(5S)-6-(5-氯-2-吡啶基)-7-氧代-6,7-二氢-5H-吡咯并[3,4-b]吡嗪-5-基4-甲基-1-哌嗪羧酸酯4-氧化物 | 151851-70-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯并吡嗪类
• 中文名称: (5S)-6-(5-氯-2-吡啶基)-7-氧代-6,7-二氢-5H-吡咯并[3,4-b]吡嗪-5-基4-甲基-1-哌嗪羧酸酯4-氧化物
• 中文别名: 佐匹克隆-N-氧化物
• 英文名称: Eszopiclone N-Oxide
• 英文别名: [(7S)-6-(5-chloropyridin-2-yl)-5-oxo-7H-pyrrolo[3,4-b]pyrazin-7-yl] 4-methyl-4-oxidopiperazin-4-ium-1-carboxylate
• CAS: 151851-70-6
• 化学式: C₁₇H₁₇ClN₆O₄
• 分子量: 404.813
• InChiKey: IPTIKKTXLHVRKN-INIZCTEOSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.1
• 重原子数：
  28
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.35
• 拓扑面积：
  107
• 氢给体数：
  0
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  右佐匹克隆 在 potassium permanganate 、 sodium hydroxide 作用下， 生成 (5S)-6-(5-氯-2-吡啶基)-7-氧代-6,7-二氢-5H-吡咯并[3,4-b]吡嗪-5-基4-甲基-1-哌嗪羧酸酯4-氧化物
  参考文献：
  名称：

  SPECTROPHOTOMETRIC DETERMINATION OF ESZOPICLONE IN PURE AND PHARMACEUTICAL FORMS

  摘要：

  Six spectrophotometric methods for determination of eszopiclone have been developed, validated and applied for the assay of the drug in pharmaceuticals. Methods A, B, C and D are based on ion pair complexation of drug, in acidic buffers, with triphenylmethane dyes viz., Bromothymol blue(BTB), Bromophenol blue(BPB), Bromocresol green(BCG) and Bromocresol purple(BCP). The complexes are extracted into chloroform and absorbance is measured around at 415 nm as function of concentration of the drug. The stoichiometry of the complex is found 1:1 in each case. Method E depends upon charge transfer complexation of neutralized drug with iodine which produces iodide ion whose absorbance at 366 nm is measured as function of concentration of the drug. This complex, too, has 1:1 composition as determined by Job's method. Method F is developed on the basis of oxidation of the drug with alkaline KMnO4 which generates green colored manganate ion with I-max 610 nm. As the intensity of green color increased with increasing time kinetics of the reaction is followed and calibration curves are constructed by using initial rate and fixed time methods. Excellent recovery studies with high accuracy and precession indicate that the methods can be successfully used in industries for the assay of drug in pure form and pharmaceuticals.

  DOI：

  10.4067/s0717-97072012000400025