but not limited to, gastroparesis, gastroesophageal reflux and related conditions. The compounds of the subject invention are also useful in treating a variety of conditions involving the central nervous system.

  本发明提供了式（X）的立体异构化合物： 其中变量如本文所定义，并提供了用于治疗各种胃肠道疾病的安全有效的组合物，包括但不限于胃轻瘫，胃食管反流和相关疾病。本发明的化合物还可用于治疗涉及中枢神经系统的各种疾病。